Dietary Supplements

Committe on the Framework for Evaluating the Safety of the Dietary Supplements, National Research Council

• 1 Front Matter; 2 Executive Summary; 3 1 Introduction and Background; 4 2 Approaches Used by Others and Existing Safety Frameworks; 5 3 The Framework; 6 4 Categories of Scientific Evidence--Human Information and Data; 7 5 Categories of Scientific Evidence--Animal Data; 8 6 Categories of Scientific Evidence--Information About Related Substances; 9 7 Categories of Scientific Evidence--In Vitro Data; 10 8 Interactions; 11 9 Vulnerable Groups and Prevalance of Use; 12 10 Scientific Principles for Integrating and Evaluating the Available Data; 13 11 Applying the Framework: Case Studies Using the Prototype Safety Monographs; 14 12 Factors Influencing Use of the Safety Framework; 15 13 Findings and Recommendations; 16 Appendix A: Existing Frameworks or Systems for Evaluating the Safety of Other Substances; 17 Appendix B: Scope of Work and Comments to Initial July 2002 Framework; 18 Appendix C: Plant Family Information; 19 Appendix D: Chaparral: Prototype Monograph Summary; 20 Appendix E: Glucosamine: Prototype Monograph Summary; 21 Appendix F: Melatonin: Prototype Monograph Summary; 22 Appendix G: Chromium Picolinate: Prototype Monograph Summary; 23 Appendix H: Saw Palmetto: Prototype Monograph Summary; 24 Appendix I: Shark Cartilage: Prototype Monograph Summary; 25 Appendix J: Prototype Focused Monograph: Review of Liver-Related Risks for Chaparral; 26 Appendix K: Protoype Focused Monograph: Review of Anti-Androgenic Risks of Saw Palmetto Ingestion by Women; 27 Appendix L: Acknowledgements; 28 Appendix M: Biographical Sketches of Commitee Members; 29 Index