James T. O'Donnell – författare

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided.Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in ResearchContributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

O’Donnell’s Drug Injury, Fifth Edition presents up-to-date information on adverse events caused by drugs via direct pharmacological action or indirectly through injury caused by impairment or an altered mental state. The impact of drug injury on legal cases is emphasized throughout the book. This book serves as a comprehensive reference for attorneys, pharmacists, physicians, risk managers, nurses, drug manufacturers, and regulators—as well as anyone with an interest in drug use and drug injury. It lays out general pharmacological principles, presents an in-depth discussion of high-risk drugs often implicated in drug injury, details best practices to improve medication safety in clinical pharmacy practice, and discusses a variety of important forensic toxicology concepts such as drug testing.Key areas covered include:Pharmacology and toxicology of high-alert and high-risk drugs often implicated in legal casesApplication of pharmacological and toxicological principles to the lawCoverage of processes to ensure medication safety, gaps and blind spots in this process, and recommendations on how to enhance drug safetyEight new chapters covering timely topics such as Antineoplastics Therapy, Contrast Media Neurotoxicity, Drug Recognition Evaluation, RxISK Adverse Drug Reaction Reporting Program, Compounding Pharmacy Fraud, Involuntary Intoxication, and Total Parenteral Nutrition Errors and InjuriesContributions by 43 authors with diverse expertise, including pharmacologists; toxicologists; clinical pharmacists; physicians; attorneys; nephrologists, and a neurologist, hepatologist, epidemiologist, addiction expert, and an investigative health reporter