Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas

L. Jeffrey Medeiros MD is Professor and Chair at the Department of Hematopathology of the University of Texas MD Anderson Cancer Center in Houston, Texas. His research interests include the diagnosis of lymphomas, including the use of histologic, imunnophenotypic, and molecular methods for diagnosis and prognosis, and most recent research efforts have focused on diffuse aggressive B-cell lymphomas. Dr. Medeiros is the returning co-lead author of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas. Roberto N. Miranda, MD is a Professor at the Department of Hematopathology at the University of Texas MD Anderson Cancer Center in Houston, Texas. His research interests include T-cell lymphomas and he has developed an expertise in breast implant-associated anaplastic large cell lymphoma, a topic on which he has several landmark publications and book chapters, and on which he has lectured nationally and internationally. Dr. Miranda is the returning co-lead author of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas.

"This book is part of the Diagnostic Pathology Series, covering benign and malignant lesions of lymph nodes, as well as extranodal lymphomas. This third edition has been updated from the previous version, published in 2017, according to the most recent fifth edition of the WHO Classification of Hematolymphoid Tumors." -©Doody’s Review Service, 2023 Anamarija Perry, MD (University of Michigan Medical School) Doody's Score: 5 Stars!

• SECTION 1: REACTIVE NONSPECIFIC CHANGES4 Reactive Follicular HyperplasiaRoberto N. Miranda, MD and L. Jeffrey Medeiros, MD10 Reactive Paracortical HyperplasiaSECTION 2: INFECTIOUS CAUSES OF LYMPHADENITIS20 Chronic Granulomatous LymphadenitisL. Jeffrey Medeiros, MD and Roberto N. Miranda, MD28 Suppurative Lymphadenitis32 Mycobacterium tuberculosis Lymphadenitis40 Atypical Mycobacterial Lymphadenitis48 Mycobacterial Spindle Cell Pseudotumor52 Cat-Scratch Disease58 Bacillary Angiomatosis64 Lymphogranuloma Venereum Lymphadenitis68 Whipple Disease72 Syphilitic Lymphadenitis78 Infectious Mononucleosis84 Histoplasma Lymphadenitis90 Cryptococcus Lymphadenitis94 Toxoplasma Lymphadenitis100 Coccidioides Lymphadenitis106 Herpes Simplex Lymphadenitis112 Cytomegalovirus Lymphadenitis120 Human Immunodeficiency Virus LymphadenitisSECTION 3: REACTIVE LYMPHADENOPATHIES132 Inflammatory Pseudotumor of Lymph Node140 Progressive Transformation of Germinal Centers146 Kikuchi-Fujimoto Disease156 Rosai-Dorfman Disease166 Kimura Disease174 Unicentric Hyaline-Vascular Variant Castleman Disease182 Unicentric Mixed/Plasmacytic Variant Castleman Disease188 Multicentric Castleman Disease, Idiopathic196 Multicentric Castleman Disease, HHV8 Associated204 Rheumatoid Arthritis-Related Lymphadenopathy212 Sarcoid Lymphadenopathy218 Dermatopathic Lymphadenopathy224 Hemophagocytic Lymphohistiocytosis234 Lymphadenopathy Associated With Joint Prostheses240 Lipid-Associated Lymphadenopathy244 Lymphadenopathy Secondary to Drug-Induced Hypersensitivity Syndrome254 IgG4-Related Disease264 Systemic Lupus Erythematosus270 Sinus HistiocytosisSECTION 4: HODGKIN LYMPHOMAS278 Nodular Lymphocyte-Predominant Hodgkin Lymphoma290 Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Tables292 Lymphocyte-Rich Classic Hodgkin Lymphoma300 Nodular Sclerosis Hodgkin Lymphoma310 Mixed Cellularity Hodgkin Lymphoma316 Lymphocyte-Depleted Hodgkin LymphomaSECTION 5: LEUKEMIA/LYMPHOMAS OF IMMATURE B- OR T-CELL LINEAGE324 B-Lymphoblastic Leukemia/Lymphoma334 T-Lymphoblastic Lymphoma/LeukemiaSECTION 6: NODAL B-CELL LYMPHOMAS346 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma356 Richter Transformation364 Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia374 Nodal Marginal Zone Lymphoma380 Nodal Follicular Lymphoma392 Pediatric-Type Follicular Lymphoma396 Mantle Cell Lymphoma404 Mantle Cell Lymphoma, Blastoid and Pleomorphic Variants412 Diffuse Large B-Cell Lymphoma, Not Otherwise Specified422 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma428 ALK(+) Large B-Cell Lymphoma434 EBV(+) Diffuse Large B-Cell Lymphoma442 HHV8(+) Diffuse Large B-Cell Lymphoma450 Burkitt Lymphoma460 High-Grade B-Cell Lymphoma468 Mediastinal Gray Zone LymphomaSECTION 7: EXTRANODAL B-CELL LYMPHOMAS480 Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)494 Extranodal Follicular Lymphoma506 Primary Cutaneous Follicle Center Lymphoma516 Primary Mediastinal (Thymic) Large B-Cell Lymphoma526 Primary Diffuse Large B-Cell Lymphoma of Central Nervous System536 Pyothorax-Associated Lymphoma542 Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type550 Plasmablastic Lymphoma560 Primary Effusion Lymphoma and Solid Variant of Primary Effusion Lymphoma570 Lymphomatoid Granulomatosis580 Intravascular Large B-Cell Lymphoma586 Plasmacytoma594 EBV-Positive Large B-Cell Lymphoma Associated With Breast Implants600 Primary Diffuse Large B-Cell Lymphoma of Testis608 Splenic Marginal Zone Lymphoma616 Hairy Cell LeukemiaRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD624 Hairy Cell Leukemia Variant632 Splenic Diffuse Red Pulp B-Cell Lymphoma638 Diffuse Large B-Cell Lymphoma Arising in the SpleenSECTION 8: NODAL T-CELL LYMPHOMAS646 Peripheral T-Cell Lymphoma, Not Otherwise Specified656 Angioimmunoblastic T-Cell Lymphoma666 Adult T-Cell Leukemia/Lymphoma, HTLV-1(+)676 ALK(+) Anaplastic Large Cell Lymphoma684 ALK(-) Anaplastic Large Cell LymphomaSECTION 9: EXTRANODAL NK-/T-CELL LYMPHOMAS694 Breast Implant-Associated Anaplastic Large Cell Lymphoma706 Extranodal NK-/T-Cell Lymphoma716 Hepatosplenic T-Cell Lymphoma726 Enteropathy-Associated T-Cell Lymphoma734 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma742 Indolent T-Cell Lymphoma of the Gastrointestinal Tract748 Subcutaneous Panniculitis-Like T-Cell Lymphoma756 T-Cell Prolymphocytic Leukemia Involving Lymph766 Primary Cutaneous ?/? T-Cell Lymphoma774 EBV(+) T- and NK-Cell Lymphoid Proliferations and Lymphomas of Childhood784 Mycosis Fungoides798 Sézary Syndrome810 Primary Cutaneous Anaplastic Large Cell Lymphoma818 Lymphomatoid Papulosis826 Primary Cutaneous Acral CD8(+) Lymphoproliferative Disorder832 Primary Cutaneous CD8(+) AggressiveEpidermotropic Cytotoxic T-Cell Lymphoma840 Primary Cutaneous CD4(+) Small/Medium T-Cell Lymphoproliferative DisorderSECTION 10: IMMUNODEFICIENCYASSOCIATED LYMPHOPROLIFERATIONS846 Overview of Primary Immunodeficiency-Associated Lymphoproliferative Disorders852 Autoimmune Lymphoproliferative Syndrome864 Immunomodulating Agent-Associated Lymphoproliferative Disorders872 Posttransplant Lymphoproliferative Disorders, Nondestructive Lesions and Polymorphic882 Posttransplant Lymphoproliferative Disorder, Monomorphic892 EBV(+) Mucocutaneous UlcerSECTION 11: GRANULOCYTIC/HISTIOCYTIC TUMORS898 Myeloid Sarcoma906 Blastic Plasmacytoid Dendritic Cell Neoplasm914 Blastic T/Myeloid Neoplasm With Rearrangements of FGFR1924 Cutaneous Mastocytosis928 Systemic Mastocytosis940 Histiocytic Sarcoma950 Follicular Dendritic Cell Sarcoma958 Interdigitating Dendritic Cell Sarcoma964 Langerhans Cell Histiocytosis976 Langerhans Cell Sarcoma984 Erdheim-Chester DiseaseSECTION 12: NONHEMATOPOIETIC PROLIFERATIONS IN LYMPH NODE990 Epithelial Inclusions in Lymph Node996 Nevus Cell Inclusions in Lymph Node1000 Vascular Transformation of Lymph Node Sinuses1004 Angiomyomatous Hamartoma1008 Palisaded Myofibroblastoma1012 Metastatic Kaposi Sarcoma