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This book reveals glimpses of how the quantum physics of atoms and molecules influences, and even controls, the way our cells function and how we and our fellow animals interact with our environment. Simply put, how birds fly and why grass grows.Certainly, biochemistry and molecular biology are the foundations for the biology of living cells, but there is more—quantum coherence and entanglement influencing the functioning of proteins and enzymes, and strictly speaking, without the quantum phenomena we wouldn’t even be here.In the end, however, this book is based on the solid ground of science, presenting the many fascinating phenomena of how quantum physics makes life possible without any unwarranted mystification.

This book reveals glimpses of how the quantum physics of atoms and molecules influences, and even controls, the way our cells function and how we and our fellow animals interact with our environment. Simply put, how birds fly and why grass grows.Certainly, biochemistry and molecular biology are the foundations for the biology of living cells, but there is more—quantum coherence and entanglement influencing the functioning of proteins and enzymes, and strictly speaking, without the quantum phenomena we wouldn’t even be here.In the end, however, this book is based on the solid ground of science, presenting the many fascinating phenomena of how quantum physics makes life possible without any unwarranted mystification.

This book provides a comprehensive overview of the fast-evolving subject of clinical application of cancer therapeutic biomarkers. The second edition captures significant progress of cancer immunotherapy and emphasizes the genetic basis for selective cancer treatment. It covers an in-depth insight on biomarkers across a broad area of cancer research and oncology with a wealth of integrated genetic and molecular information about specific therapies by a multidisciplinary team of internationally recognized experts. Each chapter focuses on a class of targeted, immunologic, or chemotherapy agents and their companion biomarkers that predict response, benefit or resistance, and severe adverse event. The book will serve as a handbook for health professionals and scientists on the current applicable biomarkers in the management of cancer. The vision into the systemic classification and statistical consideration of therapeutic biomarkers summarized by the book editors and chapter authors will help advance precision medicine—a precisely tailored cancer treatment strategy for cancer patient care.

Follow a multi-faceted journey by an improviser and a musicosopher, Eric Antoni, from the cobbled streets of Paris to the Far East. Musical Mosaic lays coherent excursus of the author’s thought-provoking collection of anecdotes. With the absence of lengthy verbiage of a political-social-economic nature, the book is full of compassionate truthful descriptions of persons and experiences and written with total objectivity, brevity, originality, and musical creativity as inspired by the sense of tonality, throughout the history of music in Europe, since Monteverdi, and all over the world nowadays. As a text that is "musico-sophical" instead of being "musico-logical," it is inspired by the founder of phenomenology, Edmund Husserl (1859–1938), and his philosophical seizure of consciousness. It discusses the author’s journey in the world of music and describes "musical consciousness" and the ways in which it moves and works within us. The book presents to the readers the author’s account of the composers he met along the way (Slamet Sjukur, Giacinto Scelsi) and the composers who are currently active (Jean-François Laporte, Pierre Michaud, Myriam Boucher, George Benjamin), along with historical narratives that center around Monteverdi, Bach, Ravel, Debussy, and Bartók. It underlines the interrogations held by today’s musicians in light of yesterday’s mutations. With this book, the author would like to reach out to composers, performers, and music lovers and contribute towards opening them to the scope of experimentation in music and in the world of sound, all of which keep on becoming more expansive and more intensely conscious.

Currently, light waves are ready to come into boxes of computers in high-performance computing systems like data centers and super computers to realize intra-box optical interconnects. For inter-box optical interconnects, light waves have successfully been introduced by OE modules, in which discrete bulk-chip OE/electronic devices are assembled using the flip-chip-bonding-based packaging technology. OE modules, however, are not applicable to intra-box optical interconnects, because intra-box interconnects involve “short line distances of the cm–mm order” and “large line counts of hundreds-thousands.” This causes optics excess, namely, excess components, materials, spaces, fabrication efforts for packaging, and design efforts. The optics excess raises sizes and costs of intra-box optical interconnects enormously when they are built using conventional OE modules. This book proposes the concept of self-organized 3D integrated optical interconnects and the strategy to reduce optics excess in intra-box optical interconnects.

