Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas

L. Jeffrey Medeiros MD is Professor and Chair at the Department of Hematopathology of the University of Texas MD Anderson Cancer Center in Houston, Texas. His research interests include the diagnosis of lymphomas, including the use of histologic, imunnophenotypic, and molecular methods for diagnosis and prognosis, and most recent research efforts have focused on diffuse aggressive B-cell lymphomas. Dr. Medeiros is the returning co-lead author of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas. Roberto N. Miranda, MD is a Professor at the Department of Hematopathology at the University of Texas MD Anderson Cancer Center in Houston, Texas. His research interests include T-cell lymphomas and he has developed an expertise in breast implant-associated anaplastic large cell lymphoma, a topic on which he has several landmark publications and book chapters, and on which he has lectured nationally and internationally. Dr. Miranda is the returning co-lead author of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas.

"This book is part of the Diagnostic Pathology Series, covering benign and malignant lesions of lymph nodes, as well as extranodal lymphomas. This third edition has been updated from the previous version, published in 2017, according to the most recent fifth edition of the WHO Classification of Hematolymphoid Tumors." ©Doody's Review Service, 2023 Anamarija Perry, MD (University of Michigan Medical School) Doody's Score: 5 Stars!

• SECTION 1: REACTIVE NONSPECIFIC CHANGES4 Reactive Follicular HyperplasiaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD10 Reactive Paracortical HyperplasiaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MDSECTION 2: INFECTIOUS CAUSES OF LYMPHADENITIS20 Chronic Granulomatous LymphadenitisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD28 Suppurative LymphadenitisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD32 Mycobacterium tuberculosis LymphadenitisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD40 Atypical Mycobacterial LymphadenitisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD48 Mycobacterial Spindle Cell PseudotumorL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD52 Cat-Scratch DiseaseRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD58 Bacillary AngiomatosisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD64 Lymphogranuloma Venereum LymphadenitisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD68 Whipple DiseaseL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD72 Syphilitic LymphadenitisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD78 Infectious MononucleosisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD84 Histoplasma LymphadenitisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD90 Cryptococcus LymphadenitisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD94 Toxoplasma LymphadenitisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD100 Coccidioides LymphadenitisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD106 Herpes Simplex LymphadenitisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD112 Cytomegalovirus LymphadenitisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD120 Human Immunodeficiency Virus LymphadenitisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MDSECTION 3: REACTIVE LYMPHADENOPATHIES132 Inflammatory Pseudotumor of Lymph NodeL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD140 Progressive Transformation of Germinal CentersL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD146 Kikuchi-Fujimoto DiseaseL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD156 Rosai-Dorfman DiseaseL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD166 Kimura DiseaseRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD174 Unicentric Hyaline-Vascular Variant Castleman DiseaseL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD182 Unicentric Mixed/Plasmacytic Variant Castleman DiseaseL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD188 Multicentric Castleman Disease, IdiopathicL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD196 Multicentric Castleman Disease, HHV8 AssociatedL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD204 Rheumatoid Arthritis-Related LymphadenopathyL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD212 Sarcoid LymphadenopathyRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD218 Dermatopathic LymphadenopathyRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD224 Hemophagocytic LymphohistiocytosisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD234 Lymphadenopathy Associated With Joint ProsthesesRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD240 Lipid-Associated LymphadenopathyRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD244 Lymphadenopathy Secondary to Drug-Induced Hypersensitivity SyndromeL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD254 IgG4-Related DiseaseRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD264 Systemic Lupus ErythematosusRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD270 Sinus HistiocytosisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MDSECTION 4: HODGKIN LYMPHOMAS278 Nodular Lymphocyte-Predominant Hodgkin LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD290 Nodular Lymphocyte-Predominant Hodgkin Lymphoma: TablesL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD292 Lymphocyte-Rich Classic Hodgkin LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD300 Nodular Sclerosis Hodgkin LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD310 Mixed Cellularity Hodgkin LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD316 Lymphocyte-Depleted Hodgkin LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MDSECTION 5: LEUKEMIA/LYMPHOMAS OF IMMATURE B- OR T-CELL LINEAGE324 B-Lymphoblastic Leukemia/LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD334 T-Lymphoblastic Lymphoma/LeukemiaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MDSECTION 6: NODAL B-CELL LYMPHOMAS346 Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD356 Richter TransformationRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD364 Lymphoplasmacytic Lymphoma and Waldenström MacroglobulinemiaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD374 Nodal Marginal Zone LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD380 Nodal Follicular LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD392 Pediatric-Type Follicular LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD396 Mantle Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD404 Mantle Cell Lymphoma, Blastoid and Pleomorphic VariantsL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD412 Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD422 T-Cell/Histiocyte-Rich Large B-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD428 