Peter J. H. Scott is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School. Dr. Scott edited Linker Strategies in Solid-phase Organic Synthesis (also from Wiley) and is the series editor for the Wiley Series on Solid Phase Organic Syntheses. Brian G. Hockley is Radiopharmaceutical Quality Manager at the University of Michigan Medical School, where he works with Michael Kilbourn on radiopharmaceutical research and development. Mr. Hockley has co-authored several articles and a chapter in Linker Strategies in Solid-phase Organic Synthesis (also from Wiley).

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• Contributors ixForeword xviiPreface xixAbbreviations xxiPart I Fluorine-18 Labeled Radiopharmaceuticals 11. Synthesis of [18F]-Fluorodeoxyglucose ([18F]FDG) 3Michelle L. Richards and Peter J. H. Scott2. Synthesis of Sodium [18F]Fluoride (Na[18F]F) 15Brian G. Hockley and Peter J. H. Scott3. Radiosynthesis of 3_-Deoxy-3_-[18F]Fluorothymidine ([18F]FLT) 21Hartmuth C. Kolb, Henry C. Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh B. Gangadharmath, Vani P. Mocharla, Peter J. H. Scott, and Joseph C. Walsh4. Synthesis of [18F]Fluoroazomycin Arabinoside ([18F]FAZA) 31Brian G. Hockley and Peter J. H. Scott5. Synthesis of [18F]Fluoromisonidazole (1-(2-Hydroxy-3-[18F]Fluoropropyl)-2-Nitroimidazole, [18F]FMISO) 41Patrick J. Riss, Valentina Ferrari, Robert Bielik, Roberto Canales-Candela, Rob Smith, and Franklin I. Aigbirhio6. Synthesis of [18F]FPPRGD2 51Shuanglong Liu, Frederick T. Chin, Zhen Cheng, and Xiaoyuan Chen7. Synthesis of [18F]Fluorocholine ([18F]FCH) 61David Kryza8. Clinical Manufacturing of [18F]-16-α-Fluoroestradiol ([18F]FES) 69Piyush Kumar and John R. Mercer9. Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate ([18F]SFB) 81Xia Shao10. Synthesis of 4-(2_-Methoxyphenyl)-1-[2_-(N-2__Pyridinyl)-p-[18F]Fluorobenzamido]Ethylpiperazine [18F]MPPF 87Marion Alvarez and Didier Le Bars11. Synthesis of [18F]-Fallypride 95Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio12. Synthesis of [18F]Fluoroethyltyrosine (18F-FET) 103Yi Zhao, Amar Alfteimi, and Maaz Zuhayra13. Synthesis of [18F]Flumazenil ([18F]FZ) 111Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, Carmen Wängler, and Alexander Thiel14. Synthesis of 6-[18F]Fluorodopamine (6-[18F]FDA) 125Michael A. Channing, John L. Musachio, and Jozef J. Kusmierz15. Synthesis of 2-([18F]Fluoro)-3-[(2S)-2-Azetidinylmethoxy]Pyridine ([18F]2FA) 139Hayden T. Ravert, Daniel P. Holt, and Robert F. Dannals16. Synthesis of [18F]-Substance-P Antagonist-Receptor Quantifier ([18F]SPA-RQ) 155Sofie Celen, Kim Serdons, Tjibbe de Groot, Terence G. Hamill, and Guy BormansPart II Carbon-11 Labeled Radiopharmaceuticals 16717. Synthesis of [11C]Choline Chloride ([11C]CHL) 169Brian G. Hockley, Bradford Henderson, and Xia Shao18. Synthesis of 2-(4-N-[11C]Methylaminophenyl)-6-Hydroxybenzothiazole ([11C]6-OH-BTA-1; [11C]PIB) 177Cécile Philippe, Markus Mitterhauser, and Wolfgang Wadsak19. Synthesis of [11C]-meta-Hydroxyephedrine ([11C]MHED) 191Filippo Lodi, Assunta Carpinelli, Claudio Malizia, and Stefano Boschi20. Synthesis of l-[methyl-11C]Methionine ([11C]MET) 199Amy L. Vāvere and Scott E. Snyder21. Synthesis of (+)-α-[11C]Dihydrotetrabenazine ([11C]DTBZ) 213Michael R. Kilbourn22. Synthesis of [11C]Flumazenil([11C]FMZ) 221Roberto Canales-Candela, Patrick J. Riss, and Franklin I. Aigbirhio23. Synthesis of [11C]Hexadecanoic Acid ([11C]Palmitic Acid) 233Adam C. Runkle, Xia Shao, and Peter J. H. Scott24. Synthesis of O-methyl-11C]Metomidate ([11C]-MTO) 245István Boros and Franklin I. Aigbirhio25. Synthesis of [11C]Carfentanil ([11C]CFN) 257Louis Tluczek and Xia Shao26. Synthesis of [carbonyl-11C]Way-100635 265Jan D. Andersson, Sangram Nag, Raisa N. Krasikova, Victor W. Pike, and Christer Halldin27. Synthesis of [11C]Raclopride 275Xia Shao28. Synthesis of 3-Amino-4-[2-(N-Methyl-N-[11C]Methyl-Amino-Methyl)Phenylsulfanyl]-Benzonitrile ([11C]Dasb) 285Daniela Haeusler, Markus Mitterhauser, and Wolfgang Wadsak29. Synthesis of [11C] Acetate 297Filippo Lodi, Claudio Malizia, and Stefano Boschi30. Synthesis of N-(2-[11C]Methoxybenzyl)-N-(4-Phenoxypyridin-3-yl)Acetamide ([11C]PBR28) 305Qi-Huang Zheng, Min Wang, and Bruce H. MockPart III Other Radiopharmaceuticals 31331. Synthesis of [13N]Ammonia ([13N]NH3) 315Peter J. H. Scott32. Synthesis of [68GA]Gallium Dota-(TYR3)-Octreotide Acetate ([68GA]-Dotatoc) 321Harald Eidherr, Friedrich Girschele, Markus Mitterhauser, and Wolfgang WadsakAppendix 1 Supplier Information 335Index 339

Peter J. H. Scott is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School. Dr. Scott edited Linker Strategies in Solid-phase Organic Synthesis (also from Wiley) and is the series editor for the Wiley Series on Solid Phase Organic Syntheses. Brian G. Hockley is Radiopharmaceutical Quality Manager at the University of Michigan Medical School, where he works with Michael Kilbourn on radiopharmaceutical research and development. Mr. Hockley has co-authored several articles and a chapter in Linker Strategies in Solid-phase Organic Synthesis (also from Wiley).

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• Contributors ixForeword xviiPreface xixAbbreviations xxiPart I Fluorine-18 Labeled Radiopharmaceuticals 11. Synthesis of [18F]-Fluorodeoxyglucose ([18F]FDG) 3Michelle L. Richards and Peter J. H. Scott2. Synthesis of Sodium [18F]Fluoride (Na[18F]F) 15Brian G. Hockley and Peter J. H. Scott3. Radiosynthesis of 3_-Deoxy-3_-[18F]Fluorothymidine ([18F]FLT) 21Hartmuth C. Kolb, Henry C. Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh B. Gangadharmath, Vani P. Mocharla, Peter J. H. Scott, and Joseph C. Walsh4. Synthesis of [18F]Fluoroazomycin Arabinoside ([18F]FAZA) 31Brian G. Hockley and Peter J. H. Scott5. Synthesis of [18F]Fluoromisonidazole (1-(2-Hydroxy-3-[18F]Fluoropropyl)-2-Nitroimidazole, [18F]FMISO) 41Patrick J. Riss, Valentina Ferrari, Robert Bielik, Roberto Canales-Candela, Rob Smith, and Franklin I. Aigbirhio6. Synthesis of [18F]FPPRGD2 51Shuanglong Liu, Frederick T. Chin, Zhen Cheng, and Xiaoyuan Chen7. Synthesis of [18F]Fluorocholine ([18F]FCH) 61David Kryza8. Clinical Manufacturing of [18F]-16-α-Fluoroestradiol ([18F]FES) 69Piyush Kumar and John R. Mercer9. Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate ([18F]SFB) 81Xia Shao10. Synthesis of 4-(2_-Methoxyphenyl)-1-[2_-(N-2__Pyridinyl)-p-[18F]Fluorobenzamido]Ethylpiperazine [18F]MPPF 87Marion Alvarez and Didier Le Bars11. Synthesis of [18F]-Fallypride 95Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio12. Synthesis of [18F]Fluoroethyltyrosine (18F-FET) 103Yi Zhao, Amar Alfteimi, and Maaz Zuhayra13. Synthesis of [18F]Flumazenil ([18F]FZ) 111Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, Carmen Wängler, and Alexander Thiel14. Synthesis of 6-[18F]Fluorodopamine (6-[18F]FDA) 125Michael A. Channing, John L. Musachio, and Jozef J. Kusmierz15. Synthesis of 2-([18F]Fluoro)-3-[(2S)-2-Azetidinylmethoxy]Pyridine ([18F]2FA) 139Hayden T. Ravert, Daniel P. Holt, and Robert F. Dannals16. Synthesis of [18F]-Substance-P Antagonist-Receptor Quantifier ([18F]SPA-RQ) 155Sofie Celen, Kim Serdons, Tjibbe de Groot, Terence G. Hamill, and Guy BormansPart II Carbon-11 Labeled Radiopharmaceuticals 16717. Synthesis of [11C]Choline Chloride ([11C]CHL) 169Brian G. Hockley, Bradford Henderson, and Xia Shao18. Synthesis of 2-(4-N-[11C]Methylaminophenyl)-6-Hydroxybenzothiazole ([11C]6-OH-BTA-1; [11C]PIB) 177Cécile Philippe, Markus Mitterhauser, and Wolfgang Wadsak19. Synthesis of [11C]-meta-Hydroxyephedrine ([11C]MHED) 191Filippo Lodi, Assunta Carpinelli, Claudio Malizia, and Stefano Boschi20. Synthesis of l-[methyl-11C]Methionine ([11C]MET) 199Amy L. Vāvere and Scott E. Snyder21. Synthesis of (+)-α-[11C]Dihydrotetrabenazine ([11C]DTBZ) 213Michael R. Kilbourn22. Synthesis of [11C]Flumazenil([11C]FMZ) 221Roberto Canales-Candela, Patrick J. Riss, and Franklin I. Aigbirhio23. Synthesis of [11C]Hexadecanoic Acid ([11C]Palmitic Acid) 233Adam C. Runkle, Xia Shao, and Peter J. H. Scott24. Synthesis of O-methyl-11C]Metomidate ([11C]-MTO) 245István Boros and Franklin I. Aigbirhio25. Synthesis of [11C]Carfentanil ([11C]CFN) 257Louis Tluczek and Xia Shao26. Synthesis of [carbonyl-11C]Way-100635 265Jan D. Andersson, Sangram Nag, Raisa N. Krasikova, Victor W. Pike, and Christer Halldin27. Synthesis of [11C]Raclopride 275Xia Shao28. Synthesis of 3-Amino-4-[2-(N-Methyl-N-[11C]Methyl-Amino-Methyl)Phenylsulfanyl]-Benzonitrile ([11C]Dasb) 285Daniela Haeusler, Markus Mitterhauser, and Wolfgang Wadsak29. Synthesis of [11C] Acetate 297Filippo Lodi, Claudio Malizia, and Stefano Boschi30. Synthesis of N-(2-[11C]Methoxybenzyl)-N-(4-Phenoxypyridin-3-yl)Acetamide ([11C]PBR28) 305Qi-Huang Zheng, Min Wang, and Bruce H. MockPart III Other Radiopharmaceuticals 31331. Synthesis of [13N]Ammonia ([13N]NH3) 315Peter J. H. Scott32. Synthesis of [68GA]Gallium Dota-(TYR3)-Octreotide Acetate ([68GA]-Dotatoc) 321Harald Eidherr, Friedrich Girschele, Markus Mitterhauser, and Wolfgang WadsakAppendix 1 Supplier Information 335Index 339

Peter J. H. Scott is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School. Dr. Scott edited Linker Strategies in Solid-phase Organic Synthesis (also from Wiley) and is the series editor for the Wiley Series on Solid Phase Organic Syntheses. Brian G. Hockley is Radiopharmaceutical Quality Manager at the University of Michigan Medical School, where he works with Michael Kilbourn on radiopharmaceutical research and development. Mr. Hockley has co-authored several articles and a chapter in Linker Strategies in Solid-phase Organic Synthesis (also from Wiley).

