Leslie H. Sobin – författare

Prognostic Factors in Cancer, Third Edition examines the prognostic factors associated with each cancer site and provides insight into potential treatments and therapies. The text is an extension of the International Union Against Cancer's (UICC) seminal work, the TNM Classification of Malignant Tumours, and integrates the current focus on prognostics in cancer. This Third Edition reflects the advances in cancer diagnosis and treatment planning made in recent years. The first part of the book offers a complete update on the science of cancer prognosis while the second part contains site-specific chapters that provide evidence-based guidelines for treatment. Each clinical chapter summarizes the significance of the great variety of tumour-related, patient-related, and environment-related factors that play a role in the prognosis of cancer, all backed with a grid for quick reference.Visit TNM Online at: www.mrw.interscience.wiley.com/tnm to find the complete text of the previous edition of Prognostic Factors in Cancer, as well as other supplemental material related to cancer staging and predictive indicators.Prognostic Factors in Cancer, Third Edition is an invaluable resource for all oncologists and cancer researchers. The title is also of interest for other professionals such as pathologists and epidemiologists.

Wie schon in den vorherigen Supplements ist die 4. Auflage unverzichtbar zur korrekten und einheitlichen Verwendung der Klassifikation von malignen Tumoren. Erstmals wird hier dem Prognostic Factors Project ein Kapitel gewidmet. Unverzichtbar für alle Onkologen und Pathologen.

This classification is based primarily on the microscopic characteris­ tics of tumours. It is therefore concerned with the identification of cell types and histological patterns as seen by conventional light micro­ scopy. In general, time-honoured terms have been retained. Syn­ onyms are listed only if they have been widely used or if they are con­ sidered to be important for understanding the disease process. In such cases, the preferred term is given first, followed by the synonym in parentheses. The individuality of a tumour manifests itself principally in its histological appearance and the extent of spread at the time of diag­ nosis. This volume is concerned only with the histological classific­ ation of tumours. Anatomical extent or staging is covered in the TNM Classification.! The histological classification of a tumour de­ pends on two main parameters, typing and grading, and a number of additional parameters which may apply to selected examples. Histological Typing This divides tumours of a given organ into different types according to their direction of differentiation. Although this may frequently in­ dicate the underlying histogenesis of the tumour, it may be difficult or impossible to identify the cell of origin. Note is taken of the structure and function of cell types, as well as the overall growth pattern of the tumour, with the aim of matching these features to those of a normal tissue found in the same organ.

This is the revised edition of the WHO histological classification of oesophageal and gastric tumours. It reflects the important changes that have occurred since the first edition in the fields of lymphomas, endocrine tumours and the dysplasias as well as adding a number of newly described entities. it sets the international standard for the next decade.

This second edition includes a detailed histological classi-fication of tumours and tumour-like lesions of the gallblad-der and extrahepatic bile ducts and also describes the sa-lient histological features. It will facilitate pathologic,therapeutic and epidemiologic comparisons.

This 1993 supplement facilitates uniform application of the TNM classification. The supplement provides explanations and examples that will solve practical problems when using TNM on a daily basis. It spells out the requirements for pathological classification (pT, pN) and contains recommendations for classification of new tumour sites and entities which are not yet formally included in the TNM system. It also includes proposals for optimal expansion of TNM subsets where more detailed data are needed without altering the basic rules of the TNM classification.

This is a classification of tumours and tumour-like lesions of the liver. It is based primarily on the microscopic characteristics of the tumours, and is therefore concerned with morphologically identi- fiable cell types and histological patterns. The haematoxylin- and eosin-stained section remains the mainstay of morphological diag- nosis, but special histochemical stains are often helpful and have been referred to in the explanatory notes. Readers interested in specific special stains mentioned in the text should consult Labora- tory Methods in Histotechnology of the Armed Forces Institute of *Pathology, Washington, D. c., USA. 1 The results of immunohisto- chemical methods for identifying various tumour "markers" have also been noted whenever indicated. The present classification incorporates all the previously classi- fied tumours, but also includes several new lesions, viz. biliary papil- lomatosis, the fibrolamellar variant of hepatocellular carcinoma and epithelioid haemangioendothelioma. Several subtypes of hepato- blastoma are mentioned. A serous type of bile duct cystadenoma is described.The section on tumour-like lesions has been expanded to include focal fatty change and inflammatory pseudotumour. The section on adenomatous hyperplasia, including macroregenerative nodules, has been amplified. The number of photomicrographs has been increased from the original 56 to 150. Unlike the first edition, the photomicrographs in the second edition are mostly black and white. All are new and were taken of representative cases on file at the Armed Forces Institute of Pathology.