Genome Integrity

Facets and Perspectives

AvDirk-Henner Lankenau

Häftad, Engelska, 2010

Del i serien Genome Dynamics and Stability

3 328 kr

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Beskrivning

Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions.

Produktinformation

Utgivningsdatum:2010-11-25
Mått:155 x 235 x 30 mm
Vikt:752 g
Format:Häftad
Språk:Engelska
Serie:Genome Dynamics and Stability
Antal sidor:496
Förlag:Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN:9783642072260

Utforska kategorier

Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Medicinsk genetik inom Medicin

Innehållsförteckning

Replication.- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories.- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork.- DNA Polymerases and Diseases.- Replicative Double-Strand Break Repair.- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing.- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution.- Facets of Double-Strand Break Repair.- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology.- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays.- Role of p53 in Double-Strand Break Repair.- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks.- DNA Repair and Pleiotropic Interactions.- DNA Base Damage Recognition and Processing.- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity.- Role of Human Topoisomerase I in DNA Repair and Apoptosis.- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome.- Radiation and other Genotoxic Stress.- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress.- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation.- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin.- Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.