ALK(+) Large B-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD434 EBV(+) Diffuse Large B-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD442 HHV8(+) Diffuse Large B-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD450 Burkitt LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD460 High-Grade B-Cell LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD468 Mediastinal Gray Zone LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MDSECTION 7: EXTRANODAL B-CELL LYMPHOMAS480 Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD494 Extranodal Follicular LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD506 Primary Cutaneous Follicle Center LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD516 Primary Mediastinal (Thymic) Large B-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD526 Primary Diffuse Large B-Cell Lymphoma of Central Nervous SystemL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD536 Pyothorax-Associated LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD542 Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg TypeRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD550 Plasmablastic LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD560 Primary Effusion Lymphoma and Solid Variant of Primary Effusion LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD570 Lymphomatoid GranulomatosisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD580 Intravascular Large B-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD586 PlasmacytomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD594 EBV-Positive Large B-Cell Lymphoma Associated With Breast ImplantsL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD600 Primary Diffuse Large B-Cell Lymphoma of TestisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD608 Splenic Marginal Zone LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD616 Hairy Cell LeukemiaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD624 Hairy Cell Leukemia VariantRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD632 Splenic Diffuse Red Pulp B-Cell LymphomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD638 Diffuse Large B-Cell Lymphoma Arising in the SpleenL. Jeffrey Medeiros, MD and Roberto N. Miranda, MDSECTION 8: NODAL T-CELL LYMPHOMAS646 Peripheral T-Cell Lymphoma, Not Otherwise SpecifiedL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD656 Angioimmunoblastic T-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD666 Adult T-Cell Leukemia/Lymphoma, HTLV-1(+)L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD676 ALK(+) Anaplastic Large Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD684 ALK(-) Anaplastic Large Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MDSECTION 9: EXTRANODAL NK-/T-CELL LYMPHOMAS694 Breast Implant-Associated Anaplastic Large Cell LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD706 Extranodal NK-/T-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD716 Hepatosplenic T-Cell LymphomaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD726 Enteropathy-Associated T-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD734 Monomorphic Epitheliotropic Intestinal T-Cell LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD742 Indolent T-Cell Lymphoma of the Gastrointestinal TractRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD748 Subcutaneous Panniculitis-Like T-Cell LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD756 T-Cell Prolymphocytic Leukemia Involving LymphL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD766 Primary Cutaneous ?/? T-Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD774 EBV(+) T- and NK-Cell Lymphoid Proliferations and Lymphomas of ChildhoodRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD784 Mycosis FungoidesL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD798 Sézary SyndromeL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD810 Primary Cutaneous Anaplastic Large Cell LymphomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD818 Lymphomatoid PapulosisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD826 Primary Cutaneous Acral CD8(+) Lymphoproliferative DisorderRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD832 Primary Cutaneous CD8(+) AggressiveEpidermotropic Cytotoxic T-Cell LymphomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD840 Primary Cutaneous CD4(+) Small/Medium T-Cell Lymphoproliferative DisorderL. Jeffrey Medeiros, MD and Roberto N. Miranda, MDSECTION 10: IMMUNODEFICIENCYASSOCIATED LYMPHOPROLIFERATIONS846 Overview of Primary Immunodeficiency-Associated Lymphoproliferative DisordersL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD852 Autoimmune Lymphoproliferative SyndromeL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD864 Immunomodulating Agent-Associated Lymphoproliferative DisordersL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD872 Posttransplant Lymphoproliferative Disorders, Nondestructive Lesions and PolymorphicL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD882 Posttransplant Lymphoproliferative Disorder, MonomorphicL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD892 EBV(+) Mucocutaneous UlcerL. Jeffrey Medeiros, MD and Roberto N. Miranda, MDSECTION 11: GRANULOCYTIC/HISTIOCYTIC TUMORS898 Myeloid SarcomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD906 Blastic Plasmacytoid Dendritic Cell NeoplasmL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD914 Blastic T/Myeloid Neoplasm With Rearrangements of FGFR1Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD924 Cutaneous MastocytosisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD928 Systemic MastocytosisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD940 Histiocytic SarcomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD950 Follicular Dendritic Cell SarcomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD958 Interdigitating Dendritic Cell SarcomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD964 Langerhans Cell HistiocytosisRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD976 Langerhans Cell SarcomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD984 Erdheim-Chester DiseaseL. Jeffrey Medeiros, MD and Roberto N. Miranda, MDSECTION 12: NONHEMATOPOIETIC PROLIFERATIONS IN LYMPH NODE990 Epithelial Inclusions in Lymph NodeRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD996 Nevus Cell Inclusions in Lymph NodeRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD1000 Vascular Transformation of Lymph Node SinusesL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD1004 Angiomyomatous HamartomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD1008 Palisaded MyofibroblastomaL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD1012 Metastatic Kaposi SarcomaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD