Patrick Davey DM FRCP is a consultant cardiologist at Northampton General Hospital and former training program director General Medicine for the East Midlands. His subspecialty interests include nuclear cardiology and coronary intervention. He studied undergraduate medicine at Cambridge, clinical medicine at Oxford, undertook SHO jobs in Leicester, and then trained in cardiology at Papworth, and returned to Oxford for research, and as senior registrar and senior lecturer. He has been a consultant cardiologist at Northampton since 2000. He is the editor of a number of bestselling textbooks including Medicine at a Glance, ECG at a Glance, amongst others.David Sprigings qualified from Oxford University Medical School and trained in internal medicine and cardiology in Oxford and London. He was a consultant physician and cardiologist at Northampton General Hospital from 1993 to 2016. From 2017 he has been a locum consultant cardiologist at John Radcliffe Hospital Oxford. His interests include electronic diagnostic systems to support the generalist, value-based healthcare, and the integration of primary and secondary care in cardiology.

Serendipitously, I stumbled upon your brilliant tome and discovered a treasure. Your book is luminously clear, engaging and clinical relevant. How I wish I had a textbook like this when I was doing my general medicine training some time back!

• Part 1 The approach to the patient 1: Diagnostic reasoning 2: Dealing with uncertainty 3: Taking the history 4: The physical examination 5: The psychological examination 6: Confidentiality 7: Consent Part 2 Assessment of symptoms and presenting problems 8: Palpitation 9: Acute chest pain 10: Chronic chest pain 11: Hypotension 12: Acute breathlessness 13: Chronic breathlessness 14: Peripheral oedema 15: Murmur 16: Cough 17: Wheeze 18: Haemoptysis 19: Pleural effusion 20: Chylothorax 21: Difficulty swallowing 22: Haematemesis 23: Acute abdominal pain 24: Chronic abdominal pain 25: Dyspepsia 26: Abdominal mass 27: Constipation 28: Acute diarrhoea 29: Chronic diarrhoea 30: Rectal bleeding 31: Jaundice 32: Ascites 33: Chylous ascites 34: Swelling in the neck 35: Splenomegaly and other disorders of the spleen 36: Lymphadenopathy 37: Anaemia 38: Bruising and bleeding 39: Transient loss of consciousness 40: Coma 41: Delirium (Acute confusional state) 42: Seizures 43: Difficulty speaking (including dysphasia and dysarthria) 44: Weakness 45: Tremor and other abnormal movements 46: Gait disorders 47: Sensory loss 48: Headache 49: Loss of vision 50: The red eye 51: Hearing loss 52: Facial pain 53: Dizziness 54: Disorders of sleep 55: Haematuria 56: Oliguria and anuria 57: Polyuria 58: Dysuria 59: Urinary incontinence 60: Faecal incontinence 61: Vaginal discharge 62: Joint pain 63: Muscle pain 64: Low back pain 65: Painful leg 66: Leg ulcer 67: Limb ischaemia 68: Rashes 69: Blistering rashes 70: Photosensitive rashes 71: Itching 72: Lumps and bumps 73: Falls 74: Immobility ( Off legs ) 75: Suspected anaphylaxis 76: Fever 77: Hyperthermia 78: Hypothermia 79: Fatigue 80: Unintentional weight loss 81: Obesity 82: Self-harm 83: Alcohol intoxication 84: Intravenous drug use Part 3 Cardiovascular disorders 85: Normal function of the cardiovascular system 86: Risk factors for cardiovascular disease 87: Diagnosis and investigation in suspected heart disease 88: Congenital heart disease in adults 89: Chronic stable angina 90: Acute coronary syndromes 91: Acute heart failure 92: Chronic heart failure 93: Aortic stenosis 94: Aortic regurgitation 95: Mitral regurgitation 96: Miscellaneous valvar pathology: mitral stenosis, pulmonary stenosis, and tricuspid regurgitation 97: Percutaneous coronary interventions 98: Heart surgery 99: Circulatory support therapy 100: Pulmonary hypertension 101: Venous thrombosis and pulmonary embolism 102: Aortic aneurysm 103: Aortic dissection 104: Peripheral arterial disease 105: Raynaud's phenomenon 106: Heart muscle disease (cardiomyopathy) 107: Tumours and the heart 108: Cardiac infection 109: Pericardial disease 110: Extrasystoles 111: Sinus tachycardia 112: Focal (ectopic) atrial tachycardia (FAT/EAT) 113: Multifocal atrial tachycardia (MAT) 114: Atrioventricular nodal re-entrant tachycardia (AVNRT) 115: Atrioventricular re-entrant tachycardia (AVRT) 116: Atrial fibrillation 117: Atrial flutter 118: Ventricular tachyarrhythmias: ventricular tachycardia and ventricular fibrillation 119: Bradyarrhythmias 120: Sudden cardiac death 121: Cardiac device therapy 122: Drug-induced cardiovascular disease 123: Psychological management of coronary heart disease 124: Treatment of terminal cardiovascular disease Part 4 Respiratory disorders 125: Normal respiratory function 