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Focus Second Edition is an even richer version of the best-selling English language learning series for upper secondary students.

 

Through its proven 3Ms methodology (Motivation, Memory, and Meaning), cutting-edge digital solutions and high-quality educational videos from the BBC, the course offers everything students and teachers have requested.

 

Find out more at english.com/focus

This book covers challenges and solutions in establishing Industry 4.0 standards for Internet of Things. It proposes a clear view about the role of Internet of Things in establishing standards. The sensor design for industrial problem, challenges faced, and solutions are all addressed. The concept of digital twin and complexity in data analytics for predictive maintenance and fault prediction is also covered. The book is aimed at existing problems faced by the industry at present, with the goal of cost-efficiency and unmanned automation. It also concentrates on predictive maintenance and predictive failures. In addition, it includes design challenges and a survey of literature.

This book covers challenges and solutions in establishing Industry 4.0 standards for Internet of Things. It proposes a clear view about the role of Internet of Things in establishing standards. The sensor design for industrial problem, challenges faced, and solutions are all addressed. The concept of digital twin and complexity in data analytics for predictive maintenance and fault prediction is also covered. The book is aimed at existing problems faced by the industry at present, with the goal of cost-efficiency and unmanned automation. It also concentrates on predictive maintenance and predictive failures. In addition, it includes design challenges and a survey of literature.

Take an exhilarating ride through Jaguar production history, from the original SS to the I-PACE EV, with narratives, photos, and spec tables for each.In 1935, a pair of motorcycle enthusiasts in Coventry, England—William Lyons and William Walmsley—established a firm called the Swallow Sidecar Company. Soon, they pivoted to automobiles, launching a sporting saloon (i.e., sedan) called the Jaguar SS. The decision set in motion the company that would create Britain’s most beloved line of high-performance automobiles.The Complete Book of Jaguar, 2nd Edition, tells the whole story with:A thorough profile for every production model, presented in chronological orderSpec tables highlighting key technical and performance specifications and their changes across each modelNarratives by distinguished motoring historian Nigel Thorley discussing the innovations and technology featured in each modelColor photography of new and restored examplesHistorical black-and-white imageryA new chapter covering Jaguar’s commitment to an alt-fuel future with extensive up-to-date coverage of the hybrid E-PACE and F-PACE SUVs and the I-PACE EVAs you turn the pages, follow Jaguar’s trajectory to becoming one of the world’s most celebrated automakers. In England’s bleak postwar years, the company was a shining star—first with its XK120, followed by the XK140 and XK150. Sporting sedans like the Mark 2 and Mark X set the bar for luxury four-door transport in the ’50s and ’60s. Then Jaguar stunned the world in 1961 with the achingly beautiful E-Type, a genuine 150 mph sports car. Though Jaguar lost its way periodically in the modern era, it has bounded back stronger than ever in the twenty-first century with a strong lineup that includes the new F-Type sports car. The Complete Book of Jaguar, 2nd Edition, is the essential and most current guide to one of the truly iconic marques in the history of sports and luxury automobiles.Filled with photos and data-packed spec charts, Motorbooks’ Complete Book series presents automotive and motorcycle enthusiasts with authoritative histories celebrating their favorite vehicles. Some other subjects in the series include Corvette, Porsche 911, Ford Mustang, Ducati, BMW Motorcycles, Dodge and Plymouth Muscle Cars, and Volkswagen GTI.  Also available from the series:The Complete Book of Ford Mustang, The Complete Book of BMW Motorcycles, The Complete Book of Corvette, The Complete Book of Porsche 911, The Complete Book of Dodge and Plymouth Muscle Cars, The Complete Book of Chevrolet Camaro, The Complete Book of Classic Ford Tractors, The Complete Book of Classic John Deere Tractors, and The Complete Book of Classic Volkswagens.

This new edition explores BMW's M3 and M4, including the development history and their race and rally successes worldwide, supported by full and detailed specifications for each generation. It expands on the previous edition to bring the story right up to the present day, with details of all models produced up to the end of 2025.Developed in the 1980s, the BMW M3 was intended to be the world’s most successful racing saloon car. Not only did it achieve that in its very first season of motorsport, but went on to achieve lasting commercial success as a high-performance road car.The first M4 cars were launched in 2014. Although they shared the same chassis/platform and all their running gear with the new M3 Saloon, the new cars had completely fresh two-door bodyshells, with even more high-tech solutions. This highly desirable sportier model, in both coupé and convertible forms, along with model variants and special editions are explored in detail.Fully illustrated throughout, with a lavish array of colour photographs and magnificently detailed cutaway drawings of mechanical equipment, this comprehensive and authoritative book is a must for all BMW M3 and M4 enthusiasts.Originally penned by Graham Robson, this new edition was updated by fellow historian Brian Long, and includes all the recent models, developments and motorsport action.

