Dr. Sanjay Kakar, MD, is Professor of Pathology and Chief of Gastrointestinal and Hepatobiliary Pathology Service at the University of California, San Francisco in San Francisco, California Maria Westerhoff, MD, is Professor of Pathology in the Gastrointestinal and Hepatobiliary Section, as well as Assistant Chair of Well-Being and Culture with the Department of Pathology at the University of Michigan in Ann Arbor, Michigan

Review of the previous edition: "The lists of differentials are incredibly helpful during diagnostic workup and to educate readers about similar entities that should be considered. The diagnostic checklists are especially helpful and emphasize important pathologic features and interpretation pearls. I strongly recommend this book to everyone interested in learning and reviewing hepatobiliary and pancreatic pathology." --©Doody’s Review Service, 2022, Jiayun Fang, MD (University of Michigan Medical School) Doody's Score: 5 Stars!

• PART I: LIVERSECTION 1: INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERSGlycogen Storage Disease, HepaticTyrosinemiaNiemann-Pick DiseaseGaucher DiseaseNeonatal HemochromatosisPorphyrin Metabolism DisordersDubin-Johnson SyndromeGilbert DiseaseProgressive Familial Intrahepatic CholestasisCystic Fibrosis, HepaticHereditary HemochromatosisWilson DiseaseAlpha-1 Antitrypsin DeficiencyCongenital Hepatic FibrosisPolycystic Liver DiseaseCaroli DiseaseLysosomal Lipase Deficiency (Including Wolman Disease)SECTION 2: INFECTIOUS DISORDERSOverview of HepatitisAcute Viral HepatitisHepatitis BHepatitis CHepatitis EEpstein-Barr VirusCytomegalovirusHerpes Simplex VirusAdenovirusPyogenic AbscessSepsis in the LiverMycobacterium tuberculosisAtypical MycobacteriaCat-Scratch DiseaseCandidiasisHistoplasmosisCryptococcosisAmebiasisSchistosomiasisEchinococcosisSyphilisSECTION 3: CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERSMedical Liver Biopsy: Indications and Approach to DiagnosisAutoimmune HepatitisAutoimmune Hepatitis Diagnostic Criteria and Grading/Staging InformationPrimary Biliary CholangitisPrimary Sclerosing CholangitisIschemic CholangitisLarge Bile Duct ObstructionLiver Involvement in IgG4-Related DiseaseIdiopathic Adulthood DuctopeniaSECTION 4: PEDIATRIC CHOLESTATIC DISORDERSBiliary AtresiaNeonatal HepatitisSyndromic Paucity of Intrahepatic Bile Ducts (Alagille Syndrome)Nonsyndromic Paucity of Intrahepatic Bile DuctsSECTION 5: DRUG/TOXIN-RELATED HEPATITISDrug-Induced Acute HepatitisDrug-Induced Acute Hepatic FailureDrug-Induced Cholestatic Liver InjuryDrug-Induced Granulomatous HepatitisDrug-Induced Steatohepatitis/PhospholipidosisReye SyndromeDrug-Induced Cholangitis/DuctopeniaHepatic Stellate Cell HyperplasiaSECTION 6: STEATOTIC LIVER DISEASESAlcohol-Associated Liver DiseaseMetabolic Dysfunction-Associated SteatohepatitisGlycogenic HepatopathyFatty Liver of PregnancySECTION 7: VASCULAR DISORDERSPortal Venopathy/Portal Sinusoidal Vascular DisorderHepatic Venous Outflow ObstructionVenoocclusive DiseaseAmyloidosisIschemiaNodular Regenerative HyperplasiaSECTION 8: TRANSPLANTATION PATHOLOGYIschemia Reperfusion InjuryAntibody-Mediated RejectionT-Cell-Mediated Rejection (Acute Cellular Rejection)Chronic RejectionCentral Perivenulitis/Parenchymal RejectionHepatic Artery ThrombosisGraft-vs.