Wanda M. Haschek-Hock, BVSc, Ph.D., is a Diplomate of the American College of Veterinary Pathologists (DACVP), Fellow of the International Academy of Toxicologic Pathology (FIATP), and Honorary Member of the Latin American Society of Toxicologic Pathology. She is Professor Emerita at the University of Illinois College of Veterinary Medicine, Department of Pathobiology. Wanda has over 40 years of experience in comparative, respiratory, and toxicologic pathology with a research focus on natural toxins and food safety. She is a former President of the Society of Toxicologic Pathology (STP) and of the Society of Toxicology’s (SOT) Comparative and Veterinary Specialty Section and has served as an Associate Editor for Toxicological Sciences and Toxicologic Pathology, as Councilor of the American College of Veterinary Pathologists (ACVP), and as Member of the American Board of Toxicology (ABT). She served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. She is a recipient of the STP’s Lifetime Achievement Award, the SOT Midwest Regional Chapter’s Kenneth DuBois Award, and the University of Sydney Faculty of Veterinary Science Alumni Award for International Achievement in 2016. Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

*5 stars* "…the single leading reference on the practices of toxicologic pathology in areas of basic principles, laboratory safety and assessment, and organ-specific toxicity [that] strives to have the most up-to-date and innovative advances in one resource…. [A] convenient, all-in-one resource covering most, if not all, aspects of toxicologic pathology,… an essential resource that is tailored to be utilized at all levels of training and experience, making this book an invaluable investment that one would use throughout their career. This new edition has been expanded to include the vast number of advances that have occurred over the past five years since its last edition, making this the most reliable and up-to-date resource in toxicologic pathology today. The illustrations and photos are clear and serve to reinforce concepts as well as noteworthy characteristics. Every individual in the toxicology field, whether by industry, practice, or training, should have this book as a reference they will use for a lifetime." --©Doody’s Review Service, 2023, Isabella Marie Dishong, DO (University of Michigan Medical School)

• 1. Toxicology Pathology: An IntroductionPart 1 Principles of Toxicologic Pathology2. Biochemical and Molecular Basis of Toxicity3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective4. Biotherapeutic ADME and PK/PD Principles5. Principles of Pharmacodynamics and Toxicodynamics6. Morphologic Manifestations of Toxic Cell Injury7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity8. Carcinogenesis: Mechanisms and EvaluationPart 2 Methods in Toxicologic Pathology9. Basic Approaches to Anatomic Toxicologic Pathology10. Clinical Pathology in Nonclinical Toxicity Testing11. Special Techniques in Toxicologic Pathology12. Digital Pathology and Tissue Image Analysis13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models14. Biomarkers: Discovery, Qualification and Application15. Toxicogenomics: A Primer for Toxicologic Pathologists16. Experimental Design and Statistical Analysis for Toxicologic PathologistsPart 3 Animal and Alternative Models in Toxicologic Research17. Animal Models in Toxicologic Research: Rodents18. Animal Models in Toxicologic Research: Rabbit19. Animal Models in Toxicologic Research: Dog20. Animal Models in Toxicologic Research: Pig21. Animal Models in Toxicologic Research: Nonhuman Primate22. Animal Models in Toxicologic Research: Non-mammalian23. Genetically Engineered Animal Models in Toxicologic Research24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Non-Traditional In Vivo ApproachesPart 4 Practice of Toxicologic Pathology25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology26. Pathology Peer Review27. Pathology and GLPs, Quality Control and Quality Assurance28. Practices to Optimize Generation, Interpretation, And Reporting of Pathology Data from Toxicity Studies 29. Issues in Laboratory Animal Science that Impact Toxicologic Pathology

Wanda M. Haschek-Hock, BVSc, Ph.D., is a Diplomate of the American College of Veterinary Pathologists (DACVP), Fellow of the International Academy of Toxicologic Pathology (FIATP), and Honorary Member of the Latin American Society of Toxicologic Pathology. She is Professor Emerita at the University of Illinois College of Veterinary Medicine, Department of Pathobiology. Wanda has over 40 years of experience in comparative, respiratory, and toxicologic pathology with a research focus on natural toxins and food safety. She is a former President of the Society of Toxicologic Pathology (STP) and of the Society of Toxicology’s (SOT) Comparative and Veterinary Specialty Section and has served as an Associate Editor for Toxicological Sciences and Toxicologic Pathology, as Councilor of the American College of Veterinary Pathologists (ACVP), and as Member of the American Board of Toxicology (ABT). She served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. She is a recipient of the STP’s Lifetime Achievement Award, the SOT Midwest Regional Chapter’s Kenneth DuBois Award, and the University of Sydney Faculty of Veterinary Science Alumni Award for International Achievement in 2016. Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

*5 stars* "…the single leading reference on the practices of toxicologic pathology in areas of basic principles, laboratory safety and assessment, and organ-specific toxicity [that] strives to have the most up-to-date and innovative advances in one resource…. [A] convenient, all-in-one resource covering most, if not all, aspects of toxicologic pathology,… an essential resource that is tailored to be utilized at all levels of training and experience, making this book an invaluable investment that one would use throughout their career. This new edition has been expanded to include the vast number of advances that have occurred over the past five years since its last edition, making this the most reliable and up-to-date resource in toxicologic pathology today. The illustrations and photos are clear and serve to reinforce concepts as well as noteworthy characteristics. Every individual in the toxicology field, whether by industry, practice, or training, should have this book as a reference they will use for a lifetime." --©Doody’s Review Service, 2023, Isabella Marie Dishong, DO (University of Michigan Medical School)