This book is Volume 2 of the EUROCK 2018 proceedings. Geomechanics and Geodynamics of Rock Masses contains contributions presented at EUROCK 2018, the 2018 International Symposium of the International Society for Rock Mechanics (ISRM 2018, Saint Petersburg, Russia, 22-26 May 2018). Dedicated to recent advances and achievements in the fields of geomechanics and geotechnology, the main topics of the book include:- Physical and mechanical properties of fractured rock (laboratory testing and rock properties, field measurements and site investigations)- Geophysics in rock mechanics- Rock mass strength and failure- Nonlinear problems in rock mechanics- Effect of joint water on the behavior of rock foundation- Numerical modeling and back analysis- Mineral resources development: methods and rock mechanics problems- Rock mechanics and underground construction in mining, hydropower industry and civil engineering- Rock mechanics in petroleum engineering- Geodynamics and monitoring of rock mass behavior- Risks and hazards- Geomechanics of technogenic depositsGeomechanics and Geodynamics of Rock Masses will be of interest to researchers and professionals involved in the various branches of rock mechanics and rock engineering. EUROCK 2018, organized by the Saint Petersburg Mining University, is a continuation of the successful series of ISRM symposia in Europe, which began in 1992 in Chester, UK.

The International Committee on Large Dams (ICOLD) held its 26th International Congress in Vienna, Austria (1-7 July 2018). The proceedings of the congress focus on four main questions: 1. Reservoir sedimentation and sustainable development; 2. Safety and risk analysis; 3. Geology and dams, and 4. Small dams and levees. The book thoroughly discusses these questions and is indispensable for academics, engineers and professionals involved or interested in engineering, hydraulic engineering and related disciplines.

Enter into the world of reading with My Very First I Can Read! This comprehensive emergent reading program addresses all the components of reading mastery based on the latest early literacy research. Written by educator and reading specialist Dr. Julie M. Wood, with lively illustrations by Sebastien Braun, this Common Core-aligned program stars Tug the Pup and an endearing group of characters who will lead beginners through the proven steps for successful reading. The Learn to Read with Tug the Pup program features important Common Core State Standards connections, including sight word vocabulary, simple text, strong picture support, and character and plot development. The eleven short stories in box set three are Guided Reading Levels E-G, which means the vocabulary, sentence structure, and plots are still simple, but richer than box sets one and two. Each box set also comes with reward stickers and a Parents' Guide that provides hours of additional reading activities.

Cellular Internet of Things: From Massive Deployments to Critical 5G Applications, Second Edition, gives insights into the recent and rapid work performed by the 3rd Generation Partnership Project (3GPP) and the Multefire Alliance (MFA) to develop systems for the Cellular IoT. Beyond the technologies, readers will learn what the mMTC and cMTC market segments look like, deployment options and expected performance in terms of system capacity, expected battery lifetime, data throughput, access delay time and device cost, regulations for operation in unlicensed frequency bands, and how they impact system design and performance.

This new edition contains updated content on the latest EC-GSM IoT, LTE-M and NB-IoT features in 3GPP Release 15, critical communication, i.e. URLLC, specified in 3GPP Release 15 for both LTE and NR, LTE-M and NB-IoT for unlicensed frequency bands specified in the Multefire Alliance (MFA), and an updated outlook of what the future holds in Industrial IoT and drone communications, amongst other topics.

Provides ubiquitous wireless connectivity for a diverse range of services and applications, describing their performance and how their specifications were developed to meet the most demanding requirements Describes licensed and unlicensed technologies based on 2G, 4G and 5G technologies and how they have evolved towards the Cellular IoT Presents the Narrowband Internet of Things technology and how GSM, LTE and NR have been designed to provide Cellular Internet of Things services Provides use cases that cover ultra-low complex systems connecting billions of devices (massive MTC, mMTC), critical MTC and cMTC based on Ultra-Reliable and Low Latency Communications (URLLC) to meet strict latency and reliability requirements

Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd�Edition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject's fascinating appeal.

