Comparative Pharmacokinetics

Jim Riviere, DVM, PhD, DSc (hon), ATS, is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology, Alumni Distinguished Graduate Professor, and Director of the Center for Chemical Toxicology Research and Pharmacokinetics at North Carolina State University, and Editor of the Journal of Veterinary Pharmacology and Therapeutics.

"This book is helpful in understanding and designing pharmacokinetic studies, illustrating basic concepts and noting the species differences. . . The book does a good job of explaining a concept and then expands with more specific examples. It provides a good base for pharmacokinetic modeling and illustrates the pitfalls with interspecies extrapolation." (Doody's, 21 October 2011)

• Coauthors. Preface.1 Introduction.2 Principles of Drug Movement in the Body.3 Quantitative Structure–Permeability Relationships (Xin-Rui Xia).4 Absorption.5 Distribution (with Jennifer Buur).6 Renal Elimination.7 Hepatic Biotransformation and Biliary Excretion (Ronald Baynes).8 Compartmental Models.9 Noncompartmental Models.10 Nonlinear Models.11 Physiological Models (Teresa Leavens).12 Dosage Regimens.13 Simultaneous Pharmacokinetic–Pharmacodynamic Modeling (Pierre-Louis Toutain).14 Study Design and Data Analysis. (Jason Chittenden).15 Bioequivalence Studies (Marilyn Martinez).16 Population Pharmacokinetic Models (Jason Chittenden).17 Dosage Adjustments in Disease States (Jennifer Davis).18 Interspecies Extrapolations.19 Tissue Residues and Withdrawal Times (Sharon Mason).Index.