Jagath C. Rajapakse - Böcker

During the 1980s and early 1990s there was signi?cant work in the design and implementation of hardware neurocomputers. Nevertheless, most of these efforts may be judged to have been unsuccessful: at no time have have ha- ware neurocomputers been in wide use. This lack of success may be largely attributed to the fact that earlier work was almost entirely aimed at developing custom neurocomputers, based on ASIC technology, but for such niche - eas this technology was never suf?ciently developed or competitive enough to justify large-scale adoption. On the other hand, gate-arrays of the period m- tioned were never large enough nor fast enough for serious arti?cial-neur- network (ANN) applications. But technology has now improved: the capacity and performance of current FPGAs are such that they present a much more realistic alternative. Consequently neurocomputers based on FPGAs are now a much more practical proposition than they have been in the past. This book summarizes some work towards this goal and consists of 12 papers that were selected, after review, from a number of submissions. The book is nominally divided into three parts: Chapters 1 through 4 deal with foundational issues; Chapters 5 through 11 deal with a variety of implementations; and Chapter 12 looks at the lessons learned from a large-scale project and also reconsiders design issues in light of current and future technology.

An introduction to machine learning methods and their applications to problems in bioinformatics Machine learning techniques are increasingly being used to address problems in computational biology and bioinformatics. Novel computational techniques to analyze high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. Machine learning techniques such as Markov models, support vector machines, neural networks, and graphical models have been successful in analyzing life science data because of their capabilities in handling randomness and uncertainty of data noise and in generalization.From an internationally recognized panel of prominent researchers in the field, Machine Learning in Bioinformatics compiles recent approaches in machine learning methods and their applications in addressing contemporary problems in bioinformatics. Coverage includes: feature selection for genomic and proteomic data mining; comparing variable selection methods in gene selection and classification of microarray data; fuzzy gene mining; sequence-based prediction of residue-level properties in proteins; probabilistic methods for long-range features in biosequences; and much more.Machine Learning in Bioinformatics is an indispensable resource for computer scientists, engineers, biologists, mathematicians, researchers, clinicians, physicians, and medical informaticists. It is also a valuable reference text for computer science, engineering, and biology courses at the upper undergraduate and graduate levels.

The development of neural networks has now reached the stage where they are employed in a large variety of practical contexts. However, to date the majority of such implementations have been in software. While it is generally recognised that hardware implementations could, through performance advantages, greatly increase the use of neural networks, to date the relatively high cost of developing Application-Specific Integrated Circuits (ASICs) has meant that only a small number of hardware neurocomputers has gone beyond the research-prototype stage. The situation has now changed dramatically: with the appearance of large, dense, highly parallel FPGA circuits it has now become possible to envisage putting large-scale neural networks in hardware, to get high performance at low costs. This in turn makes it practical to develop hardware neural-computing devices for a wide range of applications, ranging from embedded devices in high-volume/low-cost consumer electronics to large-scale stand-alone neurocomputers. Not surprisingly, therefore, research in the area has recently rapidly increased, and even sharper growth can be expected in the next decade or so.Nevertheless, the many opportunities offered by FPGAs also come with many challenges, since most of the existing body of knowledge is based on ASICs (which are not as constrained as FPGAs). These challenges range from the choice of data representation, to the implementation of specialized functions, through to the realization of massively parallel neural networks; and accompanying these are important secondary issues, such as development tools and technology transfer. All these issues are currently being investigated by a large number of researchers, who start from different bases and proceed by different methods, in such a way that there is no systematic core knowledge to start from, evaluate alternatives, validate claims, and so forth. FPGA Implementations of Neural Networks aims to be a timely one that fill this gap in three ways: First, it will contain appropriate foundational material and therefore be appropriate for advanced students or researchers new to the field. Second, it will capture the state of the art, in both depth and breadth and therefore be useful researchers currently active in the field. Third, it will cover directions for future research, i.e. embryonic areas as well as more speculative ones.

The field of bioinformatics has two main objectives: the creation and maintenance of biological databases, and the discovery of knowledge from life sciences data in order to unravel the mysteries of biological function, leading to new drugs and therapies for human disease. Life sciences data come in the form of biological sequences, structures, pathways, or literature. One major aspect of discovering biological knowledge is to search, predict, or model specific patterns of a given dataset, which have some relevance to an important biological phenomenon or another dataset. To date, many pattern recognition algorithms have been applied or catered to address a wide range of bioinformatics problems. The 2006 Workshop of Bioinformatics in Pattern Recognition (PRIB 2006) marks the beginning of a series of workshops that is aimed at gathering researchers applying pattern recognition algorithms in an attempt to resolve problems in computational biology and bioinformatics. This volume presentsthe proceedings of Workshop PRIB 2006 held in Hong Kong, China, on August 20, 2006. It includes 19 technical contributions that were selected by the Program Committee from 43 submissions. We give a brief introduction to pattern recognition in bioinformatics in the first paper. The rest of the volume consists of three parts. Part 1: signal and motif detection, and gene selection. Part 2: models of DNA, RNA, and protein structures. Part 3: biological databases and imaging.

This book constitutes the refereed proceedings of the 5th European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics, EvoBIO 2007, held in Valencia, Spain, April 2007. Coverage brings together experts in computer science with experts in bioinformatics and the biological sciences. It presents contributions on fundamental and theoretical issues along with papers dealing with different applications areas.