The content of this new edition has been completely updated to include current information on all aspects of basic and clinical immunology. The superbly drawn figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide interesting insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Moreover, as part of the Academic Cell line of textbooks, Primer to The Immune Response, 2nd Edition contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections.

Complete yet concise coverage of the basic and clinical principles of immunology Engaging conversational writing style that is to the point and very readable Over 200 clear, elegant color illustrations Comprehensive glossary and list of abbreviations

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists.

This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries.

Contains the history of major breakthroughs in immunology featured with authenticity and insider details Gives an insight into personal aspects of the players in the history of immunology Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author

Laboratory Methods in Enzymology: Protein Part B brings together a number of core protocols concentrating on protein, carefully written and edited by experts. Indispensable tool for the researcher Carefully written and edited by experts to contain step-by-step protocols In this volume we have brought together a number of core protocols concentrating on protein

Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants.

In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful.

Provides contributions from leading international authorities in the field Features immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune system Lists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines

The upcoming 5G specifications from 3GPP, to be available in 2018, will include LTE-Advanced Pro as well as a new 5G radio-access technology. This practical and very successful book, written by engineers working closely with 3GPP, gives insight into the newest technologies and standards adopted by 3GPP, with detailed explanations of the specific solutions chosen and their implementation in LTE, LTE-Advanced, and LTE-Advanced Pro, as well as providing a detailed description of the path to 5G and the associated underlying technologies.

This edition has been thoroughly revised and updated to reflect the large extensions to LTE as introduced in 3GPP Releases 12 and 13 and the role of LTE in the upcoming 5G era. New to this edition includes updated content on:

4G and 5G Radio Access Spectrum for 4G and 5G Machine-Type Communication Device-to-Device Communication License-assisted Access Full-dimension MIMO Small-cell enhancements, eIMTA, FDD+TDD aggregation, dual connectivity Requirements on and general structure of 5G wireless access, addressing the existing and new usage scenarios for 5G Technical solutions for the new 5G radio-access technology

The authors of this book all work at Ericsson Research and have been deeply involved in 3G and 4G development and standardization. They are leading experts in the field and are today actively contributing to the standardization of 4G and 5G within 3GPP.

The leading book on 3GPP specifications for LTE, LTE-Advanced, and LTE-Advanced Pro covering up to and including Release 13, written by Ericsson engineers who are heavily involved in the development of 3GPP specifications Ten new chapters and coverage of all major features introduced with Release 12 and 13 Two completely new chapters on 5G wireless access including a detailed description of the key technology components under development by 3GPP

Rare and Interesting Cases in Pulmonary Medicine provides a look into the uncommon diseases encountered in the field of pulmonary medicine. Using a case-based approach, the book provides clinical scenarios that include relevant accompanying radiology and pathology. Also included are frequently asked questions for each area, as well as a diagnosis and summary, presenting the reader with the most high yield information on each topic.

Appropriate for medical students, residents, fellows, and physicians interested in pulmonary medicine, the case-based approach to each topic allows accessibility to the uncommon diseases of the field while also highlighting high yield and important points.

Provides case-based approaches to the uncommon diseases of pulmonary medicine, including supporting radiology and pathology Includes uncommon case studies, providing relevant references for further reading and research opportunities Presents related topics with accompanying clinical pearls for direct application in the field

Electronics Explained, Second Edition, takes a systems based approach to the fundamentals of electronics, covering the different types of electronic circuits, how they work, and how they fit together to create modern electronic equipment, enabling you to apply, use, select, operate and discuss common electronic products and systems.

This new edition has been updated to show the latest technological trends with added coverage of:

Internet of Things (IoT) Machine-to-Machine (M2M) technology Ethernet to 100 Gb/s Wi-Fi, Bluetooth and other wireless technologies 5G New Radio cellular standards Microcontrollers and programming with the Arduino, BASIC Stamp and others Learn about the basic components of electronics such as resistors, capacitors, inductors, transformers, diodes, transistors, and integrated circuits Discover different types of circuits, using the functional block diagram approach which makes it easy to understand their purpose and application Get involved with Hands-On projects in each chapter, using components and ICs with the breadboarding socket

