Diagnostic Pathology: Spleen

Aaron Auerbach, MD, MPH, is the senior hematopathologist at the Joint Pathology Center in Silver Spring, Maryland, where he delivers expertise in both hematopathology and gastrointestinal pathology. He is the author of the prior and upcoming editions of Diagnostic Pathology: Molecular Oncology (2019 and 2023), and the sole author of Diagnostic Pathology: Spleen (2022).

"This book has grown since the first edition to maintain its standing as a comprehensive text (including 14 new chapters). Overall, this book provides all the essential knowledge on splenic pathology in one single resource. It is ideal for daily use as a reference but is also an excellent training resource for learners." ©Doody's Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 5 Stars!

• SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEENNORMAL HISTOLOGY4 Introduction to SpleenMohammad A. Vasef, MD and Jeremy C. Wallentine, MD12 Imaging of Splenic DisordersMohammad A. Vasef, MD18 Handling, Processing, and Gross Pathology of SpleenMohammad A. Vasef, MD26 Fine-Needle Aspiration and Core Biopsy of SpleenMohammad A. Vasef, MD32 Immunohistochemistry of SpleenAaron Auerbach, MD, MPH40 Flow CytometryNadine Aguilera, MD46 Molecular TechniquesNadine Aguilera, MDSECTION 2: NONNEOPLASTIC SPLENIC DISORDERSLYMPHOID HYPERPLASIA54 Florid Follicular HyperplasiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH56 Autoimmune DiseaseNadine Aguilera, MD62 HIV in SpleenNadine Aguilera, MD68 Castleman DiseaseNadine Aguilera, MD70 Marginal Zone HyperplasiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPHGRANULOMATOUS LESIONS/DISORDERS72 LipogranulomasJeffrey Vos, MD78 SarcoidosisEllina Hall, DO and Aaron Auerbach, MD, MPH82 Chronic Granulomatous DiseaseAaron Auerbach, MD, MPHINFECTIONS86 MycobacteriosisNadine Aguilera, MD 90 Selected Bacterial Infections Aaron Auerbach, MD, MPH 94 Candidiasis Aaron Auerbach, MD, MPH96 HistoplasmosisNadine Aguilera, MD98 CryptococcosisNadine Aguilera, MD100 CoccidioidomycosisAaron Auerbach, MD, MPH104 PneumocystosisAaron Auerbach, MD, MPH108 Infectious MononucleosisNadine Aguilera, MD112 Cytomegalovirus InfectionNadine Aguilera, MD114 Herpes Simplex Virus InfectionAaron Auerbach, MD, MPH and Nadine Aguilera, MD116 EchinococcosisAaron Auerbach, MD, MPH120 MalariaNadine Aguilera, MDNONINFECTIOUS CYSTS122 Epithelial CystEllina Hall, DO and Aaron Auerbach, MD, MPH124 False CystEllina Hall, DO and Aaron Auerbach, MD, MPHNONNEOPLASTIC VASCULAR PROCESSES126 Chronic Passive CongestionEllina Hall, DO and Aaron Auerbach, MD, MPH128 InfarctJeffrey Vos, MD136 PeliosisEllina Hall, DO and Aaron Auerbach, MD, MPH138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MDRED CELL DISORDERS144 Sickle Cell DiseaseAaron Auerbach, MD, MPH and Ellina Hall, DO146 ThalassemiaNadine Aguilera, MD and Aaron Auerbach, MD, MPH150 Hereditary SpherocytosisNadine Aguilera, MD152 Thrombotic Thrombocytopenic PurpuraAaron Auerbach, MD, MPHMISCELLANEOUS LESIONS/DISORDERS158 Heterotaxy SyndromesAaron Auerbach, MD, MPH160 Congenital Splenic AbnormalitiesNadine Aguilera, MD164 Extramedullary HematopoiesisEllina Hall, DO and Aaron Auerbach, MD, MPH166 Gamna-Gandy BodiesNadine Aguilera, MD168 Hemophagocytic LymphohistiocytosisNadine Aguilera, MD174 Immune Thrombocytopenic PurpuraEllina Hall, DO and Aaron Auerbach, MD, MPH178 Niemann-Pick DiseaseMeenakshi A. Nandedkar, MD and Nadine Aguilera, MD184 Gaucher DiseaseMeenakshi A. Nandedkar, MD and Nadine Aguilera, MD188 Sea-Blue (Ceroid) HistiocytosisMohammad A. Vasef, MD192 Gangliosidosis