• 1. Toxicology Pathology: An IntroductionPart 1 Principles of Toxicologic Pathology2. Biochemical and Molecular Basis of Toxicity3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective4. Biotherapeutic ADME and PK/PD Principles5. Principles of Pharmacodynamics and Toxicodynamics6. Morphologic Manifestations of Toxic Cell Injury7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity8. Carcinogenesis: Mechanisms and EvaluationPart 2 Methods in Toxicologic Pathology9. Basic Approaches to Anatomic Toxicologic Pathology10. Clinical Pathology in Nonclinical Toxicity Testing11. Special Techniques in Toxicologic Pathology12. Digital Pathology and Tissue Image Analysis13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models14. Biomarkers: Discovery, Qualification and Application15. Toxicogenomics: A Primer for Toxicologic Pathologists16. Experimental Design and Statistical Analysis for Toxicologic PathologistsPart 3 Animal and Alternative Models in Toxicologic Research17. Animal Models in Toxicologic Research: Rodents18. Animal Models in Toxicologic Research: Rabbit19. Animal Models in Toxicologic Research: Dog20. Animal Models in Toxicologic Research: Pig21. Animal Models in Toxicologic Research: Nonhuman Primate22. Animal Models in Toxicologic Research: Non-mammalian23. Genetically Engineered Animal Models in Toxicologic Research24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Non-Traditional In Vivo ApproachesPart 4 Practice of Toxicologic Pathology25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology26. Pathology Peer Review27. Pathology and GLPs, Quality Control and Quality Assurance28. Practices to Optimize Generation, Interpretation, And Reporting of Pathology Data from Toxicity Studies 29. Issues in Laboratory Animal Science that Impact Toxicologic Pathology

Wanda M. Haschek-Hock, BVSc, Ph.D., is a Diplomate of the American College of Veterinary Pathologists (DACVP), Fellow of the International Academy of Toxicologic Pathology (FIATP), and Honorary Member of the Latin American Society of Toxicologic Pathology. She is Professor Emerita at the University of Illinois College of Veterinary Medicine, Department of Pathobiology. Wanda has over 40 years of experience in comparative, respiratory, and toxicologic pathology with a research focus on natural toxins and food safety. She is a former President of the Society of Toxicologic Pathology (STP) and of the Society of Toxicology’s (SOT) Comparative and Veterinary Specialty Section and has served as an Associate Editor for Toxicological Sciences and Toxicologic Pathology, as Councilor of the American College of Veterinary Pathologists (ACVP), and as Member of the American Board of Toxicology (ABT). She served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. She is a recipient of the STP’s Lifetime Achievement Award, the SOT Midwest Regional Chapter’s Kenneth DuBois Award, and the University of Sydney Faculty of Veterinary Science Alumni Award for International Achievement in 2016. Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

*5 stars* "…the single leading reference on the practices of toxicologic pathology in areas of basic principles, laboratory safety and assessment, and organ-specific toxicity [that] strives to have the most up-to-date and innovative advances in one resource…. [A] convenient, all-in-one resource covering most, if not all, aspects of toxicologic pathology,… an essential resource that is tailored to be utilized at all levels of training and experience, making this book an invaluable investment that one would use throughout their career. This new edition has been expanded to include the vast number of advances that have occurred over the past five years since its last edition, making this the most reliable and up-to-date resource in toxicologic pathology today. The illustrations and photos are clear and serve to reinforce concepts as well as noteworthy characteristics. Every individual in the toxicology field, whether by industry, practice, or training, should have this book as a reference they will use for a lifetime." --©Doody’s Review Service, 2023, Isabella Marie Dishong, DO (University of Michigan Medical School)

• 1. Toxicology Pathology: An IntroductionPart 1 Principles of Toxicologic Pathology2. Biochemical and Molecular Basis of Toxicity3. ADME Principles in Small Molecule Drug Discovery and Development: An Industrial Perspective4. Biotherapeutic ADME and PK/PD Principles5. Principles of Pharmacodynamics and Toxicodynamics6. Morphologic Manifestations of Toxic Cell Injury7. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity8. Carcinogenesis: Mechanisms and EvaluationPart 2 Methods in Toxicologic Pathology9. Basic Approaches to Anatomic Toxicologic Pathology10. Clinical Pathology in Nonclinical Toxicity Testing11. Special Techniques in Toxicologic Pathology12. Digital Pathology and Tissue Image Analysis13. In Vivo Small Animal Imaging: A Comparison to Gross and Histopathologic Observations in Animal Models14. Biomarkers: Discovery, Qualification and Application15. Toxicogenomics: A Primer for Toxicologic Pathologists16. Experimental Design and Statistical Analysis for Toxicologic PathologistsPart 3 Animal and Alternative Models in Toxicologic Research17. Animal Models in Toxicologic Research: Rodents18. Animal Models in Toxicologic Research: Rabbit19. Animal Models in Toxicologic Research: Dog20. Animal Models in Toxicologic Research: Pig21. Animal Models in Toxicologic Research: Nonhuman Primate22. Animal Models in Toxicologic Research: Non-mammalian23. Genetically Engineered Animal Models in Toxicologic Research24. Alternative Models in Biomedical Research: In Silico, In Vitro, Ex Vivo, and Non-Traditional In Vivo ApproachesPart 4 Practice of Toxicologic Pathology25. Nomenclature and Diagnostic Resources in Anatomic Toxicologic Pathology26. Pathology Peer Review27. Pathology and GLPs, Quality Control and Quality Assurance28. Practices to Optimize Generation, Interpretation, And Reporting of Pathology Data from Toxicity Studies 29. Issues in Laboratory Animal Science that Impact Toxicologic Pathology