Biotechnological Applications of Quorum Sensing Inhibitors

Dr. Vipin Chandra Kalia is a Professor at Molecular Biotechnology Lab, Department of Chemical Engineering, Konkuk University, Seoul, Korea. He has been an Emeritus Scientist and ex-Chief Scientist at Microbial Biotechnology and Genomics, CSIR Institute of Genomics and Integrative Biology, Delhi. He received his M.Sc. and Ph.D. degrees in Genetics from the Indian Agricultural Research Institute, New Delhi. He has been elected as a Fellow of the Association of Microbiologists of India (FAMSc), National Academy of Sciences (FNASc), and National Academy of Agricultural Sciences (FNAAS). His main areas of research are Microbial Biodiversity, Genomics and Evolution, Bioenergy, Biopolymers, Antimicrobials, Quorum Sensing, and Quorum Quenching. He has published over 100 papers in scientific journals such as Nature Biotechnology, Biotechnology Advances, and Trends in Biotechnology.He has edited 11 books, is currently Editor in Chief of the Indian Journal of Microbiology, and serves as an editor for several other journals. He is a life member of e.g. the Society of Biological Chemists of India, the Society for Plant Biochemistry and Biotechnology, India, and the Biotech Research Society of India (BRSI). He has been conferred numerous awards, including the Prof. S.R. Vyas Memorial Award, Association of Microbiologists of India (2016), ASM-IUSSF Indo-US Professorship Program, American Society of Microbiologists, USA (2014), and the Dr. J.V Bhat Award, Association of Microbiologists of India (2012, 2015, 2016, 2017). He can be contacted at: vckalia@igib.in or vc_kalia@yahoo.co.in.

• A. Human Health.- Inhibition of Quorum-sensing: a new paradigm in controlling bacterial virulence and biofilm formation.- Targeting Quorum Sensing Mediated Staphylococcus aureus Biofilms: A Proteolytic Approach.- Alternative strategies for control of quorum sensing and biofilm formation of pathogenic Pseudomonas aeruginosa by plant, marine and synthetic based quorum sensing inhibitors.- Quorum Quenching and Biofilm Inhibition: Alternative imminent strategies to control the disease Cholera.-  Anti-biofilm peptides: A new class of quorum quenchers and their prospective therapeutic applications.- Quorum sensing inhibition: A target for treating chronic wounds.- Efflux pump-mediated quorum sensing—new avenues for modulation of antimicrobial resistance and bacterial virulence.- CRISPR-Cas systems regulate quorum sensing genes and alter virulence in bacteria.- Developing Anti-virulence Chemotherapies by Exploiting the Diversity of Microbial Quorum Sensing Systems.- Synergism between quorum sensing inhibitors and antibiotics: Combating the antibiotic resistance crisis.- Nanoparticles as quorum sensing inhibitor: Prospects and limitations.- Nanotechnological Approaches in Quorum sensing Inhibition.- Bacterial-mediated biofouling: Fundamentals and control techniques.- Technological developments in quorum sensing and its inhibition for medical applications.- Combating Staphylococcal Infections Through Quorum Sensing Inhibitors. B. Plant Health.- Marine biodiversity as a resource for bioactive molecules as inhibitors of microbial quorum sensing phenotypes.- Quorum Sensing in plant pathogenic bacteria and its relevance in plant health.- Scope of pathogenesis-related proteins produced by plants in interrupting quorum sensing signaling.- Bioactive phytochemicals targeting microbial activities mediated by quorum sensing.- Quorum sensing interference by natural products from medicinal plants: Significance in combating bacterial infection.- EnzymaticQuorum Quenching for Virulence Attenuation of Phytopathogenic Bacteria.