John Waddington is currently Professor of Neuroscience in Molecular and Cellular Therapeutics at the Royal College of Surgeons in Ireland (RCSI), Dublin. He received a BA in Natural Sciences from the University of Cambridge, and a PhD in Neuropharmacology followed by a DSc in Neuroscience from the University of London. After working with the UK Medical Research Council in the Division of Psychiatry at their Clinical Research Centre, he joined RCSI and became Chairman of Clinical Pharmacology in 2004. In 2003, he became the first person from RCSI to be elected to membership of the Royal Irish Academy; he has received the Lilly Neuroscience Award from the International College of Neuropsychopharmacology and the Award for Outstanding Achievement in Basic Science from the Schizophrenia International Research Society. His research is focused on the pathobiology and psychopharmacology of psychotic illness, mutant models of schizophrenia and other psychoses, and the pathobiology, psychopharmacology and mutant modelling of movement disorder.John Waddington is currently Professor of Neuroscience in Molecular and Cellular Therapeutics at the Royal College of Surgeons in Ireland (RCSI), Dublin. He received a BA in Natural Sciences from the University of Cambridge, and a PhD in Neuropharmacology followed by a DSc in Neuroscience from the University of London. After working with the UK Medical Research Council in the Division of Psychiatry at their Clinical Research Centre, he joined RCSI and became Chairman of Clinical Pharmacology in 2004. In 2003, he became the first person from RCSI to be elected to membership of the Royal Irish Academy; he has received the Lilly Neuroscience Award from the International College of Neuropsychopharmacology and the Award for Outstanding Achievement in Basic Science from the Schizophrenia International Research Society. His research is focused on the pathobiology and psychopharmacology of psychotic illness, mutant models of schizophrenia and other psychoses, and the pathobiology, psychopharmacology and mutant modelling of movement disorder.

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• 1. Behavioural Pharmacology of Orofacial Movement DisorderNoriaki Koshikawa, Satoshi Fujita, Kazunori Adachi2 Regulation of Orofacial Movement: Dopamine Receptor Mechanisms and Mutant ModelsJohn L. Waddington, Gerard J. O’Sullivan and Katsunori Tomiyama3 Regulation of Orofacial Movement: Amino Acid Mechanisms and Mutant ModelsKatsunori Tomiyam, Colm M. P. O’Tuathaigh4 and John L. Waddington34 The Trigeminal Circuits Responsible for ChewingKarl-Gunnar Westberg, and Arlette Kolta5 Ultrastructural Basis for Craniofacial Sensory Processing in the BrainstemYong Chul Bae, Atsushi Yoshida6 Mechanisms of Nociceptive Transduction and Transmission: A Mashinery for Pain Sensation and Tools for Selective Analgesia.Alexander M. Binshtok7 Peripheral and central mechanisms of orofacial Inflammatory painBarry J. Sessle8 The Role of Trigeminal Interpolaris-Caudalis Transition Zone in Persistent Orofacial PainKe Ren and Ronald Dubner9 Physiological Mechanisms of Neuropathic Pain: The Orofacial RegionKoichi Iwata, Yoshiki Imamura, Kuniya Honda1, and Masamichi Shinoda10 Neurobiology of Estrogen Status in Deep Craniofacial PainDavid A Bereiter and Keiichiro Okamoto11 Macroscopic Connection of Rat Insular Cortex: Anatomical Bases Underlying Its Physiological Functions Masayuki Kobayashi12 The Balance between Excitation and Inhibition and Functional Sensory Processing in the Somatosensory CortexZhi Zhang and Qian-Quan Sun