-Host DiseaseSECTION 9: TUMORS OF THE LIVERApproach to Liver Biopsy for Mass LesionsHepatectomy Specimen HandlingHepatocellular AdenomaFocal Nodular HyperplasiaRegenerative and Dysplastic NodulesHepatocellular Carcinoma and VariantsFibrolamellar CarcinomaCombined Hepatocellular-CholangiocarcinomaHepatoblastomaBile Duct Adenomavon Meyenburg Complex (Biliary Microhamartoma)Mucinous Cystic Neoplasm, LiverIntrahepatic CholangiocarcinomaIntrahepatic Cholangiocarcinoma, Histologic SubtypesIntraductal Papillary Neoplasm of Bile DuctHemangiomaAngiomyolipomaHepatic Small Vessel Neoplasm/Anastamosing HemangiomaEpithelioid HemangioendotheliomaInfantile HemangiomaAngiosarcomaMesenchymal HamartomaEmbryonal SarcomaInflammatory PseudotumorSegmental Atrophy (Nodular Elastosis)Tumors Metastatic to LiverSECTION 10: MISCELLANEOUS HEPATIC DISORDERSLangerhans Cell HistiocytosisHemophagocytic LymphohistiocytosisLiver Involvement in Systemic Liver DiseasesPART II: PANCREAS AND BILIARY TRACTSECTION 1: DEVELOPMENTAL/CONGENITAL DISORDERSCongenital Pancreatic CystCystic Fibrosis, PancreaticNesidioblastosisCholedochal CystSECTION 2: INFLAMMATORY DISORDERS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREECholelithiasisAcute CholecystitisChronic CholecystitisXanthogranulomatous CholecystitisEosinophilic CholecystitisPolyarteritis Nodosa and Other VasculitidesParasitic InfectionSECTION 3: NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREASAcute PancreatitisChronic PancreatitisAutoimmune PancreatitisGroove PancreatitisInfectious PancreatitisPseudocystsDiabetes MellitusLymphoepithelial Cyst of the PancreasSECTION 4: TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREESpecimen Handling, GallbladderMass-Forming Intracholecystic NeoplasmCarcinoma of GallbladderCarcinoma of Extrahepatic Bile DuctsSquamous/Adenosquamous Carcinoma, GallbladderNeuroendocrine Neoplasms of GallbladderGranular Cell TumorEmbryonal RhabdomyosarcomaAdenomyomaNonneoplastic Polypoid Gallbladder LesionsSECTION 5: TUMORS OF THE PANCREASSpecimen Handling, WhipplePancreatic Intraepithelial NeoplasiaDuctal Adenocarcinoma, Including Histologic SubtypesUndifferentiated CarcinomaAdenosquamous Carcinoma, PancreasAcinar Cell CarcinomaSerous CystadenomaAcinar Cystic Transformation of the PancreasWell-Differentiated Neuroendocrine Tumor, PancreasPoorly Differentiated Neuroendocrine Carcinoma, PancreasGenomic Diagnosis of Intrahepatic Hepatobiliary TumorsRole of Genomics in Diagnosis of Pancreaticobiliary TumorsSimple Mucinous CystMucinous Cystic Neoplasm, PancreasIntraductal Papillary Mucinous NeoplasmIntraductal Oncocytic Papillary NeoplasmIntraductal Tubulopapillary NeoplasmSolid Pseudopapillary NeoplasmPancreatoblastomaDermoid CystSECTION 6: TUMORS OF THE AMPULLAAmpullary AdenomaAmpullary Adenocarcinoma and Histologic SubtypesWell-Differentiated Neuroendocrine Tumor, AmpullaComposite Gangliocytoma/Neuroma and Neuroendocrine Tumor/Gangliocytic Paraganglioma

Dr. Sanjay Kakar, MD, is Professor of Pathology and Chief of Gastrointestinal and Hepatobiliary Pathology Service at the University of California, San Francisco in San Francisco, California Maria Westerhoff, MD, is Professor of Pathology in the Gastrointestinal and Hepatobiliary Section, as well as Assistant Chair of Well-Being and Culture with the Department of Pathology at the University of Michigan in Ann Arbor, Michigan

Review of the previous edition: "The lists of differentials are incredibly helpful during diagnostic workup and to educate readers about similar entities that should be considered. The diagnostic checklists are especially helpful and emphasize important pathologic features and interpretation pearls. I strongly recommend this book to everyone interested in learning and reviewing hepatobiliary and pancreatic pathology." --©Doody’s Review Service, 2022, Jiayun Fang, MD (University of Michigan Medical School) Doody's Score: 5 Stars!

