Neuropsychopharmacology: A Tribute to Joseph T. Coyle

Dr. Robert Schwarcz is Professor of Psychiatry, Pharmacology and Pediatrics, Director of the NIMH Conte Center for Translational Research, and Head of Neuroscience, Maryland Psychiatric Research Center, at the University of Maryland School of Medicine. After receiving his PhD degree in Biochemistry from the University of Vienna, Austria, he showed in the 1970s, under the mentorship of Dr. Coyle, that an intrastriatal injection of the excitatory amino acid kainate provides an animal model for Huntington's disease. This led to the idea that excitotoxic processes, triggered by an overstimulation of excitatory amino acid receptors, are causally involved in the pathophysiology of several major neurological diseases.As an offshoot of the excitotoxic hypothesis, Dr. Schwarcz developed the concept and demonstrated that antagonists of excitatory amino acid ("glutamate") receptors prevent or arrest neurodegeneration and hold promise as novel therapeutic agents for major brain diseases. This eventually led to the establishment of anti-excitotoxin-based drug discovery programs in a large number of pharmaceutical houses throughout the world.More recently, most of Dr. Schwarcz’ work has been concerned with the neurobiology of quinolinate (QUIN) and kynurenate (KYNA), two metabolically related brain constituents with neuroexcitatory (and excitotoxic) and neuroinhibitory (and neuroprotective) properties, respectively. Both QUIN and KYNA are products of the kynurenine pathway of tryptophan degradation. Using a combination of biochemical, histological, behavioral and electrophysiological techniques, he elaborated many of the characteristics and control mechanisms which govern the function of QUIN and KYNA in the brain. Ongoing in vivo and in vitro studies are designed 1) to identify possible abnormalities in kynurenine pathway metabolism in Huntington’s disease, schizophrenia and depression, and in relevant animal models; 2) to further define the neurobiology of QUIN and KYNA by manipulating the kynurenine pathway pharmacologically and genetically; and 3) to develop and use novel kynurenergic drugs in order to normalize functional impairments in the central nervous system.Dr. Schwarcz has published over 300 peer-reviewed manuscripts and received several major national and international awards and honors, including election as Foreign Professor of the Karolinska Institute in Stockholm in 2009.

Praise for the Series: "...recommended not only to pharmacologists but also to all those in related disciplines" --Nature

• PrefaceRobert Schwarcz and S.J. EnnaForewordSolomon H. Snyder1. My Life in Clinical Neuroscience: The Beginning Joseph T Coyle2. Kynurenines and Glutamate: Multiple Links and Therapeutic ImplicationsRobert Schwarcz3. The Therapeutic Role of D-Cycloserine in SchizophreniaDonald Goff4. Impulsivity, Stimulant Abuse and Dopamine Receptor SignalingEdythe D. London5. Excitotoxicity as a Common Mechanism for Fetal Neuronal Injury with Hypoxia and Intrauterine InflammationIrina Burd, Jared Welling, Gokul Kannan, Michael V. Johnston6. Transcriptional Regulation of Glutamate Transporters: From Extracellular Signals to Transcription FactorsZila Martinez-Lozada, Alain M. Guillem and Michael B. Robinson7. The Long and Winding Road: From the High Affinity Choline Uptake Site to Clinical Trials for Malignant Brain TumorsPedro R. Lowenstein and Maria G. Castro8. Choline on the Move: Perspectives on the Molecular Physiology and Pharmacology of the Presynaptic Choline TransporterElizabeth A. Ennis and Randy D. Blakely9. Still NAAG’ing after all these Years: The Continuing Pursuit of GCPII InhibitorsJames J. Vornov, Kristen R. Hollinger, Paul F. Jackson, Krystyna M. Wozniak, Mohamed H. Farah, Pavel Majer, Rana Rais and Barbara S. Slusher10.  Ultimate Translation; Developing Therapeutics Targeting on N-methyl-D-aspartate ReceptorGuochuan Emil Tsai11.  The Good and Bad Sides of NAAGPamela Khacho, Boyang Wang and Richard Bergeron12.  The NMDA Receptor and Schizophrenia: From Pathophysiology to TreatmentDarrick T. Balu