In this issue of Clinics in Liver Disease, guest editors Drs. Ronald J. Sokol and Sarah Taylor bring their considerable expertise to the topic of Advances in Pediatric Hepatology, An Issue of Clinics in Liver Disease. Top experts discuss recent advances in the understanding of disease mechanisms as well as new approaches to diagnosis and treatment across etiologies of pediatric liver disease. This issue incorporates new literature that provides critical updates to the basic understanding of pediatric chronic liver disease with input from national and international experts.