Jim E. Riviere – författare

A very high portion of the seafood we eat comes from abroad, mainly from China and Southeast Asia, and most of the active ingredients in medicines we take originate in other countries. Many low- and middle-income countries have lower labor costs and fewer and less stringent environmental regulations than the United States, making them attractive places to produce food and chemical ingredients for export. Safe Foods and Medical Products Through Stronger Regulatory Systems Abroad explains that the diversity and scale of imports makes it impractical for U.S. Food and Drug Administration (FDA) border inspections to be sufficient to ensure product purity and safety, and incidents such as American deaths due to adulterated heparin imported from China propelled the problem into public awareness. The Institute of Medicine Committee on Strengthening Core Elements of Regulatory Systems in Developing Countries took up the vital task of helping the FDA to cope with the reality that so much of the food, drugs, biologics, and medical products consumed in the United States originate in countries with less-robust regulatory systems.Ensuring Safe Foods and Medical Products Through Stronger Regulatory Systems Abroad describes the ways the United States can help strengthen regulatory systems in low and middle income countries and promote cross-border partnerships - including government, industry, and academia - to foster regulatory science and build a core of regulatory professionals. This report also emphasizes an array of practical approaches to ensure sound regulatory practices in today's interconnected world.

Highlighting international approaches; the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock. Focuses attention on drug and chemical residues in edible animal productsCovers novel computational, statistical, and mathematical strategies for dealing with chemical exposures in food animalsDetails major drug classes used in food animal production and their residue risksHighlights efforts at harmonizing and the differences among areas like US, EU, Canada, Australia, South America, China, and Asia, where the issue of chemical exposures has significant impact on livestock productsTies veterinary clinical practice and the use of these drugs in food animals with regulatory standards and mitigation practices

Chemical Food Safety: A Scientist's Perspective introduces readers to the science of risk assessment as applied to food safety and offers relevant, current information on research and statistics, chemicals, biotechnology issues, and emerging diseases that challenge the risk assessment strategies of toxicology and microbiology.Riviere investigates the potential health consequences of pesticides, food additives and drugs, demonstrating how science can be applied to make risk assessments. He differentiates between “real risks” and “phantom risks,” unearthing numerous fallacies in the public perception of risk assessment and evidence of people’s intolerance to certain types of risks—no matter how remote. Chemical Food Safety is based on credible, scientifically correct data rather than irrational fears propagated by media coverage concerning food safety. The book explores these riveting topics:*food security and the world of bioterrorism,*toxicity of natural compounds and artificial additives in foods,*the toxicology of pesticides in food,*issues of biotechnology and genetically modified food,*other compelling issues in chemical food safety.With its focus on how the results of toxicology are applied in the real world, Chemical Food Safety: A Scientist’s Perspective will be a valuable addition to the libraries of food scientists, dieticians, animal producers, veterinarians and anyone else with a professional or personal interest in risk assessment, toxicology, epidemiology or food safety.

The use of therapeutic and antimicrobial agents to prevent, to control, and to eradicate disease in herd animals has without question revolutionized food animal production capacity. But how much of a good thing is too much? 20th century advances in disease diagnosis and treatment have led to 21st century concerns about the health risks posed to consumers when the animals they consume have been exposed to antimicrobials, therapeutic drugs, pesticides and other environmental contaminants. The Food Animal Residue Avoidance Databank provides the pharmacologic data that veterinarians and producers need to screen animals that have been exposed to chemicals and to ensure that dangerously contaminated tissues of food-producing animals do not enter the human food chain. Established only twenty years ago under the auspices of the USDA, FARAD is an international venture that brings together and collates information on applications of pharmacokinetic principles to drug and chemical residue avoidance—information that previously has been spread throughout the literature. Now, the Tabulation of FARAD Comparative and Veterinary Pharmacokinetic Data brings together in a single source all the most current information on chemical residues in food animals, and provides easy access and numerous tables that offer essential pharmacokinetic data for chemicals in serum, plasma, blood, or in other matrices. This updated one-of-a-kind volume also features additional data on laboratory rodents, dogs, cats, and horses to facilitate broader interspecies extrapolations. This easy-to-use and newly-updated publication is the essential reference on the subject and belongs in the library of veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.

Now in a revised edition, Comparative Pharmacokinetics: Principles, Techniques, and Applications presents the principles and techniques of comparative and veterinary pharmacokinetics in a detailed yet practical manner. Developed as a tool for ensuring that pharmacokinetics studies are properly designed and correctly interpreted, the book provides complete coverage of the conceptual basis of pharmacokinetics as used for quantifying biological processes from the perspectives of physiology and medicine.  New chapters have been added on quantitative structure permeability relationships and bioequivalence, and a number of existing chapters have been significantly revised and expanded to provide a current resource for veterinary and comparative pharmacokinetics.

Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicology in years to come including proteomics, toxicogenomics, and metabonomics, this expertly conceived guide explores toxicological issues of particular world interest, such as toxicity of nanomaterials, military jet fuels, and genetically-modified foods.

Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species. Provides current, detailed information on using drug therapies in all major domestic animal speciesOrganized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicineIncludes extensive tables of pharmacokinetic data, products available, and dosage regimensAdds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacologyIncludes access to a companion website with the figures from the book in PowerPoint

The major objective of this handbook is to compile-in tabular form-the pharmacokinetic parameters of antimicrobial drugs used in food animals. This unique publication represents data from the FARAD (Food Animal Residue Avoidance Databank) databank, established by the authors under the auspices of the U.S.D.A. and contains significant amounts of previously unavailable information. This updated, one-of-a-kind volume even features additional data on laboratory rodents, dogs, cats, and horses in order to facilitate broader interspecies extrapolations. This easy-to-use reference is timely as well as invaluable to animal scientists, veterinarians, pharmacologists, and toxicologists who work with antimicrobials in chickens, turkeys, dairy and beef cattle, swine, goats, and sheep.