Global and African Perspectives on Lung Cancer

Integrating Infections, Genomics, and the Exposome

AvZodwa Dlamini

Inbunden, Engelska, 2026

Del i serien Integrative Cancer Biology and Health Equity

1 866 kr

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Beskrivning

This book provides a comprehensive and integrated view of lung cancer, combining global evidence with African-specific perspectives. It examines the epidemiology, histological subtypes, and multifactorial causes of the disease, with in-depth coverage of genomic alterations, molecular signatures, and population-specific variations in Africa. The chapters explore the combined impact of environmental exposures, tobacco smoke, air pollution, asbestos, silica, radon, and indoor pollutants and infectious agents, including viruses, bacteria, and parasites, as drivers of lung carcinogenesis. The volume also addresses the role of the exposome, chronic infections, immune modulation, and the lung microbiome in shaping disease risk, treatment response, and survival outcomes. The book also presents the advances in molecular diagnostics, biomarker discovery, precision oncology, and AI-enabled healthcare innovations alongside the influence of social determinants such as poverty, education, cultural factors, and healthcare access. With a focus on prevention, early detection, and equitable access to care, the book highlights African-led research, public health policies, and system-level solutions to reduce disparities and improve outcomes.Key Features: Offers a comprehensive integration of global evidence with African-specific perspectives on lung cancerExplores epidemiology, histological subtypes, and multifactorial causes, including environmental and infectious driversHighlights genomic alterations, molecular signatures, and population-specific variations relevant to AfricaExamines the role of the exposome, chronic infections, immune modulation, and lung microbiome in carcinogenesis and outcomesProvides evidence-based recommendations for prevention, policy, and health system strengtheningThis book is intended for researchers, clinicians, policymakers, and students in cancer research, molecular biology, epidemiology, public health, and related biomedical and health sciences fields, globally, with particular relevance for those engaged in advancing lung cancer research and care in Africa and other resource-constrained settings.

Produktinformation

Utgivningsdatum:2026-11-10
Mått:210 x 280 x undefined mm
Format:Inbunden
Språk:Engelska
Serie:Integrative Cancer Biology and Health Equity
Antal sidor:288
Förlag:Taylor & Francis Ltd
ISBN:9781041217459

Utforska kategorier

Epidemiologi och medicinsk statistik inom Medicin
Biologi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

Mer om författaren

Zodwa Dlamini is a Professor of Molecular Oncology at the University of Pretoria with a strong track record in advancing cancer research, prevention, and care across Africa and globally. She is the Founding Director of the Pan African Cancer Research Institute (PACRI), Director of the SAMRC Precision Oncology Research Unit (PORU), and holder of the DSTI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP). She is a recipient of the 2024 South African Women in Science Award (SAWiSA) for Distinguished Woman Researcher and was awarded the prestigious Oppenheimer Memorial Trust Sabbatical Grant in 2026 to advance research on the exposome and cancer. She also serves as a Co-Investigator on the Cancer Grand Challenges initiative addressing global cancer inequities. Professor Dlamini is Founding President and Executive Board Member of the African Academy of Integrated Morphology and Health Sciences (AAIMHS), providing strategic leadership and institutional direction. She contributes to global science initiatives through the Global Alliance for Genomics and Health (GA4GH) and the Global Exposome Forum (GEF), and in 2025 chaired a high-level African exposomics consultation shaping continental strategy. She holds visiting professorships in the UK and USA, advancing global dialogue on precision health, exposomics, and cancer equity.

Innehållsförteckning

Chapter 1: Understanding the Global and African Landscape of Lung Cancer: Epidemiology, Histological Subtypes, and Multifactorial Etiologies. Chapter 2: Genomic Alterations and Molecular Signatures in Lung Cancer: From Somatic Mutations to Population-Specific Insights in Africa. Chapter 3: The Role of the Exposome in Lung Cancer Risk: Integrating Lifetime Environmental and Lifestyle Exposures with Genomic Susceptibility. Chapter 4: Transdisciplinary Framework for Lung Cancer Research: Integrating Infections, Genomics, and the Exposome in African and Global Contexts. Chapter 5: Infectious Agents as Drivers of Lung Cancer: Viral, Bacterial, and Parasitic Contributions to Carcinogenesis in Global and African Contexts. Chapter 6: Tobacco Smoke and Air Pollution as Core Environmental Drivers of Lung Cancer: Mechanisms, Global Burden, and African-Specific Challenges. Chapter 7: Occupational and Residential Exposures to Carcinogens: Assessing Risks from Asbestos, Silica, Radon, and Indoor Pollutants in Lung Cancer Development. Chapter 8: Chronic Infections, Immune Modulation, and the Lung Microbiome: How Pathogens Influence Lung Cancer Risk and Therapy Outcomes. Chapter 9: The Social Determinants of Health in Lung Cancer: Linking Poverty, Education, Cultural Beliefs, and Healthcare Access to Risk and Outcomes. Chapter 10: Innovations in Molecular Diagnostics and Biomarker Discovery: Transforming Lung Cancer Detection, Prognosis, and Personalized Care. Chapter 11: Precision Oncology in Lung Cancer: Advances in Targeted Therapies, Immunotherapies, and Overcoming Barriers in African Settings. Chapter 12: Artificial Intelligence and Big Data Applications in Lung Cancer: Enhancing Screening, Diagnosis, and Treatment through Digital Innovation. Chapter 13: Integrating Environmental and Infectious Exposure Data into Clinical Decisions-Making Comprehensive Lung Cancer Care. Chapter 14: Patient Experiences, Psychosocial Challenges, and Quality of Life Considerations in Lung Cancer Management. Chapter 15: Comprehensive Lung Cancer Prevention Strategies: Public Health Policies, Community Engagement, and Evidence-Based Interventions. Chapter 16: Strengthening Health Systems to Improve Lung Cancer Screening, Diagnosis, and Treatment: Addressing Access Gaps and Disparities. Chapter 17: Future Directions in Lung Cancer Research and Care: Integrating Multi-Level Determinants and Promoting African-Led Innovation.