Mullite is the most important crystalline phase in fired products belonging to the Al2O3–SiO2 mullite system, such as whiteware articles used in daily life (e.g., low- and high-temperature hard porcelain, sanitaryware, and structural clay products). Mullite has attracted increasing interest due to its excellent high-temperature strength and creep resistance, good chemical and thermal stability, low thermal expansion coefficient, and good dielectric properties. Mullitization has been a subject of extensive and controversial investigations. This book comprehensively covers the synthesis and six types of phase transformation of mullite. Part I reviews previous research on the synthesis of mullite gels, advantages and disadvantages of different chemical routes of synthesis, and phase transformation processes. Part II discusses the nature and characterization of spinel and mullite phases and different mechanisms of mullite formation, as conjectured by various researchers. Part III deals with the critical analysis of the spinel and mullite phases and evolution of mullite formation routes. Every chapter is accompanied by detailed diagrams and a comprehensive list of references.

The usage of building energy accounts for 30–40% of total energy consumption in developed countries, exceeding the amount for industry or transportation. Around 50% energy for building services is contributed by heating, ventilation, and air-conditioning (HVAC) systems. More importantly, both building and HVAC energy consumptions are predicted to increase in the next two decades. Windows are considered as the least energy-efficient components of buildings. Therefore, smart windows are becoming increasingly important as they are capable of reducing HVAC energy usage by tuning the transmitted sunlight in a smart and favoured way: blocking solar irradiation on hot days, while letting it pass through on cold days. Compared with other type of smart windows, thermochromic windows have the unique advantages of cost-effectiveness, rational stimulus, and passive response. This book covers fabrication of vanadium dioxide–based smart windows, discusses various strategies to enhance their performance, and shares perspectives from the top scientists in this particular field.

Titanium dioxide (TiO2) has drawn considerable attention as an attractive inorganic raw material for various applications due to its inexpensiveness, nontoxic nature, stability, and excellent photocatalytic activity. Photocatalysis is one of the most promising route for sustainable chemistry of the 21st century. It can contribute to solving environmental, global energy, and chemical problems, as well as to the sustainable production of commodities in the near future.This book presents the fundamentals of photocatalysis in nanostructured TiO2 and describes the factors affecting the photocatalytic activity, design, and synthesis of various forms of nanostructured TiO2. It highlights the use of ion-doping and inert-atmosphere annealing to extend the light-absorption range of photocatalysts and reduce recombination between electrons and holes. It discusses numerous applications in the fields of energy and environment, such as water purification, gas sensing, storage and delivery, and energy generation. The book is an invaluable resource and useful guide for a broad readership in various fields of catalysis, materials science, environment, and energy.

The primary goal of nanotechnology is to achieve nanoscale materials and devices with atomic precision. Toward this goal, breakthroughs have recently been made in the solution-phase synthesis and applications of atomically precise nanoclusters. This book presents the exciting progress in this new research field. The chapters are contributed by leading experts of the field and cover the synthetic methods, atomic structures, electronic and optical properties, and catalytic applications of noble metal nanoclusters. Such new nanocluster materials offer exciting opportunities for chemists and physicists to understand the fundamental science of nanoclusters, especially the atomic-level structure–property correlation and design of new materials, as well as for developing a range of applications including catalysis, biomedicine, sensing, imaging, optics, and energy conversion. The book will be of interest to readers and researchers in nanotechnology, nanochemistry, catalysis, and computational chemistry, as well as practitioners in industry R&D for new materials. It is written to be accessible to undergraduate and graduate students and, therefore, is an excellent teaching material.

In this book, the fundamentals of micro- and nanofabrication are described on the basis of the concept of “using gases as a fabrication tool.” Unlike other books available on the subject, this volume assumes only entry-level mathematics, physics, and chemistry of undergraduates or high-school students in science and engineering courses. Necessary theories are plainly explained to help the reader learn about this new attractive field and enable further reading of specialized books. The book is an attractive guide for students, young engineers, and anyone getting involved in micro- and nanofabrication from various fields including physics, electronics, chemistry, and materials sciences.

