Aaron Auerbach, MD, MPH, is the senior hematopathologist at the Joint Pathology Center in Silver Spring, Maryland, where he delivers expertise in both hematopathology and gastrointestinal pathology. He is the author of the prior and upcoming editions of Diagnostic Pathology: Molecular Oncology (2019 and 2023), and the sole author of Diagnostic Pathology: Spleen (2022).

"This book has grown since the first edition to maintain its standing as a comprehensive text (including 14 new chapters). Overall, this book provides all the essential knowledge on splenic pathology in one single resource. It is ideal for daily use as a reference but is also an excellent training resource for learners." -©Doody’s Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 5 Stars!

• SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEENNORMAL HISTOLOGY4 Introduction to SpleenMohammad A. Vasef, MD and Jeremy C. Wallentine, MD12 Imaging of Splenic DisordersMohammad A. Vasef, MD18 Handling, Processing, and Gross Pathology of Spleen26 Fine-Needle Aspiration and Core Biopsy of Spleen32 Immunohistochemistry of SpleenAaron Auerbach, MD, MPH40 Flow CytometryNadine Aguilera, MD46 Molecular TechniquesSECTION 2: NONNEOPLASTIC SPLENIC DISORDERSLYMPHOID HYPERPLASIA54 Florid Follicular HyperplasiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH56 Autoimmune Disease62 HIV in Spleen68 Castleman Disease70 Marginal Zone HyperplasiaGRANULOMATOUS LESIONS/DISORDERS72 LipogranulomasJeffrey Vos, MD78 SarcoidosisEllina Hall, DO and Aaron Auerbach, MD, MPH82 Chronic Granulomatous DiseaseINFECTIONS86 MycobacteriosisNadine Aguilera, MD 90 Selected Bacterial InfectionsAaron Auerbach, MD, MPH 94 Candidiasis96 Histoplasmosis98 Cryptococcosis100 Coccidioidomycosis104 Pneumocystosis108 Infectious Mononucleosis112 Cytomegalovirus Infection114 Herpes Simplex Virus InfectionAaron Auerbach, MD, MPH and Nadine Aguilera, MD116 Echinococcosis120 MalariaNONINFECTIOUS CYSTS122 Epithelial Cyst124 False CystNONNEOPLASTIC VASCULAR PROCESSES126 Chronic Passive Congestion128 Infarct136 Peliosis138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MDRED CELL DISORDERS144 Sickle Cell DiseaseAaron Auerbach, MD, MPH and Ellina Hall, DO146 ThalassemiaNadine Aguilera, MD and Aaron Auerbach, MD, MPH150 Hereditary Spherocytosis152 Thrombotic Thrombocytopenic PurpuraMISCELLANEOUS LESIONS/DISORDERS158 Heterotaxy Syndromes160 Congenital Splenic Abnormalities164 Extramedullary Hematopoiesis166 Gamna-Gandy Bodies168 Hemophagocytic Lymphohistiocytosis174 Immune Thrombocytopenic Purpura178 Niemann-Pick DiseaseMeenakshi A. Nandedkar, MD and Nadine Aguilera, MD184 Gaucher Disease188 Sea-Blue (Ceroid) Histiocytosis192 Gangliosidosis Lysosomal Disorder194 Therapy Effect on Spleen202 Traumatic and Nontraumatic Splenic InjuriesSECTION 3: NEOPLASTIC SPLENIC DISORDERSBENIGN MESENCHYMAL LESIONS208 Introduction to Vascular Lesions210 Hemangioma218 Lymphangioma222 Littoral Cell Angioma228 Inflammatory PseudotumorRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD236 Postchemotherapy Histiocyte-Rich Pseudotumor of SpleenRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD242 Splenic Hamartoma246 MyelolipomaMALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS 248 Angiosarcoma256 Hemangioendothelioma258 Kaposi Sarcoma260 Leiomyosarcoma266 Gastrointestinal Stromal Tumor272 Follicular Dendritic Cell Sarcoma280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma286 Langerhans Cell HistiocytosisGuanghua Wang, MD292 Histiocytic SarcomaLYMPHOMA300 Introduction to Lymphoma310 Splenic Marginal Zone Lymphoma318 Hairy Cell Leukemia326 Hairy Cell Leukemia Variant334 Lymphoplasmacytic Lymphoma342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma350 Follicular Lymphoma358 Mantle Cell Lymphoma366 Leukemic Nonnodal Mantle Cell Lymphoma370 Splenic Diffuse Red Pulp B-Cell Lymphoma376 B-Cell Prolymphocytic Leukemia378 Diffuse Large B-Cell Lymphoma384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma398 Burkitt Lymphoma406 Classic Hodgkin Lymphoma416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma426 Peripheral T-Cell Lymphoma, Unspecified432 Hepatosplenic T-Cell Lymphoma440 T-Cell Prolymphocytic Leukemia448 T-Cell Large Granular Lymphocytic Leukemia456 Aggressive NK-Cell Leukemia462 Transformation of Splenic DisordersLEUKEMIA466 Acute Myeloid Leukemia474 Lymphoblastic Leukemia/LymphomaCHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES480 Myeloproliferative Neoplasm Overview482 Chronic Myeloid Leukemia, BCR::ABL1 Positive488 Essential Thrombocythemia492 Polycythemia Vera496 Primary Myelofibrosis506 Mastocytosis514 Chronic Myelomonocytic LeukemiaPLASMA CELL-ASSOCIATED DISORDERS520 Amyloidosis526 Heavy Chain Disease530 Plasma Cell Myeloma/PlasmacytomaMETASTASIS534 Metastatic Tumors

