Transduction Mechanisms in Cellular Signaling

Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research. Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and Biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University, and Professor and Chair of the Department of Biological Chemistry, University of California Irvine. He presently is Professor of Pharmacology at the University of California, San Diego. He served as president of FASEB, was the founding president of the Protein Society and was the treasurer of the ASBMB. He was the founding editor of Molecular and Cellular Proteomics. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signaling. He has also studied the role of proteolytic processing and N-terminal modification in protein stability and turnover.

• Volume two includes 183 chapters divided in 8 sections, including:Section A: Protein Phosphorylation56 Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases57 Modular Protein Interaction Domains in Cellular Communication58 Structures of Serine/Threonine and Tyrosine Kinases59 Protein Tyrosine Kinase Receptor Signaling Overview60 Signaling by the Platelet-Derived Growth Factor Receptor Family61 The Epidermal Growth Factor Receptor Family62 Mechanisms and Functions of Eph Receptor Signaling63 Cytokine Receptor Signaling64 The Negative Regulation of JAK/STAT signaling65 Protein Kinase Inhibitors66 Integrin Signaling: Cell Migration, Proliferation, and Survival67 Downstream Signaling Pathways: Modular Interactions68 Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function69 Receptor Tyrosine Kinase Signaling and Ubiquitination70 TGFb Signal Transduction71 Mitogen-Activated Protein Kinases72 Recognition of Phospho-Serine/Threonine Phosphorylated Proteins 73 AMP-Activated Protein Kinase74 Principles of Kinase Regulation75 Calcium/Calmodulin-Dependent Protein Kinase II76 Glycogen Synthase Kinase 377 The PIKK Family of Protein Kinases78 Histidine Kinases in Two-Component Signaling Pathways79 The EF2K/MHCK/TRPM7 Family of Atypical Protein Kinases80 The Leucine-Rich Repeat Receptor Protein Kinases of Arabidopsis thaliana 81 Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors82 Clinical Applications of Kinase Inhibitors in Solid Tumors83 Ubiquitin-Mediated Regulation of Protein Kinases in NFκB Signaling84 Global Analysis of Phosphoregulatory NetworksSection B: Protein Dephosphorylation85 Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins86 The Structure and Topology of Protein Serine/Threonine Phosphatases87 Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases88 Protein Phosphatase 1 Binding Proteins89 Protein Serine/Threonine Phosphatase Inhibitors and Human Disease90 Calcineurin91 Protein Serine/Threonine-Phosphatase 2C (PP2C)92 Approaches to the Identification of Protein Tyrosine Phosphatase Substrates93 Inhibitors of Protein Tyrosine Phosphatases94 Regulating Receptor PTP Activity95 CD45