Heterostructured (HS) materials represent an emerging class of materials that are expected to become a major research field for the communities of materials, mechanics, and physics in the next couple of decades. One of the biggest advantages of HS materials is that they can be produced by large-scale industrial facilities and technologies and therefore can be commercialized without the scaling up and high-cost barriers that are often encountered by other advanced materials. This book collects recent papers on the progress in the field of HS materials, especially their fundamental physics. The papers are arranged in a sequence of chapters that will help new researchers entering the field to have a quick and comprehensive understanding of HS materials, including the fundamentals and recent progress in their processing, characterization, and properties.

This book presents a comprehensive review of research on applications of carbon nanotubes (CNTs) and graphene to electronic devices. As nanocarbons in general, and CNTs and graphene in particular, are becoming increasingly recognized as the most promising materials for future generations of electronic devices, including transistors, sensors, and interconnects, a knowledge gap still exists between the basic science of nanocarbons and their feasibility for cost-effective product manufacturing. The book highlights some of the issues surrounding this missing link by providing a detailed review of the nanostructure and electronic properties, materials, and device fabrication and of the structure–property–application relationships.

The era of Sustainable and Energy Efficient Nanoelectronics and Nanosystems has come. The research and development on Scalable and 3D integrated Diversified functions together with new computing architectures is in full swing. Besides data processing, data storage, new sensing modes and communication capabilities need the revision of process architecture to enable the Heterogeneous co integration of add-on devices with CMOS: the new defined functions and paradigms open the way to Augmented Nanosystems. The choices for future breakthroughs will request the study of new devices, circuits and computing architectures and to take new unexplored paths including as well new materials and integration schmes.This book reviews in two sections, including seven chapters, essential modules to build Diversified Nanosystems based on Nanoelectronics and finally how they pave the way to the definition of Nanofunctions for Augmented Nanosystems.

This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase, related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer, β-Lactams and related compounds as antibacterials, non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases, and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy.

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.

In recent years, optical properties of the unique atomic and molecular structures of materials have drawn great scientific interest. Linear optical properties of materials such as metals, metal oxides, magnetic oxides, and organic materials are based on energy transfer and find applications in wastewater treatment, forensic science, biomedical science, photovoltaics, nuclear technology, and LED displays. Nonlinear optical properties of materials are based on the nonlinear medium and find more advanced applications in frequency mixing generations and optical parametric oscillations. This book presents the underlying principles, implementation, and applications of the linear and nonlinear optical properties of materials and has been divided into two parts emphasizing these properties. The first part of the book, Linear Optics, discusses bimetallic nanoparticles in dielectric media and their integration to dye molecules to detect trace amounts of heavy metals at the nanometer level, as well as to enhance luminescence and image contrasts in forensic inspection and biomedical diagnosis. It shows how the integration of bimetallic nanoparticles into a ZnO matrix promotes broadening of the absorption spectrum from the ultraviolet to the visible wavelength. It explains the role of surface adsorption and photocatalytic degradation in dye-removal kinetics by Fe3O4 magnetic nanoparticles under pulsed white light. It also discusses the double-layer shielding tank design to safely store radioactive waste and photon propagation through the multilayer structures of a human tissue model. The second part of the book, Nonlinear Optics, presents general concepts such as electromagnetic theory, nonlinear medium, and wave propagation, as well as more advanced concepts such as second harmonic generation, phase matching, optical parametric interactions, different frequency generation, sum frequency generation, tunable laser, and optical resonant oscillator.

Every electrochemical source of electric current is composed of two electrodes with an electrolyte in between. Since storage capacity depends predominantly on the composition and design of the electrodes, most research and development efforts have been focused on them. Considerably less attention has been paid to the electrolyte, a battery’s basic component. This book fills this gap and shines more light on the role of electrolytes in modern batteries. Today, limitations in lithium-ion batteries result from non-optimal properties of commercial electrolytes as well as scientific and engineering challenges related to novel electrolytes for improved lithium-ion as well as future post-lithium batteries.

Pullulan is a polysaccharide produced by the fungus Aureobasidium pullulans and possesses some distinct properties such as excellent transparent film–forming ability, moisture absorptivity, water solubility, non-toxicity, and adhesivity. These properties allow pullulan to find potential applications in various industries such as pharmaceuticals, cosmetics, food, and health care.This book presents the chemistry and properties of pullulan, along with the method of its production at the laboratory level. It discusses the structural engineering, processing methods, and versatile applications of pullulan, as well as highlights the challenges that still have to be overcome for its large-scale production. This unique book comprehensively summarizes many of the recent research findings on pullulan, contributed by leading experts in this research domain. It is a useful reference book for scientists, academicians, researchers, chemists, technologists, graduate and postgraduate students, and general readers who are interested in pullulan.