Aaron Auerbach, MD, MPH, is the senior hematopathologist at the Joint Pathology Center in Silver Spring, Maryland, where he delivers expertise in both hematopathology and gastrointestinal pathology. He is the author of the prior and upcoming editions of Diagnostic Pathology: Molecular Oncology (2019 and 2023), and the sole author of Diagnostic Pathology: Spleen (2022).

"This book has grown since the first edition to maintain its standing as a comprehensive text (including 14 new chapters). Overall, this book provides all the essential knowledge on splenic pathology in one single resource. It is ideal for daily use as a reference but is also an excellent training resource for learners." -©Doody’s Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 5 Stars!

• SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEENNORMAL HISTOLOGY4 Introduction to SpleenMohammad A. Vasef, MD and Jeremy C. Wallentine, MD12 Imaging of Splenic DisordersMohammad A. Vasef, MD18 Handling, Processing, and Gross Pathology of Spleen26 Fine-Needle Aspiration and Core Biopsy of Spleen32 Immunohistochemistry of SpleenAaron Auerbach, MD, MPH40 Flow CytometryNadine Aguilera, MD46 Molecular TechniquesSECTION 2: NONNEOPLASTIC SPLENIC DISORDERSLYMPHOID HYPERPLASIA54 Florid Follicular HyperplasiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH56 Autoimmune Disease62 HIV in Spleen68 Castleman Disease70 Marginal Zone HyperplasiaGRANULOMATOUS LESIONS/DISORDERS72 LipogranulomasJeffrey Vos, MD78 SarcoidosisEllina Hall, DO and Aaron Auerbach, MD, MPH82 Chronic Granulomatous DiseaseINFECTIONS86 MycobacteriosisNadine Aguilera, MD 90 Selected Bacterial InfectionsAaron Auerbach, MD, MPH 94 Candidiasis96 Histoplasmosis98 Cryptococcosis100 Coccidioidomycosis104 Pneumocystosis108 Infectious Mononucleosis112 Cytomegalovirus Infection114 Herpes Simplex Virus InfectionAaron Auerbach, MD, MPH and Nadine Aguilera, MD116 Echinococcosis120 MalariaNONINFECTIOUS CYSTS122 Epithelial Cyst124 False CystNONNEOPLASTIC VASCULAR PROCESSES126 Chronic Passive Congestion128 Infarct136 Peliosis138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MDRED CELL DISORDERS144 Sickle Cell DiseaseAaron Auerbach, MD, MPH and Ellina Hall, DO146 ThalassemiaNadine Aguilera, MD and Aaron Auerbach, MD, MPH150 Hereditary Spherocytosis152 Thrombotic Thrombocytopenic PurpuraMISCELLANEOUS LESIONS/DISORDERS158 Heterotaxy Syndromes160 Congenital Splenic Abnormalities164 Extramedullary Hematopoiesis166 Gamna-Gandy Bodies168 Hemophagocytic Lymphohistiocytosis174 Immune Thrombocytopenic Purpura178 Niemann-Pick DiseaseMeenakshi A. Nandedkar, MD and Nadine Aguilera, MD184 Gaucher Disease188 Sea-Blue (Ceroid) Histiocytosis192 Gangliosidosis Lysosomal Disorder194 Therapy Effect on Spleen202 Traumatic and Nontraumatic