Veterinary Pharmacology and Therapeutics

The editorsJim E. Riviere, DVM, PhD, DSc (hon), ATS, is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA. Mark G. Papich, DVM, MS, Diplomate ACVCP, has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA.

• Contributors xiiiPreface xixAbout the Companion Website xxiSection 1 Principles of Pharmacology 11 Veterinary Pharmacology: An Introduction to the Discipline 3Jim E. Riviere and Mark G. Papich1 Absorption, Distribution, Metabolism, and Elimination 8Jim E. Riviere3 Pharmacokinetics 41Jim E. Riviere4 Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage RegimenOptimization for Veterinary Medicine 65Pierre-Louis Toutain5 Principles of Pharmaceutics and Veterinary Dosage Forms 87Raafat M. Fahmy and Marilyn N. MartinezSection 2 Drugs Acting on the Autonomic Nervous System 1116 Introduction to the Autonomic Nervous System and Autonomic Pharmacology 113Joshua A. Rowe, Rose M. McMurphy, Barbara J. Lutjemeier, and Michael J. Kenney7 Adrenergic Receptor Agonists and Antagonists 131Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney8 Cholinergic Pharmacology: Autonomic Drugs 151Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Marjory A. Artzer, Barbara J. Lutjemeier, and Michael J. KenneySection 3 Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 1659 Introduction to Drugs Acting on the Central Nervous System and Principles of Anesthesiology 167Peter J. Pascoe and Eugene P. Steffey10 Neuromuscular Blocking Agents 194Diane E. Mason and Christopher L. Norkus11 Inhalation Anesthetics 216Robert J. Brosnan and Eugene P. Steffey12 Injectable Anesthetic Agents 247Lysa P. Posner13 Opioid Analgesic Drugs 281Butch KuKanich and Mark G. Papich14 Sedatives and Tranquilizers 324Lysa P. Posner15 Local Anesthetics 369Thomas W. Vickroy16 Euthanizing Agents 387Anna Hampton17 Anticonvulsant Drugs 395Mark G. Papich18 Drugs Affecting Animal Behavior 416Margaret E. Gruen, Barbara L. Sherman, and Mark G. PapichSection 4 Autacoids and Antiinflammatory Drugs 44919 Histamine, Serotonin, and their Antagonists 451Wolfgang Baumer20 Analgesic, Antiinflammatory, Antipyretic Drugs 467Peter LeesSection 5 Drugs Acting on the Cardiovascular System 50121 Digitalis, Positive Inotropes, and Vasodilators 503Clarke E. Atkins and Marisa K. Ames22 Antiarrhythmic Agents 537Kathryn M. Meurs and Jim E. RiviereSection 6 Drugs Affecting Renal Function and Fluid– Electrolyte Balance 55323 Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar24 Diuretics and Renal Pharmacology 593Butch Kukanich and Deborah T. KochevarSection 7 Drugs Acting on Blood and Blood Elements 62325 Anticoagulant, Antiplatelet, and Hemostatic Drugs 625Mark G. PapichSection 8 Endocrine Pharmacology 64726 Hypothalamic and Pituitary Hormones 649Srujana Rayalam, Margarethe Hoenig, and Duncan C. Ferguson27 Hormones Affecting Reproduction 674Wolfgang Baumer, C. Scott Bailey, and John Gadsby28 Thyroid Hormone and Antithyroid Drugs 691Duncan C. Ferguson29 Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729Duncan C. Ferguson and Margarethe Hoenig30 Drugs Influencing Glucose Metabolism 763Margarethe HoenigSection 9 Chemotherapy of Microbial Diseases 77931 Antiseptics and Disinfectants 781Megan E. Jacob32 Sulfonamides and Potentiated Sulfonamides 796Mark G. Papich33 Β-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 826Mark G. Papich34 Tetracycline Antibiotics 858Mark G. Papich and Jim E. Riviere35 Aminoglycoside Antibiotics 877Mark G. Papich and Jim E. Riviere36 Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials 903Mark G. Papich37 Fluoroquinolone Antimicrobial Drugs 953Mark G. Papich38 Antifungal and Antiviral Drugs 988Jennifer L. Davis and Lara MaxwellSection 10 Chemotherapy of Parasitic Diseases 103339 Antinematodal Drugs 1035Carlos E. Lanusse, Juan M. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez40 Anticestodal and Antitrematodal Drugs 1081Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel41 Macrocyclic Lactones: Endectocide Compounds 1102Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz42 Antiprotozoan Drugs 1128Jennifer L. Davis and Jody L. Gookin43 Ectoparasiticides 1166Ronald E. BaynesSection 11 Specialty Areas of Pharmacology 118944 Chemotherapy of Neoplastic Diseases 1191Luke A. Wittenburg and Daniel L. Gustafson45 Immunosuppressive Drugs 1226Mark G. Papich46 Drugs for Treating Gastrointestinal Diseases 1245Mark G. Papich47 Dermatopharmacology: Drugs Acting Locally on the Skin 1278Jim E. Riviere and Rosanna Marsella48 Drugs that Affect the Respiratory System 1302Mark G. Papich49 Ophthalmic Pharmacology 1321Alison Clode50 Pharmacogenomics 1332Katrina L. Mealey51 Considerations for Treating Minor Food-Producing Animals with Veterinary Pharmaceuticals 1345Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring52 Unique Considerations Pertaining to the Use of Drugs in Food Animals 1358Michael D. Apley53 Pharmacology in Aquatic Animals 1373Ron A. Miller54 Zoological Pharmacology 1395Robert P. HunterSection 12 Regulatory and Other Considerations 140555 The Regulation of Animal Drugs 1407Steven D. Vaughn and Marilyn N. Martinez56 Veterinary Pharmacy 1427Gigi Davidson and Mark G. Papich57 Medication Control Programs in Performance Animals 1439Cynthia A. Cole58 Pharmacovigilance 1448John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer59 Dosage Forms And Veterinary Feed Directives 1459Geof Smith and Jim E. Riviere60 Evidence-Based Pharmacotherapy 1465Ronette Gehring61 Chemical Residues In Tissues Of Food Animals 1469Jim E. RiviereIndex 1481