Ronald Baynes is a Professor of Pharmacology and Director of the Center of Chemical Toxicology Research and Pharmacokinetics at the College of Veterinary Medicine at North Carolina State University and Fellow, American Academy of Veterinary Pharmacology and Therapeutics He has consulted for the National Institute of Environmental Health Sciences, the US Environmental and Protection Agency, and National Institute of Occupational Safety and Health on chemical exposure-related topics. Jim Riviere is The MacDonald Chair in Veterinary Medicine and University Distinguished Professor at Kansas State University. He is an elected member of the Institute of Medicine of the National Academies, serves on its Food and Nutrition Board, and is a fellow of the Academy of Toxicological Sciences.

“This book is an excellent resource for those interested in an overview of drug residue issues across multiple species.”  (Journal of the American Veterinary Medical Association, 15 March 2015)

• Preface viiContributors ix1 Importance of Veterinary Drug Residues 1Ronald E. Baynes and Jim E. Riviere2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination ofWithdrawal Periods for Animal Drugs 9Sanja Modric3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals forEstablishing Withdrawal Periods and Milk Discard Times 35Dong Yan4 Establishing Maximum Residue Limits in Europe 49Kornelia Grein and Isaura Duarte5 Methods to Derive Withdrawal Periods in the European Union 65G. Johan Schefferlie and Stefan Scheid6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 81Sharon E. Mason7 Physiologically Based Pharmacokinetic Modeling 95Jennifer Buur8 Residue Avoidance in Beef Cattle Production Systems 115Virginia Fajt and Dee Griffin9 Residue Avoidance in Dairy Cattle Production Systems 137Geof Smith10 Residue Avoidance in Aquaculture Production Systems 161Renate Reimschuessel11 Residue Avoidance in Small Ruminant Production Systems 193Kevin Anderson and Reha Azizoglu12 Residue Avoidance in Swine Production Systems 221Ronald E. Baynes and Glen Almond13 Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in Livestock Commodities233Hui li14 The Food Animal Residue Avoidance Databank: An Example of Risk Management of VeterinaryDrug Residues 289Thomas W. Vickroy, Ronald E. Baynes, Lisa Tell and Jim E. Riviere15 Risk Management of Chemical Contaminants in Livestock 303Ronald E. Baynes and Jim E. RiviereIndex 313

Ronald Baynes is a Professor of Pharmacology and Director of the Center of Chemical Toxicology Research and Pharmacokinetics at the College of Veterinary Medicine at North Carolina State University and Fellow, American Academy of Veterinary Pharmacology and Therapeutics He has consulted for the National Institute of Environmental Health Sciences, the US Environmental and Protection Agency, and National Institute of Occupational Safety and Health on chemical exposure-related topics. Jim Riviere is The MacDonald Chair in Veterinary Medicine and University Distinguished Professor at Kansas State University. He is an elected member of the Institute of Medicine of the National Academies, serves on its Food and Nutrition Board, and is a fellow of the Academy of Toxicological Sciences.

“This book is an excellent resource for those interested in an overview of drug residue issues across multiple species.”  (Journal of the American Veterinary Medical Association, 15 March 2015)

• Preface viiContributors ix1 Importance of Veterinary Drug Residues 1Ronald E. Baynes and Jim E. Riviere2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination ofWithdrawal Periods for Animal Drugs 9Sanja Modric3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals forEstablishing Withdrawal Periods and Milk Discard Times 35Dong Yan4 Establishing Maximum Residue Limits in Europe 49Kornelia Grein and Isaura Duarte5 Methods to Derive Withdrawal Periods in the European Union 65G. Johan Schefferlie and Stefan Scheid6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 81Sharon E. Mason7 Physiologically Based Pharmacokinetic Modeling 95Jennifer Buur8 Residue Avoidance in Beef Cattle Production Systems 115Virginia Fajt and Dee Griffin9 Residue Avoidance in Dairy Cattle Production Systems 137Geof Smith10 Residue Avoidance in Aquaculture Production Systems 161Renate Reimschuessel11 Residue Avoidance in Small Ruminant Production Systems 193Kevin Anderson and Reha Azizoglu12 Residue Avoidance in Swine Production Systems 221Ronald E. Baynes and Glen Almond13 Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in Livestock Commodities233Hui li14 The Food Animal Residue Avoidance Databank: An Example of Risk Management of VeterinaryDrug Residues 289Thomas W. Vickroy, Ronald E. Baynes, Lisa Tell and Jim E. Riviere15 Risk Management of Chemical Contaminants in Livestock 303Ronald E. Baynes and Jim E. RiviereIndex 313

Ronald Baynes is a Professor of Pharmacology and Director of the Center of Chemical Toxicology Research and Pharmacokinetics at the College of Veterinary Medicine at North Carolina State University and Fellow, American Academy of Veterinary Pharmacology and Therapeutics He has consulted for the National Institute of Environmental Health Sciences, the US Environmental and Protection Agency, and National Institute of Occupational Safety and Health on chemical exposure-related topics. Jim Riviere is The MacDonald Chair in Veterinary Medicine and University Distinguished Professor at Kansas State University. He is an elected member of the Institute of Medicine of the National Academies, serves on its Food and Nutrition Board, and is a fellow of the Academy of Toxicological Sciences.

“This book is an excellent resource for those interested in an overview of drug residue issues across multiple species.”  (Journal of the American Veterinary Medical Association, 15 March 2015)

• Preface viiContributors ix1 Importance of Veterinary Drug Residues 1Ronald E. Baynes and Jim E. Riviere2 Pharmacokinetic Principles for Understanding Drug Depletion as a Basis for Determination ofWithdrawal Periods for Animal Drugs 9Sanja Modric3 Evaluation of Drug Residue Depletion in the Edible Products of Food-Producing Animals forEstablishing Withdrawal Periods and Milk Discard Times 35Dong Yan4 Establishing Maximum Residue Limits in Europe 49Kornelia Grein and Isaura Duarte5 Methods to Derive Withdrawal Periods in the European Union 65G. Johan Schefferlie and Stefan Scheid6 Population Pharmacokinetic Modeling to Predict Withdrawal Times 81Sharon E. Mason7 Physiologically Based Pharmacokinetic Modeling 95Jennifer Buur8 Residue Avoidance in Beef Cattle Production Systems 115Virginia Fajt and Dee Griffin9 Residue Avoidance in Dairy Cattle Production Systems 137Geof Smith10 Residue Avoidance in Aquaculture Production Systems 161Renate Reimschuessel11 Residue Avoidance in Small Ruminant Production Systems 193Kevin Anderson and Reha Azizoglu12 Residue Avoidance in Swine Production Systems 221Ronald E. Baynes and Glen Almond13 Confirmatory Methods for Veterinary Drugs and Chemical Contaminants in Livestock Commodities233Hui li14 The Food Animal Residue Avoidance Databank: An Example of Risk Management of VeterinaryDrug Residues 289Thomas W. Vickroy, Ronald E. Baynes, Lisa Tell and Jim E. Riviere15 Risk Management of Chemical Contaminants in Livestock 303Ronald E. Baynes and Jim E. RiviereIndex 313