In this issue of MRI Clinics, guest editors Drs. Dheeraj Gandhi and Graeme F. Woodworth bring their considerable expertise to the topic of MR-Guided Focused Ultrasound. Top experts in the field cover a broad range of topics on the use of magnetic resonance-guided focused ultrasound (MRgFUS) for brain tumors, breast tumors, musculoskeletal applications, movement disorders, prostate conditions, and neurodegenerative disorders.