Bertil Schmidt - Böcker

Parallel Programming: Concepts and Practice provides an upper level introduction to parallel programming. In addition to covering general parallelism concepts, this text teaches practical programming skills for both shared memory and distributed memory architectures. The authors' open-source system for automated code evaluation provides easy access to parallel computing resources, making the book particularly suitable for classroom settings.

Covers parallel programming approaches for single computer nodes and HPC clusters: OpenMP, multithreading, SIMD vectorization, MPI, UPC++ Contains numerous practical parallel programming exercises Includes access to an automated code evaluation tool that enables students the opportunity to program in a web browser and receive immediate feedback on the result validity of their program Features an example-based teaching of concept to enhance learning outcomes

New sequencing technologies have broken many experimental barriers to genome scale sequencing, leading to the extraction of huge quantities of sequence data. This expansion of biological databases established the need for new ways to harness and apply the astounding amount of available genomic information and convert it into substantive biological understanding. A complilation of recent approaches from prominent researchers, Bioinformatics: High Performance Parallel Computer Architectures discusses how to take advantage of bioinformatics applications and algorithms on a variety of modern parallel architectures. Two factors continue to drive the increasing use of modern parallel computer architectures to address problems in computational biology and bioinformatics: high-throughput techniques for DNA sequencing and gene expression analysis—which have led to an exponential growth in the amount of digital biological data—and the multi- and many-core revolution within computer architecture.Presenting key information about how to make optimal use of parallel architectures, this book: Describes algorithms and tools including pairwise sequence alignment, multiple sequence alignment, BLAST, motif finding, pattern matching, sequence assembly, hidden Markov models, proteomics, and evolutionary tree reconstruction Addresses GPGPU technology and the associated massively threaded CUDA programming model Reviews FPGA architecture and programming Presents several parallel algorithms for computing alignments on the Cell/BE architecture, including linear-space pairwise alignment, syntenic alignment, and spliced alignment Assesses underlying concepts and advances in orchestrating the phylogenetic likelihood function on parallel computer architectures (ranging from FPGAs upto the IBM BlueGene/L supercomputer) Covers several effective techniques to fully exploit the computing capability of many-core CUDA-enabled GPUs to accelerate protein sequence database searching, multiple sequence alignment, and motif finding Explains a parallel CUDA-based method for correcting sequencing base-pair errors in HTSR dataBecause the amount of publicly available sequence data is growing faster than single processor core performance speed, modern bioinformatics tools need to take advantage of parallel computer architectures. Now that the era of the many-core processor has begun, it is expected that future mainstream processors will be parallel systems. Beneficial to anyone actively involved in research and applications, this book helps you to get the most out of these tools and create optimal HPC solutions for bioinformatics.

The advancements of computational and informational techniques have enabled in silico testing of many lab-based experiments in life sciences before performing them in in vitro or in vivo. Though computational techniques are not capable of mimicking all wet-lab experiments, bioinformatics will inevitably play a major role in future medical practice. For example, in the pursuit of new drugs it can reduce the costs and complexity involved in expensive wet-lab experiments. It is expected that by 2010, sequencing of individual genomes will be affordable generating an unprecedented increase of life sciences data, in the form of sequences, expressions, networks, images, literature. Pattern recognition techniques lie at the heart of discovery of new insights into biological knowledge, as the presence of particular patterns or structure is often an indication of its function. The aim of the workshop series Pattern Recognition in Bioinformatics (PRIB) is to bring pattern recognition scientists and life scientists together to promote pattern recognition applications to solve life sciences problems. This volume presents the proceedings of the 2nd IAPR Workshop PRIB 2007 held in Singapore, October 1–2, 2007. It includes 38 technical contributions that were selected by the International Program Committee from 125 submissions. Each of these rigorously reviewed papers was presented orally at the workshop. The proceedings consists of six parts. Part 1: Sequence Analysis; Part 2: Prediction of Protein Structure, Interaction, and Localization; Part 3: Gene Expression Analysis; Part 4: Pathway Analysis; Part 5: Medical Informatics; and Part 6: Bioimaging.