• PART I: LIVERSECTION 1: INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERSGlycogen Storage Disease, HepaticTyrosinemiaNiemann-Pick DiseaseGaucher DiseaseNeonatal HemochromatosisPorphyrin Metabolism DisordersDubin-Johnson SyndromeGilbert DiseaseProgressive Familial Intrahepatic CholestasisCystic Fibrosis, HepaticHereditary HemochromatosisWilson DiseaseAlpha-1 Antitrypsin DeficiencyCongenital Hepatic FibrosisPolycystic Liver DiseaseCaroli DiseaseLysosomal Lipase Deficiency (Including Wolman Disease)SECTION 2: INFECTIOUS DISORDERSOverview of HepatitisAcute Viral HepatitisHepatitis BHepatitis CHepatitis EEpstein-Barr VirusCytomegalovirusHerpes Simplex VirusAdenovirusPyogenic AbscessSepsis in the LiverMycobacterium tuberculosisAtypical MycobacteriaCat-Scratch DiseaseCandidiasisHistoplasmosisCryptococcosisAmebiasisSchistosomiasisEchinococcosisSyphilisSECTION 3: CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERSMedical Liver Biopsy: Indications and Approach to DiagnosisAutoimmune HepatitisAutoimmune Hepatitis Diagnostic Criteria and Grading/Staging InformationPrimary Biliary CholangitisPrimary Sclerosing CholangitisIschemic CholangitisLarge Bile Duct ObstructionLiver Involvement in IgG4-Related DiseaseIdiopathic Adulthood DuctopeniaSECTION 4: PEDIATRIC CHOLESTATIC DISORDERSBiliary AtresiaNeonatal HepatitisSyndromic Paucity of Intrahepatic Bile Ducts (Alagille Syndrome)Nonsyndromic Paucity of Intrahepatic Bile DuctsSECTION 5: DRUG/TOXIN-RELATED HEPATITISDrug-Induced Acute HepatitisDrug-Induced Acute Hepatic FailureDrug-Induced Cholestatic Liver InjuryDrug-Induced Granulomatous HepatitisDrug-Induced Steatohepatitis/PhospholipidosisReye SyndromeDrug-Induced Cholangitis/DuctopeniaHepatic Stellate Cell HyperplasiaSECTION 6: STEATOTIC LIVER DISEASESAlcohol-Associated Liver DiseaseMetabolic Dysfunction-Associated SteatohepatitisGlycogenic HepatopathyFatty Liver of PregnancySECTION 7: VASCULAR DISORDERSPortal Venopathy/Portal Sinusoidal Vascular DisorderHepatic Venous Outflow ObstructionVenoocclusive DiseaseAmyloidosisIschemiaNodular Regenerative HyperplasiaSECTION 8: TRANSPLANTATION PATHOLOGYIschemia Reperfusion InjuryAntibody-Mediated RejectionT-Cell-Mediated Rejection (Acute Cellular Rejection)Chronic RejectionCentral Perivenulitis/Parenchymal RejectionHepatic Artery ThrombosisGraft-vs.-Host DiseaseSECTION 9: TUMORS OF THE LIVERApproach to Liver Biopsy for Mass LesionsHepatectomy Specimen HandlingHepatocellular AdenomaFocal Nodular HyperplasiaRegenerative and Dysplastic NodulesHepatocellular Carcinoma and VariantsFibrolamellar CarcinomaCombined Hepatocellular-CholangiocarcinomaHepatoblastomaBile Duct Adenomavon Meyenburg Complex (Biliary Microhamartoma)Mucinous Cystic Neoplasm, LiverIntrahepatic CholangiocarcinomaIntrahepatic Cholangiocarcinoma, Histologic SubtypesIntraductal Papillary Neoplasm of Bile DuctHemangiomaAngiomyolipomaHepatic Small Vessel Neoplasm/Anastamosing HemangiomaEpithelioid HemangioendotheliomaInfantile HemangiomaAngiosarcomaMesenchymal HamartomaEmbryonal SarcomaInflammatory PseudotumorSegmental Atrophy (Nodular Elastosis)Tumors Metastatic to