This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the works herein began assessing their structure-activity relationships. This collection chronologically follows the path of investigating the recognition of design components to implementing them into nucleic acid nanostructures.RNA nanotechnology is an emerging platform for therapeutics with increasing clinical relevance as this approach becomes more widely used and approved for the treatment of various diseases. The latest research aims to take advantage of RNA’s modular nature for the design of nanostructures which can interact with their environments to communicate programmed messages with intracellular pathways. In doing so, nanoparticles can be used to elicit or elude responses by the immune system as desired in conjunction with their therapeutic applications.

An impending energy crisis is looming globally, which has led to the use of effluents from paper mills for enhanced oil recovery (EOR), CO2 flooding and wastewater treatment by biosurfactants, and the current market demand for cost-competitive and environment-friendly alternatives to synthetic chemicals. This up-to-date book on petroleum technology provides a comprehensive review of the background and recent advances in the field of petroleum technology and highlights various facets of the fascinating world of upstream, midstream and downstream petroleum technologies. It comprises 25 chapters, each representing the progress, prospects and challenges in petroleum research, and focuses on the tremendous progress made by the scientific community in this research field. The book covers in detail EOR processes, reservoir engineering, production operation and optimisation, pipeline transportation and storage, CO2 capture and sequestration, wastewater management and innovative treatment, refining technologies, environmental chemistry, and biochemistry and biotechnology for the petroleum industry.

Surely the reader had come across situations where he would have given his life to get the “final answer”, the reason for our existence, a Theory of Everything, a true World Formula that contains it all… So did the author of this book. There was this deep-seated and forever unquenchable thirst for fundamental explanations on the one hand, and then there was this very special motivation from somebody else who needed this knowledge, on the other: “How to explain the world to my dying child?” Perhaps this provided the driving force to actually start this million-mile-long journey with the first small—and very tentative—step.Considering all the efforts taken, money spent, disputes fought, papers and books written, and conferences held, it is almost shocking to find that, in principle, the World Formula was already there. It was David Hilbert who wrote it down during World War I in November 1915. The complexity of the math involved was not the only thing that obscured what should have been obvious. This book explains why apparently only very few people had realized his immortal stroke of genius.

Unraveling the mystery of the negative thermal expansion of liquid water has been a challenge for scientists for centuries. Various theories have been proposed so far, but none has been able to solve this mystery. Since the thermodynamic properties of matter are determined by the interaction between particles, the mystery can be solved fundamentally if the thermodynamic physical quantities using the laws of thermodynamics and statistical mechanics are determined, the experimental results are reproduced, and the phenomena in relation to the shape of the interaction between particles are elucidated. In this sense, this book has fundamentally unraveled this mystery. In addition, it discusses the mysteries of isothermal compressibility, structural diversity, as well as liquefaction and boiling points of water in relation to the shape of the interaction between particles. It carefully explains the analysis and calculation methods so that they can be easily understood by the readers.

Cancer remains one of the most challenging issues in modern medicine, being responsible for a high number of deaths every year. Recent important developments in cancer diagnosis and therapy based on the versatility of nanosystems have made it possible to incorporate multifunctional synergistic actions into a single delivery system.This book compiles the research on the use of functional lipid nanosystems that combine different strategies in one single nanosystem to enhance overall cancer treatment. Besides providing an overview of the current functional nanosystem strategies, it also offers researchers essential theoretical background on cancer, the physiological barriers to its treatment, aspects related to the design and optimization of nanocarriers for cancer treatment, and clinical developments, including promises, safety issues, and the expected future. The editors bring together a group of scientists from all over the world to discuss the most relevant issues and to provide updates on functional lipid nanosystems and cancer.

LIG is a revolutionary technique that uses a common CO2 infrared laser scriber, like the one used in any machine shop, for the direct conversion of polymers into porous graphene under ambient conditions. This technique combines the preparation and patterning of 3D graphene in a single step, without the use of wet chemicals. The ease in the structural engineering and excellent mechanical properties of the 3D graphene obtained have made LIG a versatile technique for applications across many fields.This book compiles cutting-edge research on LIG by different research groups all over the world. It discusses the strategies that have been developed to synthesize and engineer graphene, including controlling its properties such as porosity, composition, and surface characteristics. The authors are pioneers in the discovery and development of LIG and the book will appeal to anyone involved in nanotechnology, chemistry, environmental sciences, and device development, especially those with an interest in the synthesis and applications of graphene-based materials.

Silica is one of the key materials in many modern technological applications. Further miniaturization of nanoelectronic devices necessitates rational design of ultrathin silica films on electrically conductive substrates. This is the first-ever book on the preparation and atomic-level description of ultrathin silica films grown on metal substrates. Experimental and theoretical studies performed in recent years provide compelling evidence of the growth of well-ordered silica films that exhibit the structural motif of sheet silicates. A growing body of research suggests that a singlelayer silicate, which received the name silicatene by analogy with the famous graphene, should be included in the family of truly two-dimensional materials. In addition, the silicate films modified with metals such as Al and Fe offer a unique possibility to study the surface structures (and hence the surface chemistry) of natural silicates, e.g., clays and zeolites. Finally, ultrathin silica films represent well-defined model systems for elucidating the mechanism of crystal-glass transitions.

If observed from an objective, epistemological standpoint, medicine is not a science, at least not in its own right. The most important, key feature missing is repeatability, which makes the doctor’s job extremely difficult. Doctors are not scientists but are called upon to use the results of scientific research every day. Therefore, they must keep themselves updated, distinguish what is worth extricating from a huge amount of literature and use the data exclusively in the patients’ interest. To be effective, medicine must start from a correct, full understanding of problems, but particulate pollution leads to too many wrong diagnoses. This book, written by the discoverers of nanopathology, is the most advanced in the field. It focuses on how natural, occasionally generated, engineered particles interfere with living organisms, food, drugs and the environment. It represents a bridge between environmental pollution and its impact on human/animal/plant health. Also unique is its new bioengineering-interdisciplinary approach to medicine and solving pathologies of unknown aetiology. It is a valuable aid for medical doctors in their diagnoses of pathologies triggered by nanoparticles internalized in the human/animal/plant body. They will find solutions to some hardly understandable symptoms which some patients report.

Professionals recognize entropy-enthalpy compensation as an important factor in molecular recognition, lead design, water networks, and protein engineering. It can be experimentally studied by proper combinations of diverse spectroscopic approaches with isothermal titration calorimetry and is clearly related to molecular dynamics. So, how should we treat entropy-enthalpy compensation? Is it a stubborn hindrance that solely complicates the predictability of phenomena otherwise laid on the line by Mother Nature? How should we then deal with it? This book dwells on these posers. It combines two chapters written by globally recognized specialists. Chapter 1 deals with general issues and suggests a definite approach to how we may answer the posers. Chapter 2 shows how the approach outlined might be successfully applied in a rational design of enzymes. This might provide other interesting strategic perspectives in the general theoretical physical chemistry field.

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

Heterophase polymerization is a century-old technology with a wide range of relevant industrial applications, including coatings, adhesives, rubbers, and many other specialized biomedical and high-performance materials. However, due to its multiscale complexity, it still remains a challenging research topic. It is a broad field covering all heterogeneous polymerization processes that result in polymer dispersions. Its technical realizations comprise emulsion polymerization, dispersion polymerization, suspension polymerization, miniemulsion polymerization, microemulsion polymerization, and others. This book is devoted to the science and technology of heterophase polymerization, considering it a generic term as well as an umbrella expression for all of its technical realizations. It presents, from a modern perspective, the basic concepts and principles required to understand the kinetics and thermodynamics of heterophase polymerization at the atomistic, molecular, macromolecular, supramolecular, colloidal, microscopic, mesoscopic, and macroscopic scales. It critically discusses the important physicochemical mechanisms involved in heterophase polymerization, such as nucleation, particle aggregation, mass transfer, swelling, spontaneous emulsification, and polymerization kinetics, along with the experimental evidences at hand.