This contributed volume, the first in a set of two, explores the intricate relationship between trace elements, heavy metals, sustainability, and global health. It presents a detailed analysis of the occurrence, distribution, and impact of trace elements and heavy metals in both the natural environment and human health. It underscores how these elements, while essential in trace amounts, can become toxic at higher concentrations, contributing to pollution, bioaccumulation in ecosystems, and posing significant risks to human and animal health. The purpose of this book is to provide an integrated understanding of how trace elements and heavy metals intersect with the goals of sustainability and public health, offering a comprehensive resource for researchers, policymakers, and practitioners in environmental science, toxicology, public health, and sustainability fields. It highlights how these pollutants can hinder efforts to achieve global health and sustainability targets, such as the United Nations' Sustainable Development Goals (SDGs), particularly those focused on clean water, health, and sustainable production and consumption.