LiverSECTION 10: MISCELLANEOUS HEPATIC DISORDERSLangerhans Cell HistiocytosisHemophagocytic LymphohistiocytosisLiver Involvement in Systemic Liver DiseasesPART II: PANCREAS AND BILIARY TRACTSECTION 1: DEVELOPMENTAL/CONGENITAL DISORDERSCongenital Pancreatic CystCystic Fibrosis, PancreaticNesidioblastosisCholedochal CystSECTION 2: INFLAMMATORY DISORDERS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREECholelithiasisAcute CholecystitisChronic CholecystitisXanthogranulomatous CholecystitisEosinophilic CholecystitisPolyarteritis Nodosa and Other VasculitidesParasitic InfectionSECTION 3: NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREASAcute PancreatitisChronic PancreatitisAutoimmune PancreatitisGroove PancreatitisInfectious PancreatitisPseudocystsDiabetes MellitusLymphoepithelial Cyst of the PancreasSECTION 4: TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREESpecimen Handling, GallbladderMass-Forming Intracholecystic NeoplasmCarcinoma of GallbladderCarcinoma of Extrahepatic Bile DuctsSquamous/Adenosquamous Carcinoma, GallbladderNeuroendocrine Neoplasms of GallbladderGranular Cell TumorEmbryonal RhabdomyosarcomaAdenomyomaNonneoplastic Polypoid Gallbladder LesionsSECTION 5: TUMORS OF THE PANCREASSpecimen Handling, WhipplePancreatic Intraepithelial NeoplasiaDuctal Adenocarcinoma, Including Histologic SubtypesUndifferentiated CarcinomaAdenosquamous Carcinoma, PancreasAcinar Cell CarcinomaSerous CystadenomaAcinar Cystic Transformation of the PancreasWell-Differentiated Neuroendocrine Tumor, PancreasPoorly Differentiated Neuroendocrine Carcinoma, PancreasGenomic Diagnosis of Intrahepatic Hepatobiliary TumorsRole of Genomics in Diagnosis of Pancreaticobiliary TumorsSimple Mucinous CystMucinous Cystic Neoplasm, PancreasIntraductal Papillary Mucinous NeoplasmIntraductal Oncocytic Papillary NeoplasmIntraductal Tubulopapillary NeoplasmSolid Pseudopapillary NeoplasmPancreatoblastomaDermoid CystSECTION 6: TUMORS OF THE AMPULLAAmpullary AdenomaAmpullary Adenocarcinoma and Histologic SubtypesWell-Differentiated Neuroendocrine Tumor, AmpullaComposite Gangliocytoma/Neuroma and Neuroendocrine Tumor/Gangliocytic Paraganglioma

Dr. Sanjay Kakar, MD, is Professor of Pathology and Chief of Gastrointestinal and Hepatobiliary Pathology Service at the University of California, San Francisco in San Francisco, California Maria Westerhoff, MD, is Professor of Pathology in the Gastrointestinal and Hepatobiliary Section, as well as Assistant Chair of Well-Being and Culture with the Department of Pathology at the University of Michigan in Ann Arbor, Michigan

Review of the previous edition: "The lists of differentials are incredibly helpful during diagnostic workup and to educate readers about similar entities that should be considered. The diagnostic checklists are especially helpful and emphasize important pathologic features and interpretation pearls. I strongly recommend this book to everyone interested in learning and reviewing hepatobiliary and pancreatic pathology." --©Doody’s Review Service, 2022, Jiayun Fang, MD (University of Michigan Medical School) Doody's Score: 5 Stars!