126: Diagnosis in suspected respiratory disease 127: Investigation in respiratory disease 128: Upper respiratory tract infection, including influenza 129: Pneumonia 130: Tuberculosis 131: Pneumothorax 132: Cystic fibrosis 133: Asthma 134: Chronic obstructive pulmonary disease 135: Respiratory failure 136: Obstructive sleep apnoea 137: Bronchiectasis 138: Sarcoidosis and other granulomatous lung disease 139: Interstitial lung disease 140: Pulmonary vasculitis 141: Lung cancer (including management of an isolated lung lesion) 142: Occupational lung disease 143: Pleural infection and malignancy 144: Drug-induced lung disease 145: Psychology in respiratory disease including dysfunctional breathing 146: Terminal care in respiratory illness Part 5 Intensive care medicine 147: Critical illness 148: Role of the intensive care unit 149: ICU treatment of respiratory failure 150: ICU treatment of cardiovascular failure 151: ICU treatment of renal failure 152: ICU treatment of sepsis and septic shock 153: Terminal care in the intensive care unit 154: Brain death Part 6 Disorders of the kidney and urinary tract 155: Normal renal function 156: Diagnosis in suspected renal disease 157: Investigation in renal disease 158: Urinary tract infection 159: Glomerulonephritis 160: Interstitial renal disease 161: Nephrotic syndrome 162: Acute renal failure 163: Chronic kidney disease 164: Diabetic renal disease 165: Urinary tract obstruction and tumours 166: Renal calculi 167: Renal and bladder cancer 168: Renal support therapy 169: Inherited renal diseases 170: The kidney in systemic disease 171: Renal vascular disease 172: Management of terminal care in renal disease 173: Disorders of plasma potassium 174: Disorders of plasma sodium 175: Disorders of plasma calcium 176: Disorders of plasma phosphate 177: Disorders of plasma magnesium and other elements 178: Disorders of acid-base balance 179: Porphyria 180: Aminoacidopathies, urea cycle disorders and organic acidurias 181: Amyloidosis Part 7 Diabetes mellitus and endocrine disorders 182: Normal function of the endocrine system 183: Diagnosis and investigation in endocrine disorders 184: Diabetes mellitus 185: Hypoglycaemia 186: Thyroid disease 187: Primary hyperparathyroidism 188: Adrenal disease 189: Cushing syndrome 190: Short stature 191: Infertility 192: Pituitary disorders: prolactinomas, acromegaly and pituitary apoplexy Part 8 Gastro-intestinal disorders 193: Normal gastrointestinal function 194: Diagnosis in suspected gastrointestinal disease 195: Investigation in gastrointestinal disease 196: Immunology and genetics in gastrointestinal and hepatic medicine 197: Gastrointestinal infections 198: Benign oesophageal disease 199: Peptic ulcer disease 200: Gall bladder disease 201: Pancreatic disease 202: Malabsorption 203: Inflammatory bowel disease 204: Gastrointestinal tumours 205: Functional gastrointestinal diseases 206: Psychiatry in gastrointestinal medicine Part 9 Disorders of the liver 207: Normal hepatic function 208: Investigation in liver disease 209: Acute liver failure 210: Chronic liver failure 211: Alcoholic liver disease 212: Viral hepatitis 213: Auto-immune hepatitis 214: Genetic liver disease 215: Drug-induced liver disease 216: Miscellaneous liver diseases 217: The liver in systemic disease 218: Liver cancer Part 10 Neurological disorders 219: Normal neurological function 220: Diagnosis in suspected neurological disease 221: Investigation in neurological disease 222: Demographics of neurological disease 223: Neurogenetic disease 224: Neuro-cutaneous syndromes 225: Congenital neurological disorders 226: Epilepsy 227: Stroke 228: Dementia 229: Neurological infection 230: Disorders of movement 231: Multiple sclerosis 232: Motor neurone disease 233: Spinal cord disease 234: Neuropathy 235: Myopathy 236: Vasculitis in neurology 237: Neurological tumours 238: Non-metastatic neurological manifestations of malignancy 239: Neurosurgery 240: Drug-induced neurological disease 241: Functional and dissociative neurological symptoms 242: Palliative care in neurological disease Part 11 Disorders of the skin 243: Normal skin function 244: Approach to diagnosing skin disease 245: Investigation in skin disease 246: Skin infection and infestation 247: Cutaneous vasculitis 248: Acne 249: Psoriasis 250: Eczema 251: Urticaria 252: Bullous disorders 253: Hair disorders 254: Nail disorders 255: Mucosal disease 256: Genital disease 257: Polymorphic light eruption and actinic prurigo 258: Disorders of pigmentation 259: Skin cancer 260: Skin markers of internal disease 261: Drug-induced skin disease 262: Psychocutaneous medicine Part 12 Disorders of the musculoskeletal system 263: Normal function of the musculoskeletal