Lysosomal DisorderMohammad A. Vasef, MD194 Therapy Effect on SpleenAaron Auerbach, MD, MPH202 Traumatic and Nontraumatic Splenic InjuriesMohammad A. Vasef, MDSECTION 3: NEOPLASTIC SPLENIC DISORDERSBENIGN MESENCHYMAL LESIONS208 Introduction to Vascular LesionsNadine Aguilera, MD210 HemangiomaNadine Aguilera, MD218 LymphangiomaNadine Aguilera, MD222 Littoral Cell AngiomaNadine Aguilera, MD228 Inflammatory PseudotumorRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD236 Postchemotherapy Histiocyte-Rich Pseudotumor of SpleenRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD242 Splenic HamartomaNadine Aguilera, MD246 MyelolipomaAaron Auerbach, MD, MPHMALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS 248 AngiosarcomaNadine Aguilera, MD256 HemangioendotheliomaNadine Aguilera, MD258 Kaposi SarcomaNadine Aguilera, MD260 LeiomyosarcomaAaron Auerbach, MD, MPH266 Gastrointestinal Stromal TumorAaron Auerbach, MD, MPH272 Follicular Dendritic Cell SarcomaAaron Auerbach, MD, MPH280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell SarcomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD286 Langerhans Cell HistiocytosisGuanghua Wang, MD292 Histiocytic SarcomaNadine Aguilera, MDLYMPHOMA300 Introduction to LymphomaMohammad A. Vasef, MD310 Splenic Marginal Zone LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD318 Hairy Cell LeukemiaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD326 Hairy Cell Leukemia VariantRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD334 Lymphoplasmacytic LymphomaAaron Auerbach, MD, MPH342 Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD350 Follicular LymphomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD358 Mantle Cell LymphomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD366 Leukemic Nonnodal Mantle Cell LymphomaMohammad A. Vasef, MD370 Splenic Diffuse Red Pulp B-Cell LymphomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD376 B-Cell Prolymphocytic LeukemiaAaron Auerbach, MD, MPH and Nadine Aguilera, MD378 Diffuse Large B-Cell LymphomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False CystMohammad A. Vasef, MD390 T-Cell/Histiocyte-Rich Large B-Cell LymphomaJeffrey Vos, MD398 Burkitt LymphomaAaron Auerbach, MD, MPH406 Classic Hodgkin LymphomaJeffrey Vos, MD416 Nodular Lymphocyte-Predominant Hodgkin LymphomaAaron Auerbach, MD, MPH426 Peripheral T-Cell Lymphoma, UnspecifiedMohammad A. Vasef, MD432 Hepatosplenic T-Cell LymphomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD440 T-Cell Prolymphocytic LeukemiaMohammad A. Vasef, MD448 T-Cell Large Granular Lymphocytic Leukemia Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD456 Aggressive NK-Cell LeukemiaAaron Auerbach, MD, MPH462 Transformation of Splenic DisordersNadine Aguilera, MDLEUKEMIA466 Acute Myeloid LeukemiaNadine Aguilera, MD474 Lymphoblastic Leukemia/LymphomaNadine Aguilera, MDCHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES480 Myeloproliferative Neoplasm OverviewNadine Aguilera, MD482 Chronic Myeloid Leukemia, BCR::ABL1 PositiveNadine Aguilera, MD488 Essential ThrombocythemiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH492 Polycythemia VeraGuanghua Wang, MD496 Primary MyelofibrosisJeffrey Vos, MD506 MastocytosisMohammad A. Vasef, MD514 Chronic Myelomonocytic LeukemiaMohammad A. Vasef, MDPLASMA CELL-ASSOCIATED DISORDERS520 AmyloidosisNadine Aguilera, MD526 Heavy Chain DiseaseAaron Auerbach, MD, MPH530 Plasma Cell Myeloma/PlasmacytomaNadine Aguilera, MD and Aaron Auerbach, MD, MPHMETASTASIS534 Metastatic TumorsEllina Hall, DO and Aaron Auerbach, MD, MPH