• PART I: LIVERSECTION 1: INHERITED, METABOLIC, AND DEVELOPMENTAL DISORDERSGlycogen Storage Disease, HepaticTyrosinemiaNiemann-Pick DiseaseGaucher DiseaseNeonatal HemochromatosisPorphyrin Metabolism DisordersDubin-Johnson SyndromeGilbert DiseaseProgressive Familial Intrahepatic CholestasisCystic Fibrosis, HepaticHereditary HemochromatosisWilson DiseaseAlpha-1 Antitrypsin DeficiencyCongenital Hepatic FibrosisPolycystic Liver DiseaseCaroli DiseaseLysosomal Lipase Deficiency (Including Wolman Disease)SECTION 2: INFECTIOUS DISORDERSOverview of HepatitisAcute Viral HepatitisHepatitis BHepatitis CHepatitis EEpstein-Barr VirusCytomegalovirusHerpes Simplex VirusAdenovirusPyogenic AbscessSepsis in the LiverMycobacterium tuberculosisAtypical MycobacteriaCat-Scratch DiseaseCandidiasisHistoplasmosisCryptococcosisAmebiasisSchistosomiasisEchinococcosisSyphilisSECTION 3: CHRONIC CHOLESTATIC AND AUTOIMMUNE DISORDERSMedical Liver Biopsy: Indications and Approach to DiagnosisAutoimmune HepatitisAutoimmune Hepatitis Diagnostic Criteria and Grading/Staging InformationPrimary Biliary CholangitisPrimary Sclerosing CholangitisIschemic CholangitisLarge Bile Duct ObstructionLiver Involvement in IgG4-Related DiseaseIdiopathic Adulthood DuctopeniaSECTION 4: PEDIATRIC CHOLESTATIC DISORDERSBiliary AtresiaNeonatal HepatitisSyndromic Paucity of Intrahepatic Bile Ducts (Alagille Syndrome)Nonsyndromic Paucity of Intrahepatic Bile DuctsSECTION 5: DRUG/TOXIN-RELATED HEPATITISDrug-Induced Acute HepatitisDrug-Induced Acute Hepatic FailureDrug-Induced Cholestatic Liver InjuryDrug-Induced Granulomatous HepatitisDrug-Induced Steatohepatitis/PhospholipidosisReye SyndromeDrug-Induced Cholangitis/DuctopeniaHepatic Stellate Cell HyperplasiaSECTION 6: STEATOTIC LIVER DISEASESAlcohol-Associated Liver DiseaseMetabolic Dysfunction-Associated SteatohepatitisGlycogenic HepatopathyFatty Liver of PregnancySECTION 7: VASCULAR DISORDERSPortal Venopathy/Portal Sinusoidal Vascular DisorderHepatic Venous Outflow ObstructionVenoocclusive DiseaseAmyloidosisIschemiaNodular Regenerative HyperplasiaSECTION 8: TRANSPLANTATION PATHOLOGYIschemia Reperfusion InjuryAntibody-Mediated RejectionT-Cell-Mediated Rejection (Acute Cellular Rejection)Chronic RejectionCentral Perivenulitis/Parenchymal RejectionHepatic Artery ThrombosisGraft-vs.