system 264: Diagnosis in suspected rheumatological disease 265: Investigation in rheumatological disease 266: Osteoarthritis 267: Rheumatoid arthritis 268: Sero-negative spondylarthropathy 269: Systemic lupus erythematosus 270: Crystal arthropathy 271: Infection of joints and bones 272: Vasculitis 273: Osteomalacia 274: Paget's disease of bone 275: Osteoporosis and fragility fracture 276: Genetic bone and joint disease Part 13 Haematological disorders 277: Normal blood function 278: Diagnosis and investigation in haematology 279: Haematinic-deficiency anaemia 280: Haemolytic anaemia 281: Normal platelet function 282: Platelet disorders 283: Normal haemostatic function 284: Bleeding disorders 285: Prothrombotic conditions 286: Acute leukaemia 287: Chronic leukaemia 288: Myelodysplasia 289: Lymphoma 290: Multiple myeloma and related conditions 291: Myeloproliferative disorders 292: Terminal care in haematological disease Part 14 Disorders of the immune system 293: Functions of the immune system 294: Clinical features and diagnosis of immunological disease 295: Neutrophil abnormalities 296: Human immunodeficiency virus (HIV) infection 297: Antibody deficiencies 298: Combined T and B cell immunodeficiencies 299: Complement deficiencies 300: Hypersensitivity diseases 301: Immunological support 302: Immunosuppressive therapy and therapeutic monoclonal antibodies Part 15 Infectious diseases 303: Defences against infection 304: Nature and demographics: Epidemiology of infective organisms 305: Diagnosis in suspected infective disease: The history and examination 306: Investigation in infection 307: Treatment of infection 308: Viral infection 309: Sepsis 310: Bacterial infection 311: Mycobacterial infection other than tuberculosis 312: Spirochaetal infection (non-syphilis) 313: Syphilis 314: Rickettsial infection 315: Fungal infection 316: Protozoal infection: Gut organisms 317: Protozoal infection: Malaria 318: Worm infection (including hydatid disease) 319: Prion disease 320: Sexually-transmitted disease (gonorrhoea) Part 16 Cancers 321: Cancers related to infection 322: Principles of oncogenesis 323: Presentations in suspected cancer 324: Diagnosis and staging of cancer 325: Treatment of cancer 326: Prostate cancer 327: Breast cancer 328: Ovarian and testicular cancer 329: Symptom-control in cancer 330: Dying from cancer Part 17 Dietary, lifestyle and environmental factors affecting health 331: Normal nutritional function 332: Starvation and malnutrition 333: Vitamin deficiencies 334: Nutritional support in the critically ill 335: Poor diets 336: Obesity 337: Physical activity and its role in disease prevention 338: Smoking 339: Alcohol 340: Environmental radiation 341: Air pollution 342: Non-prescription drugs Part 18 Prevention of disease 343: Prevention of cardiovascular disease 344: Prevention of respiratory disease 345: Prevention of kidney disease 346: Prevention of gastrointestinal disease 347: Prevention of neurological disease 348: Prevention of cerebrovascular disease 349: Prevention of infection 350: Prevention of cancer Part 19 Screening for disease 351: Screening for cardiovascular disease 352: Screening for respiratory disease 353: Screening for kidney disease 354: Screening for gastrointestinal disease 355: Screening for neurological disease 356: Screening for cancer

Patrick Davey DM FRCP is a consultant cardiologist at Northampton General Hospital and former training program director General Medicine for the East Midlands. His subspecialty interests include nuclear cardiology and coronary intervention. He studied undergraduate medicine at Cambridge, clinical medicine at Oxford, undertook SHO jobs in Leicester, and then trained in cardiology at Papworth, and returned to Oxford for research, and as senior registrar and senior lecturer. He has been a consultant cardiologist at Northampton since 2000. He is the editor of a number of bestselling textbooks including Medicine at a Glance, ECG at a Glance, amongst others.David Sprigings qualified from Oxford University Medical School and trained in internal medicine and cardiology in Oxford and London. He was a consultant physician and cardiologist at Northampton General Hospital from 1993 to 2016. From 2017 he has been a locum consultant cardiologist at John Radcliffe Hospital Oxford. His interests include electronic diagnostic systems to support the generalist, value-based healthcare, and the integration of primary and secondary care in cardiology.

Serendipitously, I stumbled upon your brilliant tome and discovered a treasure. Your book is luminously clear, engaging and clinical relevant. How I wish I had a textbook like this when I was doing my general medicine training some time back!

