Bengt Nordén – författare

The aim of this book is to provide an introduction to all those who wish to use the complementary spectroscopic techniques of optical activity (circular dichroism, CD) and optical anisotropy (linear dichroism, LD) for the study of the structure of molecules and interactions between molecules in solution. The emphasis of the book is on what the techniques are and how to use them for both low and high molecular weight molecules. It is intended to be an easy guide to what a prospective user of CD needs to know and explains how LD is not merely an exotic technique only to be practised by experienced spectroscopists, but may be routinely and usefully employed as an aid to molecular structure determination.Circular Dichroism and Linear Dichroism is the first book that is an easy, directly applicable manual to the use and interpretation of both CD and LD. It will be of use to both novices and experienced researchers in the field.

This book provides an introduction to optical anisotropy (linear dichroism, LD) and optical activity (circular dichroism, CD) as techniques for the study of structures and interactions of molecules in solution. The book covers the use of these techniques for both small and large molecular systems with particular emphasis being placed on proteins and nucleic acids. CD is a well-established technique and this book aims to explain how it can be used simply and effectively for new entrants to the field as well as covering more advanced techniques for experts. LD is often seen as a rather exotic method intended only for experienced spectroscopists. This book demonstrates that it is an approach with real utility that may be used by both students and scientists from graduate level onwards to give simple answers, which are not available from any other technique, to structural and kinetic questions. Much of the emphasis is on flow orientation of samples in solution phase. The book first describes the techniques and the information they can provide; it then goes on to give specific details on how to actually implement them, including a wide range of examples showing how LD and CD can help with * protein and nucleic acid secondary structure elucidation; * analysis of the formation and rearrangements of fibrous proteins and membrane proteins; * identification of the absolute configuration of small molecules; * determination of the orientation of small molecules in anisotropic media; * assignment of transition moment polarizations; * investigation of binding strengths and geometries of ligand-macromolecule complexes; * 3-D structure determination from LD, molecular replacement and MD modeling. The advantages of combined LD/CD studies are also outlined with examples of DNA/drug complexes and protein insertion into membranes. Taken together the book represents a comprehensive text on the theory and application of LD and CD in the chemical and biological sciences.

Mentioned as the second prize area in his will, Chemistry was the most important science for Alfred Nobel's own work. The development of Nobel's inventions as well as the industrial processes he employed were based upon chemical knowledge. This volume is a collection of the Nobel lectures delivered by the prizewinners, together with their biographies and the presentation speeches for the period 2006-2010. Each Nobel lecture is based on the work for which the laureate was awarded the prize.

Professionals recognize entropy-enthalpy compensation as an important factor in molecular recognition, lead design, water networks, and protein engineering. It can be experimentally studied by proper combinations of diverse spectroscopic approaches with isothermal titration calorimetry and is clearly related to molecular dynamics. So, how should we treat entropy-enthalpy compensation? Is it a stubborn hindrance that solely complicates the predictability of phenomena otherwise laid on the line by Mother Nature? How should we then deal with it? This book dwells on these posers. It combines two chapters written by globally recognized specialists. Chapter 1 deals with general issues and suggests a definite approach to how we may answer the posers. Chapter 2 shows how the approach outlined might be successfully applied in a rational design of enzymes. This might provide other interesting strategic perspectives in the general theoretical physical chemistry field.

Mentioned as the second prize area in his will, Chemistry was the most important science for Alfred Nobel's own work. The development of Nobel's inventions as well as the industrial processes he employed were based upon chemical knowledge. This volume is a collection of the Nobel lectures delivered by the prizewinners, together with their biographies and the presentation speeches for the period 2006-2010. Each Nobel lecture is based on the work for which the laureate was awarded the prize.

World Scientific has the exclusive rights to publish in English the latest collection of the Nobel lectures, the prize presentation speeches and the biographies of the Nobel Laureates for the years 2006-2010 in Physics, Chemistry, Physiology or Medicine, Literature, and Economic Sciences.The lectures offer a unique historical perspective of scientific and cultural developments in each of the respective fields, and would appeal to a wide range of readers. Each volume is a collection of the Nobel lectures delivered by the prizewinners, together with their biographies and the presentation speeches.Apart from serving as an invaluable source of information for specialists and researchers, the lectures would also be of interest to those with less specialised knowledge of the particular fields. This collection of inspiring lectures should be on the bookshelf of every student, teacher and professor, and would make an excellent source of reference for libraries and educational institutions.Also available are the Nobel Lectures for the years 1901-2005 in Physics, Chemistry, Physiology or Medicine, Literature, Peace, and 1969-2005 in Economic Sciences.In 5 volumes: Nobel Lectures in Physics (2006-2010) Nobel Lectures in Chemistry (2006-2010) Nobel Lectures in Physiology or Medicine (2006-2010) Nobel Lectures in Literature (2006-2010) Nobel Lectures in Economic Sciences (2006-2010)