-Host DiseaseSECTION 9: TUMORS OF THE LIVERApproach to Liver Biopsy for Mass LesionsHepatectomy Specimen HandlingHepatocellular AdenomaFocal Nodular HyperplasiaRegenerative and Dysplastic NodulesHepatocellular Carcinoma and VariantsFibrolamellar CarcinomaCombined Hepatocellular-CholangiocarcinomaHepatoblastomaBile Duct Adenomavon Meyenburg Complex (Biliary Microhamartoma)Mucinous Cystic Neoplasm, LiverIntrahepatic CholangiocarcinomaIntrahepatic Cholangiocarcinoma, Histologic SubtypesIntraductal Papillary Neoplasm of Bile DuctHemangiomaAngiomyolipomaHepatic Small Vessel Neoplasm/Anastamosing HemangiomaEpithelioid HemangioendotheliomaInfantile HemangiomaAngiosarcomaMesenchymal HamartomaEmbryonal SarcomaInflammatory PseudotumorSegmental Atrophy (Nodular Elastosis)Tumors Metastatic to LiverSECTION 10: MISCELLANEOUS HEPATIC DISORDERSLangerhans Cell HistiocytosisHemophagocytic LymphohistiocytosisLiver Involvement in Systemic Liver DiseasesPART II: PANCREAS AND BILIARY TRACTSECTION 1: DEVELOPMENTAL/CONGENITAL DISORDERSCongenital Pancreatic CystCystic Fibrosis, PancreaticNesidioblastosisCholedochal CystSECTION 2: INFLAMMATORY DISORDERS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREECholelithiasisAcute CholecystitisChronic CholecystitisXanthogranulomatous CholecystitisEosinophilic CholecystitisPolyarteritis Nodosa and Other VasculitidesParasitic InfectionSECTION 3: NONNEOPLASTIC AND INFLAMMATORY DISORDERS OF THE PANCREASAcute PancreatitisChronic PancreatitisAutoimmune PancreatitisGroove PancreatitisInfectious PancreatitisPseudocystsDiabetes MellitusLymphoepithelial Cyst of the PancreasSECTION 4: TUMORS OF THE GALLBLADDER AND EXTRAHEPATIC BILIARY TREESpecimen Handling, GallbladderMass-Forming Intracholecystic NeoplasmCarcinoma of GallbladderCarcinoma of Extrahepatic Bile DuctsSquamous/Adenosquamous Carcinoma, GallbladderNeuroendocrine Neoplasms of GallbladderGranular Cell TumorEmbryonal RhabdomyosarcomaAdenomyomaNonneoplastic Polypoid Gallbladder LesionsSECTION 5: TUMORS OF THE PANCREASSpecimen Handling, WhipplePancreatic Intraepithelial NeoplasiaDuctal Adenocarcinoma, Including Histologic SubtypesUndifferentiated CarcinomaAdenosquamous Carcinoma, PancreasAcinar Cell CarcinomaSerous CystadenomaAcinar Cystic Transformation of the PancreasWell-Differentiated Neuroendocrine Tumor, PancreasPoorly Differentiated Neuroendocrine Carcinoma, PancreasGenomic Diagnosis of Intrahepatic Hepatobiliary TumorsRole of Genomics in Diagnosis of Pancreaticobiliary TumorsSimple Mucinous CystMucinous Cystic Neoplasm, PancreasIntraductal Papillary Mucinous NeoplasmIntraductal Oncocytic Papillary NeoplasmIntraductal Tubulopapillary NeoplasmSolid Pseudopapillary NeoplasmPancreatoblastomaDermoid CystSECTION 6: TUMORS OF THE AMPULLAAmpullary AdenomaAmpullary Adenocarcinoma and Histologic SubtypesWell-Differentiated Neuroendocrine Tumor, AmpullaComposite Gangliocytoma/Neuroma and Neuroendocrine Tumor/Gangliocytic Paraganglioma