Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery

Dr. Paley is Cofounder of the nonprofit Stop Alzheimers Corp and Founder of Expert Biomed, Inc. She holds a PhD degree in biology with specialization in molecular biology from the Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences in the Laboratory of Lev L. Kisselev. Dr. Paley’s research focuses mainly on protein biosynthesis in biology and diseases and is conducted in collaboration with Harvard University, Brandeis University, the University of Miami, Tel Aviv University, the Institut des Vaisseaux et du Sang (Paris, France), and the University of Texas at San Antonio. She is Adjunct Professor at Nova Southeastern University, FL, United States, and is inventor in patents issued and pending. Dr. Paley has previously published 4 books with Elsevier.

• 1. Introduction: Microbial metabolite interference of protein biosynthesis in neurodegenerative, neurodevelopmental, and other disorders; microbial metabolites hijacking vagus nerve2. COVID-19: Scientific progress3. Viral-bacterial interactions in diseases4. Vagus nerve: Acid reflux, parietal cells, carpal tunnel syndrome, Alzheimer’s disease, COVID-19, stroke, cancer, and other diseases5. Vagus nerve circuit: Microbiome—tryptophan metabolites—receptors and synapses6. Glutamate and glutamate receptors in vagus nerve pathways and in Alzheimer’s disease7. Aminoacyl tRNA synthetase multiple forms in autoimmune and infectious diseases8. Crystalized aromatic l-amino acid decarboxylase from bacteria Micrococcus percitreus catalyzing decarboxylation of tryptophan and l-DOPA (Levodopa or 3,4-dihydroxy-l-phenylalanine)9. Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water10. Microbial antigens, allergies, and antibodies to microbial allergens: Significance of preexisting antibodies and stress for vaccination11. Smell and taste identification deficits in disease12. Microorganisms producing biogenic amines: From food to human body13. Human genome or human microbiome genes: Which one is more important for human health and intellectual abilities?14. Microorganisms used in agriculture, consumed from environment and associated with the edible raw fruits, vegetables, herbs, sprouts, and mushrooms15. Molecular and cell aggregation: Biogenic amines, proteins, platelets, and microbial pathogens16. Colonic diverticular disease as a risk factor for neurodegenerative and associated diseases17. Alzheimer’s disease, dementia, aging, and COVID-1918. Existing vaccines and new and old tools19. Serotonin syndrome in neurodegenerative diseases and COVID-19: Mechanisms and consequences of intestinal infection20. Circulating cell-free mitochondria and membrane vesicles21. Protein synthesis inhibition in neuronal activities22. Rosacea and associated medical disorders23. Bacterial internalization in cancer and other medical conditions: Intracellular pathogens24. Ocular changes resulting from reading and writing on smartphone and computer: Computer vision syndrome, dry eye disease, meibomian gland dysfunction, chalazion, occupational overuse syndrome25. Viral infections in vagus nerve26. Microbial tryptamine in Type 1, Type 2, and Type 3 diabetes