This issue of Otolaryngologic Clinics, guest edited by Drs. Jean Anderson Eloy,� James K. Liu, and Michael Setzen, is devoted to Sinonasal and Ventral Skull Base Malignancies. Articles in this outstanding issue include: Overview of Sinonasal and Ventral Skull Base Malignancy Management; Evaluation of Patients with Sinonasal and Ventral Skull Base Malignancies; Anatomical Consideration in Sinonasal and Ventral Skull Base Malignancy Surgery; Staging of Sinonasal and Ventral Skull Base Malignancies; Endoscopic Resection of Sinonasal and Ventral Skull Base Malignancies; Transfacial and Craniofacial Approaches for Resection of Sinonasal and Ventral Skull Base Malignancies; Endoscopic Resection of Pterygopalatine Fossa and Infratemporal Fossa Malignancies; Endoscopic Resection of Clival Malignancies; Combined Endoscopic and open Approaches in the Management of Sinonasal and Ventral Skull Base Malignancies; Management of Orbital Involvement in Sinonasal and Ventral Skull Base Malignancies; Management of Cavernous Sinus Involvement in Sinonasal and Ventral Skull Base Malignancies; The Role of Robotic Surgery in the Management of Sinonasal and Ventral Skull Base Malignancies; Management of Skull Base Defects after Surgical Resection of Sinonasal and Ventral Skull Base Malignancies; The role of Radiation Therapy in the Management of Sinonasal and Ventral Skull Base Malignancies; The Role of Chemotherapy in the Management of Sinonasal and Ventral Skull Base Malignancies; The Role of Targeted Therapy in the Management of Sinonasal and Ventral Skull Base Malignancies; The Making of a Skull Base Team and the Value of Multidisciplinary Approach in the Management of Sinonasal and Ventral Skull Base Malignancies; Outcomes of Sinonasal and Ventral Skull Base Malignancy Management; and Population-Based Results in the Management of Sinonasal and Ventral Skull Base Malignancies.