Since the first Paleoamerican Odyssey conference, new research has deepened our understanding of the peopling of the Americas. Revolutionary genetic methodologies, combined with developments in archaeology, geology, and paleoecology, have generated new insights into the timing and patterns of early dispersal events and the technologies and lifeways of the first Americans during the late Pleistocene and early Holocene. We now know that humans first migrated from northeastern Asia, and upon arrival in North America, they moved south, either along the deglaciated Pacific coast, through the Ice Free Corridor, or both to what is now continental North and South America. However, as archaeologists continue to shed light onto the movements of the first Americans, the story becomes ever more complicated.Paleoamerican Odyssey, 100 Years Beyond Folsom presents twenty-nine original papers from experts at the 2026 Paleoamerican Odyssey conference. These works provide summaries of the late Pleistocene archaeology of every major region in the Americas and explore exciting new discoveries from newly reported and reinvestigated sites, new chronological models for major cultural complexes in North and South America, and cutting edge technologies and theoretical models for understanding the Indigenous first peoples on this continent.