The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

5G NR: The Next Generation Wireless Access Technology, Second Edition, follows the authors' highly celebrated books on 3G and 4G and provides a new level of insight into 5G NR. After background discussion of 5G, including requirements, spectrum aspects, and the standardization timeline, all technology features of the first phase of NR are described in detail. The book covers the NR physical-layer structure and higher-layer protocols, RF and spectrum aspects, and co-existence and interworking with LTE. The book provides a good foundation in NR and different NR technology components, giving insight into why a certain solution has been selected.This second edition is updated to reflect the latest developments in Release 16 and includes brand new chapters on: NR in unlicensed spectrum; NR-U in Rel-16; IAB; V2X and sidelink in Rel-16; industrial IoT; IIoT and referring to the URLLC enhancements for PDCCH; RIM/CL; and positioning. Also included are the key radio-related requirements of NR; design principles; technical features of basic NR transmission structure-showing where it was inherited from LTE, where it deviates from it, and the reasons why- NR multi-antenna transmission functionality; detailed description of the signals and functionality of the initial NR access, including signals for synchronization and system information; random access and paging; LTE/NR co-existence in the same spectrum and the benefits of their interworking as one system; and different aspects of mobility in NR. RF requirements for NR are described for BS and UE, the legacy bands, and for the new mm-wave bands. Gives a concise and accessible explanation of the underlying technology and standards for 5G NR radio-access technology Provides detailed description of the NR physical-layer structure and higher-layer protocols, RF and spectrum aspects, and co-existence and interworking with LTE Gives insight not only into the details of the NR specification, but also an understanding of why certain solutions look like they do Includes the key radio-related requirements of NR, design principles, and technical features of basic NR transmission structure

Biomolecular Interactions: Part A, Volume 169, the latest release in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Emerging Mechanisms of Targeted Protein Degradation by Molecular Glues, Design and use of programmable DNA Hydrogels, Oligomerization of membrane receptors: Approaches to measure in live cells, Interactions of alpha-synuclein with biomolecules, Gel-electrophoresis based method for biomolecular interaction, Recombinant centrosome expression in bacterial system, Reconstituting CCL5-CCR5 complex for structural and mechanistic analysis, Protein engineering and design in ion channel receptors, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Updated release includes the latest information on biomolecular interactions instead of protein-protein interactions

**Selected for 2026 Doody's Core Titles in Molecular Biology**Diagnostic Molecular Biology, Second Edition provides an up-to-date comprehensive overview of the latest advances in molecular diagnostics and the fundamental molecular aspects in this area. The book delves into the essential principles behind the transmission and expression of genetic information, including nucleic acids, proteins, and chromosomes, specifically their genome structure, life cycle, and evolution. The latest methods and instrumentation in the field are examined with detailed procedures and explanations provided for each technique. A range of techniques are also investigated, such as those used in sequencing analysis, genome and transcriptome analysis, and nucleic acid amplitification techniques. This book covers the collection, isolation, and purification of DNA, RNA, and protein from different sources. Additionally, discussion on the applications of next-generation sequencing (NGS) and the role of NGS in the future of precision medicine is included. The book also examines the use of molecular diagnostics for chromosomal disorders, inherited diseases, and infectious diseases. Moreover, this new edition features recent advances in the detection of respiratory virus infections in humans, including that of SARS-CoV2. Diagnostic Molecular Biology, Second Edition, is an ideal reference for researchers, lab technicians, and students in medical laboratory science, molecular biology, microbiology, virology, and related fields.

Provides explanations on how techniques are used to diagnosis at the molecular level Explains how to use information technology to communicate and assess results in the lab Enhances our understanding of fundamental molecular biology and places techniques in context Places protocols into context with practical applications Includes extra chapters on respiratory viruses (Corona)

Extended Reality for Healthcare Systems: Recent Advances in Contemporary Research focuses on real world applications in medicine, also providing an overview of emerging technologies. The book includes case studies that break down the ways in which this technology has and can be used, while also taking readers through evidence, best practices and obstacles. Sections emphasize evidence, research-based practices and work. Content coverage includes Enhancing Medical Education with AR/VR, and XR: The Future of Surgery and Building Systems for Enhanced Health, and more. Readers will learn how to use this technology to improve existing systems by enhancing precision and reducing costs.

Other sections cover extended reality in elderly care and remote monitoring of patients, building systems for enhanced health, including telehealth and telepsychiatry, using AR and VR in medical education, and designing technology for use in telesurgery.

Offers advice on the development of state-of-the-art tech-driven healthcare systems and technologies for improving the quality of healthcare Focuses on healthcare solutions that are inclusive and cost-effective Discusses the future, limitations and challenges associated with the use and adoption of XR for healthcare