Principles and Practice of Pediatric Infectious Diseases

Sarah S. Long is Professor of pediatrics at Drexel University College of Medicine. Dr. Long is an associate editor of The Journal of Pediatrics, as well as the Red Book Report of the Committee on Infectious Diseases of the American Academy of Pediatrics. She has chaired the program committee for annual meetings of the American Academy of Pediatrics, the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society. She sits on research advisory committees for the National Institutes of Health and the Centers for Disease Control and Prevention. Dr. Marc Fischer is a pediatric infectious disease specialist in Fort Collins, Colorado. He received his medical degree from Duke University School of Medicine and has been in practice for more than 20 years. David Kimberlin, MD is Professor/Co-Director, Division of Pediatric Infectious Diseases/Sergio B. Stagno, MD Endowed Chair in Pedaitric Infectious Diseases/Vice Chair for Clinical and Translational Research at Children's Alabama, Birmingham. Dr. Kimberlin is a world renowned pediatric infectious diseases specialist at the University of Alabama, is at the fulcrum of NIH- sponsored multicentered clinical trials especially related to antiviral therapy, is the chief editor of the Red Book Report of the Committee on Infectious Diseases of the American Academy of Pediatrics, and a national leader in academic and subspecilty societies. He has been a contributor of critical chapters in PPPID since its inception.

Doody's Core Titles® 2022"As a pediatric infectious disease clinician, I find this book to be a helpful reference for both clinical work as well as lecture preparation when engaging learners." --©Doody’s Review Service, 2022, Bradford Becken, MD (University of Nebraska Medical Center)

• PART I: Understanding, Controlling, and Preventing Infectious DiseasesSection A. Epidemiology and Control of Infectious Diseases1. Principles of Epidemiology and Public Health2. Pediatric Healthcare: Infection Epidemiology, Prevention and Control, and Antimicrobial Stewardship3. Infections Associated With Group Childcare4. Infectious Diseases in Refugee and Internationally Adopted ChildrenSection B. Prevention of Infectious Diseases5. Passive Immunization6. Active Immunization7. Antimicrobial Chemoprophylaxis8. Protection of TravelersSection C. Host Defenses Against Infectious Diseases9. Immunologic Development and Susceptibility to Infection10. Fever and the Inflammatory ResponsePART II: Clinical Syndromes and Cardinal Features of Infectious Diseases: Approach to Diagnosis and Initial ManagementSection A. Septicemia, Toxin-, and Inflammation-Mediated Syndromes11. The Systemic Inflammatory Response Syndrome, Sepsis, and Septic Shock12. Hemophagocytic Lymphohistiocytosis and Macrophage Activation SyndromeSection B. Cardinal Symptom Complexes13. Mucocutaneous Symptom Complexes14. Fever Without Localizing Signs15. Prolonged, Recurrent, and Periodic Fever Syndromes16. Lymphatic System and Generalized Lymphadenopathy17. Cervical Lymphadenitis and Neck Infections18. Mediastinal and Hilar Lymphadenopathy19. Abdominal and Retroperitoneal Lymphadenopathy20. Localized Lymphadenitis, Lymphadenopathy, and Lymphangitis21. Respiratory Tract Symptom Complexes22. Abdominal Symptom Complexes23. Neurologic Syndromes24. Musculoskeletal Symptom ComplexesSection C. Oral Infections and Upper and Middle Respiratory Tract Infections25. Infections of the Oral Cavity26. The Common Cold27. Pharyngitis28. Infections Related to the Upper and Middle Airways29. Otitis Media30. Otitis Externa and Necrotizing Otitis Externa31. Mastoiditis32. SinusitisSection D. Lower Respiratory Tract Infections33. Bronchiolitis34. Acute Pneumonia and Its Complications35. Persistent and Recurrent Pneumonia36. Pneumonia in the Immunocompromised HostSection E. Cardiac and Vascular Infections37. Endocarditis and Other Intravascular Infections38. Myocarditis39. PericarditisSection