• Part 1 The approach to the patient 1: Diagnostic reasoning 2: Dealing with uncertainty 3: Taking the history 4: The physical examination 5: The psychological examination 6: Confidentiality 7: Consent Part 2 Assessment of symptoms and presenting problems 8: Palpitation 9: Acute chest pain 10: Chronic chest pain 11: Hypotension 12: Acute breathlessness 13: Chronic breathlessness 14: Peripheral oedema 15: Murmur 16: Cough 17: Wheeze 18: Haemoptysis 19: Pleural effusion 20: Chylothorax 21: Difficulty swallowing 22: Haematemesis 23: Acute abdominal pain 24: Chronic abdominal pain 25: Dyspepsia 26: Abdominal mass 27: Constipation 28: Acute diarrhoea 29: Chronic diarrhoea 30: Rectal bleeding 31: Jaundice 32: Ascites 33: Chylous ascites 34: Swelling in the neck 35: Splenomegaly and other disorders of the spleen 36: Lymphadenopathy 37: Anaemia 38: Bruising and bleeding 39: Transient loss of consciousness 40: Coma 41: Delirium (Acute confusional state) 42: Seizures 43: Difficulty speaking (including dysphasia and dysarthria) 44: Weakness 45: Tremor and other abnormal movements 46: Gait disorders 47: Sensory loss 48: Headache 49: Loss of vision 50: The red eye 51: Hearing loss 52: Facial pain 53: Dizziness 54: Disorders of sleep 55: Haematuria 56: Oliguria and anuria 57: Polyuria 58: Dysuria 59: Urinary incontinence 60: Faecal incontinence 61: Vaginal discharge 62: Joint pain 63: Muscle pain 64: Low back pain 65: Painful leg 66: Leg ulcer 67: Limb ischaemia 68: Rashes 69: Blistering rashes 70: Photosensitive rashes 71: Itching 72: Lumps and bumps 73: Falls 74: Immobility ( Off legs ) 75: Suspected anaphylaxis 76: Fever 77: Hyperthermia 78: Hypothermia 79: Fatigue 80: Unintentional weight loss 81: Obesity 82: Self-harm 83: Alcohol intoxication 84: Intravenous drug use Part 3 Cardiovascular disorders 85: Normal function of the cardiovascular system 86: Risk factors for cardiovascular disease 87: Diagnosis and investigation in suspected heart disease 88: Congenital heart disease in adults 89: Chronic stable angina 90: Acute coronary syndromes 91: Acute heart failure 92: Chronic heart failure 93: Aortic stenosis 94: Aortic regurgitation 95: Mitral regurgitation 96: Miscellaneous valvar pathology: mitral stenosis, pulmonary stenosis, and tricuspid regurgitation 97: Percutaneous coronary interventions 98: Heart surgery 99: Circulatory support therapy 100: Pulmonary hypertension 101: Venous thrombosis and pulmonary embolism 102: Aortic aneurysm 103: Aortic dissection 104: Peripheral arterial disease 105: Raynaud's phenomenon 106: Heart muscle disease (cardiomyopathy) 107: Tumours and the heart 108: Cardiac infection 109: Pericardial disease 110: Extrasystoles 111: Sinus tachycardia 112: Focal (ectopic) atrial tachycardia (FAT/EAT) 113: Multifocal atrial tachycardia (MAT) 114: Atrioventricular nodal re-entrant tachycardia (AVNRT) 115: Atrioventricular re-entrant tachycardia (AVRT) 116: Atrial fibrillation 117: Atrial flutter 118: Ventricular tachyarrhythmias: ventricular tachycardia and ventricular fibrillation 119: Bradyarrhythmias 120: Sudden cardiac death 121: Cardiac device therapy 122: Drug-induced cardiovascular disease 123: Psychological management of coronary heart disease 124: Treatment of terminal cardiovascular disease Part 4 Respiratory disorders 125: Normal respiratory function 126: Diagnosis in suspected respiratory disease 127: Investigation in respiratory disease 128: Upper respiratory tract infection, including influenza 129: Pneumonia 130: Tuberculosis 131: Pneumothorax 132: Cystic fibrosis 133: Asthma 134: Chronic obstructive pulmonary disease 135: Respiratory failure 136: Obstructive sleep apnoea 137: Bronchiectasis 138: Sarcoidosis and other granulomatous lung disease 139: Interstitial lung disease 140: Pulmonary vasculitis 141: Lung cancer (including management of an isolated lung lesion) 142: Occupational lung disease 143: Pleural infection and malignancy 144: Drug-induced lung disease 145: Psychology in respiratory disease including dysfunctional breathing 146: Terminal care in respiratory illness Part 5 Intensive care medicine 147: Critical illness 148: Role of the intensive care unit 149: ICU treatment of respiratory failure 150: ICU treatment of cardiovascular failure 151: ICU treatment of renal failure 152: ICU treatment of sepsis and septic shock 153: Terminal care in the intensive care unit 154: Brain death Part 6 Disorders of the kidney and urinary tract 155: Normal renal function 156: Diagnosis in suspected renal disease 157: Investigation in renal disease 158: Urinary tract infection 159: Glomerulonephritis 160: Interstitial renal disease 161: Nephrotic syndrome 162: Acute renal failure 163: Chronic kidney disease 164: Diabetic renal disease 165: Urinary tract obstruction and tumours 166: Renal calculi 167: Renal and bladder cancer 