Splenic InjuriesSECTION 3: NEOPLASTIC SPLENIC DISORDERSBENIGN MESENCHYMAL LESIONS208 Introduction to Vascular Lesions210 Hemangioma218 Lymphangioma222 Littoral Cell Angioma228 Inflammatory PseudotumorRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD236 Postchemotherapy Histiocyte-Rich Pseudotumor of SpleenRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD242 Splenic Hamartoma246 MyelolipomaMALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS 248 Angiosarcoma256 Hemangioendothelioma258 Kaposi Sarcoma260 Leiomyosarcoma266 Gastrointestinal Stromal Tumor272 Follicular Dendritic Cell Sarcoma280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma286 Langerhans Cell HistiocytosisGuanghua Wang, MD292 Histiocytic SarcomaLYMPHOMA300 Introduction to Lymphoma310 Splenic Marginal Zone Lymphoma318 Hairy Cell Leukemia326 Hairy Cell Leukemia Variant334 Lymphoplasmacytic Lymphoma342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma350 Follicular Lymphoma358 Mantle Cell Lymphoma366 Leukemic Nonnodal Mantle Cell Lymphoma370 Splenic Diffuse Red Pulp B-Cell Lymphoma376 B-Cell Prolymphocytic Leukemia378 Diffuse Large B-Cell Lymphoma384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma398 Burkitt Lymphoma406 Classic Hodgkin Lymphoma416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma426 Peripheral T-Cell Lymphoma, Unspecified432 Hepatosplenic T-Cell Lymphoma440 T-Cell Prolymphocytic Leukemia448 T-Cell Large Granular Lymphocytic Leukemia456 Aggressive NK-Cell Leukemia462 Transformation of Splenic DisordersLEUKEMIA466 Acute Myeloid Leukemia474 Lymphoblastic Leukemia/LymphomaCHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES480 Myeloproliferative Neoplasm Overview482 Chronic Myeloid Leukemia, BCR::ABL1 Positive488 Essential Thrombocythemia492 Polycythemia Vera496 Primary Myelofibrosis506 Mastocytosis514 Chronic Myelomonocytic LeukemiaPLASMA CELL-ASSOCIATED DISORDERS520 Amyloidosis526 Heavy Chain Disease530 Plasma Cell Myeloma/PlasmacytomaMETASTASIS534 Metastatic Tumors

Aaron Auerbach, MD, MPH, is the senior hematopathologist at the Joint Pathology Center in Silver Spring, Maryland, where he delivers expertise in both hematopathology and gastrointestinal pathology. He is the author of the prior and upcoming editions of Diagnostic Pathology: Molecular Oncology (2019 and 2023), and the sole author of Diagnostic Pathology: Spleen (2022).

"This book has grown since the first edition to maintain its standing as a comprehensive text (including 14 new chapters). Overall, this book provides all the essential knowledge on splenic pathology in one single resource. It is ideal for daily use as a reference but is also an excellent training resource for learners." -©Doody’s Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 5 Stars!

• SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEENNORMAL HISTOLOGY4 Introduction to SpleenMohammad A. Vasef, MD and Jeremy C. Wallentine, MD12 Imaging of Splenic DisordersMohammad A. Vasef, MD18 Handling, Processing, and Gross Pathology of Spleen26 Fine-Needle Aspiration and Core Biopsy of Spleen32 Immunohistochemistry of SpleenAaron Auerbach, MD, MPH40 Flow CytometryNadine Aguilera, MD46 Molecular TechniquesSECTION 2: NONNEOPLASTIC SPLENIC DISORDERSLYMPHOID HYPERPLASIA54 Florid Follicular HyperplasiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH56 Autoimmune Disease62 HIV in Spleen68 Castleman Disease70 Marginal Zone HyperplasiaGRANULOMATOUS LESIONS/DISORDERS72 LipogranulomasJeffrey Vos, MD78 SarcoidosisEllina Hall, DO and Aaron Auerbach, MD, MPH82 Chronic Granulomatous DiseaseINFECTIONS86 MycobacteriosisNadine Aguilera, MD 90 Selected Bacterial InfectionsAaron Auerbach, MD, MPH 94 Candidiasis96 Histoplasmosis98 Cryptococcosis100 Coccidioidomycosis104 Pneumocystosis108 Infectious Mononucleosis112 Cytomegalovirus Infection114 Herpes Simplex Virus InfectionAaron Auerbach, MD, MPH and Nadine Aguilera, MD116 Echinococcosis120 MalariaNONINFECTIOUS CYSTS122 Epithelial Cyst124 False CystNONNEOPLASTIC VASCULAR PROCESSES126 Chronic Passive Congestion128 Infarct136 Peliosis138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MDRED CELL DISORDERS144 Sickle Cell DiseaseAaron Auerbach, MD, MPH and Ellina Hall, DO146 ThalassemiaNadine Aguilera, MD and Aaron Auerbach, MD, MPH150 Hereditary Spherocytosis152 Thrombotic Thrombocytopenic PurpuraMISCELLANEOUS LESIONS/DISORDERS158 Heterotaxy Syndromes160 Congenital Splenic Abnormalities164 Extramedullary Hematopoiesis166 Gamna-Gandy Bodies168 Hemophagocytic Lymphohistiocytosis174 Immune Thrombocytopenic Purpura178 Niemann-Pick DiseaseMeenakshi A. Nandedkar, MD and Nadine Aguilera, MD184 Gaucher Disease188 Sea-Blue (Ceroid) Histiocytosis192 Gangliosidosis Lysosomal Disorder194 Therapy Effect on Spleen202 Traumatic and Nontraumatic Splenic InjuriesSECTION 3: NEOPLASTIC SPLENIC DISORDERSBENIGN MESENCHYMAL LESIONS208 Introduction to Vascular Lesions210 Hemangioma218 Lymphangioma222 Littoral Cell Angioma228 Inflammatory PseudotumorRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD236 Postchemotherapy Histiocyte-Rich Pseudotumor of SpleenRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD242 Splenic Hamartoma246 MyelolipomaMALIGNANT OR POTENTIALLY MALIGNANT MESENCHYMAL LESIONS 248 Angiosarcoma256 Hemangioendothelioma258 Kaposi Sarcoma260 Leiomyosarcoma266 Gastrointestinal Stromal Tumor272 Follicular Dendritic Cell Sarcoma280 Inflammatory Pseudotumor-Like Follicular Dendritic Cell Sarcoma286 Langerhans Cell HistiocytosisGuanghua Wang, MD292 Histiocytic SarcomaLYMPHOMA300 Introduction to Lymphoma310 Splenic Marginal Zone Lymphoma318 Hairy Cell Leukemia326 Hairy Cell Leukemia Variant334 Lymphoplasmacytic Lymphoma342 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma350 Follicular Lymphoma358 Mantle Cell Lymphoma366 Leukemic Nonnodal Mantle Cell Lymphoma370 Splenic Diffuse Red Pulp B-Cell Lymphoma376 B-Cell Prolymphocytic Leukemia378 Diffuse Large B-Cell Lymphoma384 Fibrin-Associated Large B-Cell Lymphoma in Splenic False Cyst390 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma398 Burkitt Lymphoma406 Classic Hodgkin Lymphoma416 Nodular Lymphocyte-Predominant Hodgkin Lymphoma426 Peripheral T-Cell Lymphoma, Unspecified432 Hepatosplenic T-Cell Lymphoma440 T-Cell Prolymphocytic Leukemia448 T-Cell Large Granular Lymphocytic Leukemia456 Aggressive NK-Cell Leukemia462 Transformation of Splenic DisordersLEUKEMIA466 Acute Myeloid Leukemia474 Lymphoblastic Leukemia/LymphomaCHRONIC MYELOPROLIFERATIVE NEOPLASMS/MYELODYSPLASTIC SYNDROMES480 Myeloproliferative Neoplasm Overview482 Chronic Myeloid Leukemia, BCR::ABL1 Positive488 Essential Thrombocythemia492 Polycythemia Vera496 Primary Myelofibrosis506 Mastocytosis514 Chronic Myelomonocytic LeukemiaPLASMA CELL-ASSOCIATED DISORDERS520 Amyloidosis526 Heavy Chain Disease530 Plasma Cell Myeloma/PlasmacytomaMETASTASIS534 Metastatic Tumors