F. Central Nervous System Infections40. Acute Bacterial Meningitis Beyond the Neonatal Period41. Chronic Meningitis42. Recurrent Meningitis43. Aseptic and Viral Meningitis44. Encephalitis45. Parainfectious and Postinfectious Neurologic Syndromes46. Focal Suppurative Infections of the Nervous System47. Eosinophilic MeningitisSection G. Genitourinary Tract Infections48. Urinary Tract Infections, Renal Abscess, and Other Complex Renal Functions49. Sexually Transmitted Infection Syndromes50. Genitourinary Skin and Mucous Membrane Infections and Inguinal Lymphadenopathy51. Urethritis, Vulvovaginitis, and Cervicitis52. Pelvic Inflammatory Disease53. Epididymitis, Orchitis, and Prostatitis54. Infectious Diseases Associated With Child AbuseSection H. Gastrointestinal and Tract Infections and Intoxications55. Approach to the Diagnosis and Management of Gastrointestinal Tract Infections56. Viral Gastroenteritis57. Inflammatory Enterocolitis58. Enteric Diseases Transmitted Through Food, Water, and Zoonotic ExposuresSection I. Intra-abdominal Infections59. Acute Hepatitis60. Chronic Hepatitis61. Granulomatous Hepatitis62. Acute Pancreatitis63. Cholecystitis and Cholangitis64. Peritonitis65. Appendicitis66. Intra-abdominal, Visceral, and Retroperitoneal AbscessesSection J. Skin and Soft-Tissue Infections67. Superficial Bacterial Skin Infections and Cellulitis68. Erythematous Macules and Papules69. Vesicles and Bullae70. Purpura71. Urticaria and Erythema Multiforme72. Papules, Nodules, and Ulcers73. Subcutaneous Tissue Infections and Abscesses74. Myositis, Pyomyositis, and Necrotizing FascitisSection K. Bone and Joint Infections75. Osteomyelitis76. Infectious and Inflammatory Arthritis77. Diskitis78. Transient SynovitisSection L. Eye Infections79. Conjunctivitis in the Neonatal Period (Ophthalmia neonatorum)80. Conjunctivitis Beyond the Neonatal Period81. Infective Keratitis82. Infective Uveitis, Retinitis, and Chorioretinitis83. Endophthalmitis84. Preseptal and Orbital InfectionsSection M. Infections Related to Trauma, Animals, and Ticks85. Infection Related To Trauma86. Infections Related to Burns87. Infection Related To Bites88. Infections Related to Pets and Exotic Animals89. Tickborne InfectionsSection N. Infections of the Fetus and Newborn90. Clinical Approach to the Neonate With Suspected Infection91. Chorioamnionitis and Neonatal Consequences92. Bacterial Infections in the Neonate93. Viral Infections in the Fetus and Neonate94. Healthcare-Associated Infections in the NeonateSection O. Infections and Transplantation95. Infections in Solid Organ Transplant Recipients96. Infections in Hematopoietic Cell Transplant RecipientsSection P. Infections and Cancer97. Risk Factors and Infectious Agents in Children With Cancer: Fever and Granulocytopenia98. Clinical Syndromes of Infection in Children With CancerSection Q. Infections Associated With Hospitalization and Medical Devices99. Healthcare-Associated Infections100. Clinical Syndromes of Device-Associated InfectionsSection R. Infections in Patients With Deficient Defenses101. Evaluation of the Child With Suspected Immunodeficiency102. Infectious Complications of Antibody Deficiency103. Infectious Complications of Complement Deficiency and Diseases of Its Dysregulation104. Infectious Complications of Dysfunction or Deficiency of Polymorphonuclear and Mononuclear Phagocytes105. Infectious Complications of Cell-Mediated Immunity Other Than AIDS: Primary Immunodeficiencies106. Infectious Complications in Special Hosts107. Infections Related to Biologic Response Modifying Drug Therapy108. Infectious Complications of Corticosteroid TherapySection S. Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome109. Epidemiology and Prevention of HIV Infection in Infants, Children, and Adolescents110. Immunopathogenesis of HIV-1 Infection111. Diagnosis and Clinical Manifestations of HIV Infection112. Infectious Complications of HIV Infection113. Management of HIV InfectionPART III: Etiologic Agents of Infectious DiseasesSection A. Bacteria114. Classification of BacteriaGram-Positive Cocci115. Staphylococcus aureus116. Coagulase-Negative Staphylococci and Micrococcaceae117. Classification of Streptococci118. Streptococcus pyogenes (Group A Streptococcus)119. Streptococcus agalactiae (Group B Streptococcus)120. Enterococcus Species121. Viridans Streptococci, Abiotrophia and Granulicatella Species, and Streptococcus bovis Group122. Groups C and G Streptococci123. Streptococcus pneumoniae124. Other Gram-Positive, Catalase-Negative Cocci: Leuconostoc and Pediococcus Species and Other GeneraGram-Negative Cocci125. Neisseria meningitidis126. Neisseria gonorrhoeae127. Other Neisseria SpeciesGram-Positive Bacilli128. Arcanobacterium haemolyticum129. Bacillus Species (Including Anthrax)130. Corynebacterium diphtheriae131. Other Corynebacteria132. Listeria monocytogenes133. Other Gram-Positive Bacilli134. Mycobacterium tuberculosis135. Mycobacterium Nontuberculosis Species136. Nocardia SpeciesEnterobacteriaceae: Gram-Negative Bacilli137. Escherichia coli138. Klebsiella and Raoultella Species139. Klebsiella granulomatis: Granuloma Inguinale (Donovanosis)140. Enterobacter, Cronobacter, and Pantoea Species141. Citrobacter Species142. Less Commonly Encountered Enterobacterales143. Plesiomonas shigelloides144. Proteus, Providencia, and Morganella Species145. Serratia Species146. Salmonella Species147. Shigella Species148. Yersinia SpeciesNonenterobacteriaceae: Gram-Negative Bacilli149. Acinetobacter Species150. Aeromonas Species151. Less Commonly Encountered Nonenteric Gram-Negative Bacilli152. Eikenella, Pasteurella, and Chromobacterium Species153. Moraxella Species154. Pseudomonas Species and Related Organisms155. Pseudomonas aeruginosa156. Burkholderia cepacia Complex and Other Burkholderia Species157. Stenotrophomonas maltophilia158. Vibrio cholerae (Cholera)159. Other Vibrio SpeciesGram-Negative Coccobacilli160. Bartonella Species (Cat-Scratch Disease)161. Brucella Species (Brucellosis)162. Bordetella pertussis (Pertussis) and Other Bordetella Species163. Campylobacter jejuni and Campylobacter coli164. Other Campylobacter Species165. Capnocytophaga Species166. Chlamydophila (Chlamydia) pneumoniae167. Chlamydia trachomatis168. Chlamydia (Chlamydophila) psittaci (Psittacosis)169. Coxiella burnetii (Q Fever)170. Family Anaplasmataceae (Anaplasmosis, Ehrlichiosis, Neorickettsiosis, and Neoehrlichiosis)171. Francisella tularensis (Tularemia)172. Haemophilus influenzae173. Other Haemophilus Species and Aggregatibacter Species174. Helicobacter pylori175. Other Gastric and Enterohepatic Helicobacter Species176. Kingella Species177. Legionella Species178. Rickettsia rickettsii (Rocky Mountain Spotted Fever)179. Other Rickettsia Species180. Streptobacillus moniliformis (Rat-Bite Fever)181. Other Gram-Negative CoccobacilliTreponemataceae (Spiral Organisms)182. Treponema pallidum (Syphilis)183. Other Treponema Species184. Leptospira Species (Leptospirosis)185. Borrelia burgdorferi (Lyme Disease)186. Other Borrelia Species and Spirillum minusAnaerobic Bacteria187. Anaerobic Bacteria: Clinical Concepts and the Microbiome in Health and Disease188. Clostridium tetani (Tetanus)189. Clostridium botulinum (Botulism)190. Clostridioides difficile191. Other Clostridium Species192. Bacteroides and Prevotella Species and Other Anaerobic Gram-Negative Bacilli193. Fusobacterium Species194. Anaerobic Cocci195. Anaerobic Gram-Positive Nonsporulating Bacilli (Including Actinomycosis)Mycoplasma196. Mycoplasma pneumoniae197. Other Mycoplasma Species198. Ureaplasma urealyticumDiseases of Possible Infectious or Unknown Etiology199. Kawasaki Disease200. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)Section B. Viruses201. Classification of Human VirusesDNA Viruses: Poxviridae202. PoxviridaeDNA Viruses: Herpesviridae203. Introduction to Herpesviridae204. Herpes Simplex Virus205. Varicella-Zoster Virus206. Cytomegalovirus207. Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum)208. Epstein-Barr Virus (Mononucleosis and Lymphoproliferative Disorders)209. Human Herpesvirus 8 (Kaposi Sarcoma-Associated Herpesvirus)DNA Viruses: Adenoviridae210. AdenovirusesDNA Viruses: Papovaviridae211. Human Papillomavirus212. BK, JC, and Other Human PolyomavirusesDNA Viruses: Hepadnaviridae213. Hepatitis B and Hepatitis D VirusesDNA Viruses: Parvoviridae214. Human Parvoviruses (Parvovirus B19 and Bocavirus)RNA Viruses: Reoviridae215. Coltivirus (Colorado Tick Fever)216. RotavirusesRNA Viruses: Togaviridae, Flaviviridae, and Bunyaviridae217. Togaviridae: Alphaviruses218. Flaviviruses219. Bunyaviruses220. Hepatitis C Virus221. Rubella VirusRNA Viruses: Coronaviridae222. Human CoronavirusesRNA Viruses: Paramyxoviridae223. Parainfluenza Viruses224. Mumps Virus225. Respiratory Syncytial Virus226. Human Metapneumovirus227. Rubeola Virus: Measles and Subacute Sclerosing PanencephalitisRNA Viruses: Rhabdoviridae228. Rabies VirusRNA Viruses: Orthomyxoviridae229. Influenza VirusesRNA Viruses: Arenaviridae and Filoviridae230. Filoviruses and ArenavirusesRNA Viruses: Retroviridae231. Introduction to Retroviridae232. Human T-Cell Lymphotropic Viruses233. Human Immunodeficiency VirusRNA Viruses: Picornaviridae234. Introduction to Picornaviridae235. Polioviruses236. Enteroviruses and Parechoviruses237. Hepatitis A Virus238. RhinovirusesRNA Viruses: Caliciviridae239. Caliciviruses240. Astroviruses241. Hepatitis E VirusSection C. Fungi242. Classification of Fungi243. Candida Species244. Aspergillus Species245. Agents of Hyalohyphomycosis and Phaeohyphomycosis246. Agents of Mucormycosis247. Malassezia Species248. Sporothrix schenckii Complex (Sporotrichosis)249. Cryptococcus Species250. Histoplasma capsulatum (Histoplasmosis)251. Pneumocystis jirovecii252. Blastomyces Species (Blastomycosis)253. Coccidioides immitis and Coccidioides posadasii (Coccidioidomycosis)254. Superficial Fungal Infections255. Agents of Eumycotic Mycetoma: Pseudallescheria boydii and Scedosporium apiospermumSection D. Human Parasites and Vectors256. Classification of Parasites257. Ectoparasites (Lice and Scabies)Protozoa258. Babesia Species (Babesiosis)259. Balantioides coli (Formerly Balantidium coli)260. Blastocystis Species261. Cryptosporidium Species262. Endolimax nana263. Entamoeba histolytica (Amebiasis)264. Other Entamoeba, Amebae, and Intestinal Flagellates265. Giardia intestinalis (Giardiasis)266. Cystoisospora (Isospora) and Cyclospora Species267. Leishmania Species (Leishmaniasis)268. Microsporidia269. Naegleria fowleri270. Acanthamoeba Species271. Plasmodium Species (Malaria)272. Sarcocystis Species273. Toxoplasma gondii (Toxoplasmosis)274. Trichomonas vaginalis275. Trypanosoma Species (Trypanosomiasis)Nematodes276. Intestinal Nematodes277. Tissue Nematodes278. Blood and Tissue Nematodes: Filarial WormsCestodes279. Diphyllobothriidae, Dipylidium and Hymenolepis Species280. Taenia solium, Taenia asiatica, and Taenia saginata: Taeniasis and Cysticercosis281. Echinococcus Species: Agents of Echinococcosis282. Taenia (Multiceps) multiceps and Taenia serialis: CoenurosisTrematodes283. Intestinal Trematodes284. Clonorchis, Opisthorchis, Fasciola, and Paragonimus Species285. Blood Trematodes: SchistosomiasisPART IV: Laboratory Diagnosis and Therapy for Infectious DiseasesSection A. The Clinician and the Laboratory286. Laboratory Diagnosis of Infection Due to Bacteria, Fungi, Parasites, and Rickettsiae287. Laboratory Diagnosis of Infection Due to Viruses, Chlamydia, and Mycoplasma288. Use of Common Clinical Laboratory Tests to Assess Infectious and Inflammatory DiseasesSection B. Anti-Infective Therapy289. Principles of Anti-Infective Therapy290. Mechanisms and Detection of Antimicrobial Resistance291. Pharmacokinetic and Pharmacodynamic Basis of Optimal Antimicrobial Therapy292. Antibacterial Agents293. Antifungal Agents294. Topical Antimicrobial Agents295. Antiviral Agents296. Antiparasitic Agents