168: Renal support therapy 169: Inherited renal diseases 170: The kidney in systemic disease 171: Renal vascular disease 172: Management of terminal care in renal disease 173: Disorders of plasma potassium 174: Disorders of plasma sodium 175: Disorders of plasma calcium 176: Disorders of plasma phosphate 177: Disorders of plasma magnesium and other elements 178: Disorders of acid-base balance 179: Porphyria 180: Aminoacidopathies, urea cycle disorders and organic acidurias 181: Amyloidosis Part 7 Diabetes mellitus and endocrine disorders 182: Normal function of the endocrine system 183: Diagnosis and investigation in endocrine disorders 184: Diabetes mellitus 185: Hypoglycaemia 186: Thyroid disease 187: Primary hyperparathyroidism 188: Adrenal disease 189: Cushing syndrome 190: Short stature 191: Infertility 192: Pituitary disorders: prolactinomas, acromegaly and pituitary apoplexy Part 8 Gastro-intestinal disorders 193: Normal gastrointestinal function 194: Diagnosis in suspected gastrointestinal disease 195: Investigation in gastrointestinal disease 196: Immunology and genetics in gastrointestinal and hepatic medicine 197: Gastrointestinal infections 198: Benign oesophageal disease 199: Peptic ulcer disease 200: Gall bladder disease 201: Pancreatic disease 202: Malabsorption 203: Inflammatory bowel disease 204: Gastrointestinal tumours 205: Functional gastrointestinal diseases 206: Psychiatry in gastrointestinal medicine Part 9 Disorders of the liver 207: Normal hepatic function 208: Investigation in liver disease 209: Acute liver failure 210: Chronic liver failure 211: Alcoholic liver disease 212: Viral hepatitis 213: Auto-immune hepatitis 214: Genetic liver disease 215: Drug-induced liver disease 216: Miscellaneous liver diseases 217: The liver in systemic disease 218: Liver cancer Part 10 Neurological disorders 219: Normal neurological function 220: Diagnosis in suspected neurological disease 221: Investigation in neurological disease 222: Demographics of neurological disease 223: Neurogenetic disease 224: Neuro-cutaneous syndromes 225: Congenital neurological disorders 226: Epilepsy 227: Stroke 228: Dementia 229: Neurological infection 230: Disorders of movement 231: Multiple sclerosis 232: Motor neurone disease 233: Spinal cord disease 234: Neuropathy 235: Myopathy 236: Vasculitis in neurology 237: Neurological tumours 238: Non-metastatic neurological manifestations of malignancy 239: Neurosurgery 240: Drug-induced neurological disease 241: Functional and dissociative neurological symptoms 242: Palliative care in neurological disease Part 11 Disorders of the skin 243: Normal skin function 244: Approach to diagnosing skin disease 245: Investigation in skin disease 246: Skin infection and infestation 247: Cutaneous vasculitis 248: Acne 249: Psoriasis 250: Eczema 251: Urticaria 252: Bullous disorders 253: Hair disorders 254: Nail disorders 255: Mucosal disease 256: Genital disease 257: Polymorphic light eruption and actinic prurigo 258: Disorders of pigmentation 259: Skin cancer 260: Skin markers of internal disease 261: Drug-induced skin disease 262: Psychocutaneous medicine Part 12 Disorders of the musculoskeletal system 263: Normal function of the musculoskeletal system 264: Diagnosis in suspected rheumatological disease 265: Investigation in rheumatological disease 266: Osteoarthritis 267: Rheumatoid arthritis 268: Sero-negative spondylarthropathy 269: Systemic lupus erythematosus 270: Crystal arthropathy 271: Infection of joints and bones 272: Vasculitis 273: Osteomalacia 274: Paget's disease of bone 275: Osteoporosis and fragility fracture 276: Genetic bone and joint disease Part 13 Haematological disorders 277: Normal blood function 278: Diagnosis and investigation in haematology 279: Haematinic-deficiency anaemia 280: Haemolytic anaemia 281: Normal platelet function 282: Platelet disorders 283: Normal haemostatic function 284: Bleeding disorders 285: Prothrombotic conditions 286: Acute leukaemia 287: Chronic leukaemia 288: Myelodysplasia 289: Lymphoma 290: Multiple myeloma and related conditions 291: Myeloproliferative disorders 292: Terminal care in haematological disease Part 14 Disorders of the immune system 293: Functions of the immune system 294: Clinical features and diagnosis of immunological disease 295: Neutrophil abnormalities 296: Human immunodeficiency virus (HIV) infection 297: Antibody deficiencies 298: Combined T and B cell immunodeficiencies 299: Complement deficiencies 300: Hypersensitivity diseases 301: Immunological support 302: Immunosuppressive therapy and therapeutic monoclonal antibodies Part 15 Infectious diseases 303: Defences against infection 304: Nature and demographics: Epidemiology of infective organisms 305: Diagnosis in suspected infective disease: The history and examination 306: Investigation in infection 