In this issue of Primary Care: Clinics in Office Practice, guest editor Dr. Vincent Morelli brings his considerable expertise to the topic of AI in Primary Care. Top experts demystify artificial intelligence and introduce basic concepts of AI in primary care, including how to understand AI outputs, acknowledge limitations, and reveal key AI technologies relevant to healthcare. Additional articles discuss how AI can aid in patient diagnosis, management, and workflows. Contains 13 relevant, practice-oriented topics including AI in risk assessment and prevention; AI and social determinants of health; AI in diagnosis and clinical decision making; integrating AI solutions into administrative medicine and practice workflows; ethical and legal considerations; the future of AI in primary care; and more Provides in-depth clinical reviews on AI in primary care, offering actionable insights for clinical practice Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews