Biomolecular Interactions Part B

Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.

• 1. Emerging Mechanisms of Targeted Protein Degradation by Molecular Glues2. Design and use of programmable DNA Hydrogels3. Oligomerization of membrane receptors: Approaches to measure in live cells4. Interactions of alpha-synuclein with biomolecules5. Gel-electrophoresis based method for biomolecular interaction6. Recombinant centrosome expression in bacterial system7. Reconstituting CCL5-CCR5 complex for structural and mechanistic analysis8. Protein engineering and design in ion channel receptors9. The crosstalk of G-proteinsand phospholipases in cellular signaling10. Discovery of virus-host interactions using bioinformatics11. Measuring Ligand-receptor interactions at opioid receptors12. Label-free cell-based assays to unravel the biomolecular interactions involved in G-protein coupled receptor signaling13. Measuring ligand-receptorinteractionsusing Atomic Force Microscopy14. Reconstituting NTS1R signaling complex in lipid nanodisc15. Proximity labeling methods to study biomolecular interactions16. Super-resolution Microscopy approaches for monitoring protein trafficking and interaction17. Interaction of cytosolic proteins with synthetic antibody fragments using NanoBiT assays18. Reversible cross-linking to detect protein-protein interaction19. Assays to monitor the activity of atypical chemokine receptors