307: Treatment of infection 308: Viral infection 309: Sepsis 310: Bacterial infection 311: Mycobacterial infection other than tuberculosis 312: Spirochaetal infection (non-syphilis) 313: Syphilis 314: Rickettsial infection 315: Fungal infection 316: Protozoal infection: Gut organisms 317: Protozoal infection: Malaria 318: Worm infection (including hydatid disease) 319: Prion disease 320: Sexually-transmitted disease (gonorrhoea) Part 16 Cancers 321: Cancers related to infection 322: Principles of oncogenesis 323: Presentations in suspected cancer 324: Diagnosis and staging of cancer 325: Treatment of cancer 326: Prostate cancer 327: Breast cancer 328: Ovarian and testicular cancer 329: Symptom-control in cancer 330: Dying from cancer Part 17 Dietary, lifestyle and environmental factors affecting health 331: Normal nutritional function 332: Starvation and malnutrition 333: Vitamin deficiencies 334: Nutritional support in the critically ill 335: Poor diets 336: Obesity 337: Physical activity and its role in disease prevention 338: Smoking 339: Alcohol 340: Environmental radiation 341: Air pollution 342: Non-prescription drugs Part 18 Prevention of disease 343: Prevention of cardiovascular disease 344: Prevention of respiratory disease 345: Prevention of kidney disease 346: Prevention of gastrointestinal disease 347: Prevention of neurological disease 348: Prevention of cerebrovascular disease 349: Prevention of infection 350: Prevention of cancer Part 19 Screening for disease 351: Screening for cardiovascular disease 352: Screening for respiratory disease 353: Screening for kidney disease 354: Screening for gastrointestinal disease 355: Screening for neurological disease 356: Screening for cancer

Patrick Davey DM FRCP is a consultant cardiologist at Northampton General Hospital and former training program director General Medicine for the East Midlands. His subspecialty interests include nuclear cardiology and coronary intervention. He studied undergraduate medicine at Cambridge, clinical medicine at Oxford, undertook SHO jobs in Leicester, and then trained in cardiology at Papworth, and returned to Oxford for research, and as senior registrar and senior lecturer. He has been a consultant cardiologist at Northampton since 2000. He is the editor of a number of bestselling textbooks including Medicine at a Glance, ECG at a Glance, amongst others.David Sprigings qualified from Oxford University Medical School and trained in internal medicine and cardiology in Oxford and London. He was a consultant physician and cardiologist at Northampton General Hospital from 1993 to 2016. From 2017 he has been a locum consultant cardiologist at John Radcliffe Hospital Oxford. His interests include electronic diagnostic systems to support the generalist, value-based healthcare, and the integration of primary and secondary care in cardiology.

Serendipitously, I stumbled upon your brilliant tome and discovered a treasure. Your book is luminously clear, engaging and clinical relevant. How I wish I had a textbook like this when I was doing my general medicine training some time back!

• Part 1 The approach to the patient 1: Diagnostic reasoning 2: Dealing with uncertainty 3: Taking the history 4: The physical examination 5: The psychological examination 6: Confidentiality 7: Consent Part 2 Assessment of symptoms and presenting problems 8: Palpitation 9: Acute chest pain 10: Chronic chest pain 11: Hypotension 12: Acute breathlessness 13: Chronic breathlessness 14: Peripheral oedema 15: Murmur 16: Cough 17: Wheeze 18: Haemoptysis 19: Pleural effusion 20: Chylothorax 21: Difficulty swallowing 22: Haematemesis 23: Acute abdominal pain 24: Chronic abdominal pain 25: Dyspepsia 26: Abdominal mass 27: Constipation 28: Acute diarrhoea 29: Chronic diarrhoea 30: Rectal bleeding 31: Jaundice 32: Ascites 33: Chylous ascites 34: Swelling in the neck 35: Splenomegaly and other disorders of the spleen 36: Lymphadenopathy 37: Anaemia 38: Bruising and bleeding 39: Transient loss of consciousness 40: Coma 41: Delirium (Acute confusional state) 42: Seizures 43: Difficulty speaking (including dysphasia and dysarthria) 44: Weakness 45: Tremor and other abnormal movements 46: Gait disorders 47: Sensory loss 48: Headache 49: Loss of vision 50: The red eye 51: Hearing loss 52: Facial pain 53: Dizziness 54: Disorders of sleep 55: Haematuria 56: Oliguria and anuria 57: Polyuria 58: Dysuria 59: Urinary incontinence 60: Faecal incontinence 61: Vaginal discharge 62: Joint pain 63: Muscle pain 64: Low back pain 65: Painful leg 66: Leg ulcer 67: Limb ischaemia 68: Rashes 69: Blistering rashes 70: Photosensitive rashes 71: Itching 72: Lumps and bumps 73: Falls 74: Immobility ( Off legs ) 75: Suspected anaphylaxis 76: Fever 77: Hyperthermia 78: Hypothermia 79: Fatigue 80: Unintentional weight loss 81: Obesity 82: Self-harm 83: Alcohol intoxication 84: Intravenous drug use Part 3 Cardiovascular disorders 85: Normal function of the cardiovascular system 86: Risk factors for cardiovascular disease 87: Diagnosis and investigation in suspected heart disease 88: Congenital heart disease in adults 89: Chronic stable angina 90: Acute coronary syndromes 91: Acute heart failure 92: Chronic heart failure 93: Aortic stenosis 94: Aortic regurgitation 95: Mitral regurgitation 96: Miscellaneous valvar pathology: mitral stenosis, pulmonary stenosis, and tricuspid regurgitation 97: Percutaneous coronary interventions 98: Heart surgery 99: Circulatory support therapy 100: Pulmonary hypertension 101: Venous thrombosis and pulmonary embolism 102: Aortic aneurysm 103: Aortic dissection 104: Peripheral arterial disease 105: Raynaud's phenomenon 106: Heart muscle disease (cardiomyopathy) 107: Tumours and the heart 108: Cardiac infection 109: Pericardial disease 110: Extrasystoles 111: Sinus tachycardia 112: Focal (ectopic) atrial tachycardia (FAT/EAT) 113: Multifocal atrial tachycardia (MAT) 114: Atrioventricular nodal re-entrant tachycardia (AVNRT) 115: Atrioventricular re-entrant tachycardia (AVRT) 116: Atrial fibrillation 117: Atrial flutter 118: Ventricular tachyarrhythmias: ventricular tachycardia and ventricular fibrillation 119: Bradyarrhythmias 120: Sudden cardiac death 121: Cardiac device therapy 122: Drug-induced cardiovascular disease 123: Psychological management of coronary heart disease 124: Treatment of terminal cardiovascular disease Part 4 Respiratory disorders 125: Normal respiratory function 126: Diagnosis in suspected respiratory disease 127: Investigation in respiratory disease 128: Upper respiratory tract infection, including influenza 129: Pneumonia 130: Tuberculosis 131: Pneumothorax 132: Cystic fibrosis 133: Asthma 134: Chronic obstructive pulmonary disease 135: Respiratory failure 136: Obstructive sleep apnoea 137: Bronchiectasis 138: Sarcoidosis and other granulomatous lung disease 139: Interstitial lung disease 140: Pulmonary vasculitis 141: Lung cancer (including management of an isolated lung lesion) 142: Occupational lung disease 143: Pleural infection and malignancy 144: Drug-induced lung disease 145: Psychology in respiratory disease including dysfunctional breathing 146: Terminal care in respiratory illness Part 5 Intensive care medicine 147: Critical illness 148: Role of the intensive care unit 149: ICU treatment of respiratory failure 150: ICU treatment of cardiovascular failure 151: ICU treatment of renal failure 152: ICU treatment of sepsis and septic shock 153: Terminal care in the intensive care unit 154: Brain death Part 6 Disorders of the kidney and urinary tract 155: Normal renal function 156: Diagnosis in suspected renal disease 157: Investigation in renal disease 158: Urinary tract infection 159: Glomerulonephritis 160: Interstitial renal disease 161: Nephrotic syndrome 162: Acute renal failure 163: Chronic kidney disease 164: Diabetic renal disease 165: Urinary tract obstruction and tumours 166: Renal calculi 167: Renal and bladder cancer 168: Renal support therapy 169: Inherited renal diseases 170: The kidney in systemic disease 171: Renal vascular disease 172: Management of terminal care in renal disease 173: Disorders of plasma potassium 174: Disorders of plasma sodium 175: Disorders of plasma calcium 176: Disorders of plasma phosphate 177: Disorders of plasma magnesium and other elements 178: Disorders of acid-base balance 179: Porphyria 180: Aminoacidopathies, urea cycle disorders and organic acidurias 181: Amyloidosis Part 7 Diabetes mellitus and endocrine disorders 182: Normal function of the endocrine system 183: Diagnosis and investigation in endocrine disorders 184: Diabetes mellitus 185: Hypoglycaemia 186: Thyroid disease 187: Primary hyperparathyroidism 188: Adrenal disease 189: Cushing syndrome 190: Short stature 191: Infertility 192: Pituitary disorders: prolactinomas, acromegaly and pituitary apoplexy Part 8 Gastro-intestinal disorders 193: Normal gastrointestinal function 194: Diagnosis in suspected gastrointestinal disease 195: Investigation in gastrointestinal disease 196: Immunology and genetics in gastrointestinal and hepatic medicine 197: Gastrointestinal infections 198: Benign oesophageal disease 199: Peptic ulcer disease 200: Gall bladder disease 201: Pancreatic disease 202: Malabsorption 203: Inflammatory bowel disease 204: Gastrointestinal tumours 205: Functional gastrointestinal diseases 206: Psychiatry in gastrointestinal medicine Part 9 Disorders of the liver 207: Normal hepatic function 208: Investigation in liver disease 209: Acute liver failure 210: Chronic liver failure 211: Alcoholic liver disease 212: Viral hepatitis 213: Auto-immune hepatitis 214: Genetic liver disease 215: Drug-induced liver disease 216: Miscellaneous liver diseases 217: The liver in systemic disease 218: Liver cancer Part 10 Neurological disorders 219: Normal neurological function 220: Diagnosis in suspected neurological disease 221: Investigation in neurological disease 222: Demographics of neurological disease 223: Neurogenetic disease 224: Neuro-cutaneous syndromes 225: Congenital neurological disorders 226: Epilepsy 227: Stroke 228: Dementia 229: Neurological infection 230: Disorders of movement 231: Multiple sclerosis 232: Motor neurone disease 233: Spinal cord disease 234: Neuropathy 235: Myopathy 236: Vasculitis in neurology 237: Neurological tumours 238: Non-metastatic neurological manifestations of malignancy 239: Neurosurgery 240: Drug-induced neurological disease 241: Functional and dissociative neurological symptoms 242: Palliative care in neurological disease Part 11 Disorders of the skin 243: Normal skin function 244: Approach to diagnosing skin disease 245: Investigation in skin disease 246: Skin infection and infestation 247: Cutaneous vasculitis 248: Acne 249: Psoriasis 250: Eczema 251: Urticaria 252: Bullous disorders 253: Hair disorders 254: Nail disorders 255: Mucosal disease 256: Genital disease 257: Polymorphic light eruption and actinic prurigo 258: Disorders of pigmentation 259: Skin cancer 260: Skin markers of internal disease 261: Drug-induced skin disease 262: Psychocutaneous medicine Part 12 Disorders of the musculoskeletal system 263: Normal function of the musculoskeletal system 264: Diagnosis in suspected rheumatological disease 265: Investigation in rheumatological disease 266: Osteoarthritis 267: Rheumatoid arthritis 268: Sero-negative spondylarthropathy 269: Systemic lupus erythematosus 270: Crystal arthropathy 271: Infection of joints and bones 272: Vasculitis 273: Osteomalacia 274: Paget's disease of bone 275: Osteoporosis and fragility fracture 276: Genetic bone and joint disease Part 13 Haematological disorders 277: Normal blood function 278: Diagnosis and investigation in haematology 279: Haematinic-deficiency anaemia 280: Haemolytic anaemia 281: Normal platelet function 282: Platelet disorders 283: Normal haemostatic function 284: Bleeding disorders 285: Prothrombotic conditions 286: Acute leukaemia 287: Chronic leukaemia 288: Myelodysplasia 289: Lymphoma 290: Multiple myeloma and related conditions 291: Myeloproliferative disorders 292: Terminal care in haematological disease Part 14 Disorders of the immune system 293: Functions of the immune system 294: Clinical features and diagnosis of immunological disease 295: Neutrophil abnormalities 296: Human immunodeficiency virus (HIV) infection 297: Antibody deficiencies 298: Combined T and B cell immunodeficiencies 299: Complement deficiencies 300: Hypersensitivity diseases 301: Immunological support 302: Immunosuppressive therapy and therapeutic monoclonal antibodies Part 15 Infectious diseases 303: Defences against infection 304: Nature and demographics: Epidemiology of infective organisms 305: Diagnosis in suspected infective disease: The history and examination 306: Investigation in infection 307: Treatment of infection 308: Viral infection 309: Sepsis 310: Bacterial infection 311: Mycobacterial infection other than tuberculosis 312: Spirochaetal infection (non-syphilis) 313: Syphilis 314: Rickettsial infection 315: Fungal infection 316: Protozoal infection: Gut organisms 317: Protozoal infection: Malaria 318: Worm infection (including hydatid disease) 319: Prion disease 320: Sexually-transmitted disease (gonorrhoea) Part 16 Cancers 321: Cancers related to infection 322: Principles of oncogenesis 323: Presentations in suspected cancer 324: Diagnosis and staging of cancer 325: Treatment of cancer 326: Prostate cancer 327: Breast cancer 328: Ovarian and testicular cancer 329: Symptom-control in cancer 330: Dying from cancer Part 17 Dietary, lifestyle and environmental factors affecting health 331: Normal nutritional function 332: Starvation and malnutrition 333: Vitamin deficiencies 334: Nutritional support in the critically ill 335: Poor diets 336: Obesity 337: Physical activity and its role in disease prevention 338: Smoking 339: Alcohol 340: Environmental radiation 341: Air pollution 342: Non-prescription drugs Part 18 Prevention of disease 343: Prevention of cardiovascular disease 344: Prevention of respiratory disease 345: Prevention of kidney disease 346: Prevention of gastrointestinal disease 347: Prevention of neurological disease 348: Prevention of cerebrovascular disease 349: Prevention of infection 350: Prevention of cancer Part 19 Screening for disease 351: Screening for cardiovascular disease 352: Screening for respiratory disease 353: Screening for kidney disease 354: Screening for gastrointestinal disease 355: Screening for neurological disease 356: Screening for cancer