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• Contributors ixForeword xviiPreface xixAbbreviations xxiPart I Fluorine-18 Labeled Radiopharmaceuticals 11. Synthesis of [18F]-Fluorodeoxyglucose ([18F]FDG) 3Michelle L. Richards and Peter J. H. Scott2. Synthesis of Sodium [18F]Fluoride (Na[18F]F) 15Brian G. Hockley and Peter J. H. Scott3. Radiosynthesis of 3_-Deoxy-3_-[18F]Fluorothymidine ([18F]FLT) 21Hartmuth C. Kolb, Henry C. Padgett, Steve Zigler, Jim Patanella, Fanrong Mu, Umesh B. Gangadharmath, Vani P. Mocharla, Peter J. H. Scott, and Joseph C. Walsh4. Synthesis of [18F]Fluoroazomycin Arabinoside ([18F]FAZA) 31Brian G. Hockley and Peter J. H. Scott5. Synthesis of [18F]Fluoromisonidazole (1-(2-Hydroxy-3-[18F]Fluoropropyl)-2-Nitroimidazole, [18F]FMISO) 41Patrick J. Riss, Valentina Ferrari, Robert Bielik, Roberto Canales-Candela, Rob Smith, and Franklin I. Aigbirhio6. Synthesis of [18F]FPPRGD2 51Shuanglong Liu, Frederick T. Chin, Zhen Cheng, and Xiaoyuan Chen7. Synthesis of [18F]Fluorocholine ([18F]FCH) 61David Kryza8. Clinical Manufacturing of [18F]-16-α-Fluoroestradiol ([18F]FES) 69Piyush Kumar and John R. Mercer9. Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate ([18F]SFB) 81Xia Shao10. Synthesis of 4-(2_-Methoxyphenyl)-1-[2_-(N-2__Pyridinyl)-p-[18F]Fluorobenzamido]Ethylpiperazine [18F]MPPF 87Marion Alvarez and Didier Le Bars11. Synthesis of [18F]-Fallypride 95Laurent Brichard, Valentina Ferrari, Rob Smith, and Franklin I. Aigbirhio12. Synthesis of [18F]Fluoroethyltyrosine (18F-FET) 103Yi Zhao, Amar Alfteimi, and Maaz Zuhayra13. Synthesis of [18F]Flumazenil ([18F]FZ) 111Ralf Schirrmacher, Alexey Kostikov, Gassan Massaweh, Miriam Kovacevic, Carmen Wängler, and Alexander Thiel14. Synthesis of 6-[18F]Fluorodopamine (6-[18F]FDA) 125Michael A. Channing, John L. Musachio, and Jozef J. Kusmierz15. Synthesis of 2-([18F]Fluoro)-3-[(2S)-2-Azetidinylmethoxy]Pyridine ([18F]2FA) 139Hayden T. Ravert, Daniel P. Holt, and Robert F. Dannals16. Synthesis of [18F]-Substance-P Antagonist-Receptor Quantifier ([18F]SPA-RQ) 155Sofie Celen, Kim Serdons, Tjibbe de Groot, Terence G. Hamill, and Guy BormansPart II Carbon-11 Labeled Radiopharmaceuticals 16717. Synthesis of [11C]Choline Chloride ([11C]CHL) 169Brian G. Hockley, Bradford Henderson, and Xia Shao18. Synthesis of 2-(4-N-[11C]Methylaminophenyl)-6-Hydroxybenzothiazole ([11C]6-OH-BTA-1; [11C]PIB) 177Cécile Philippe, Markus Mitterhauser, and Wolfgang Wadsak19. Synthesis of [11C]-meta-Hydroxyephedrine ([11C]MHED) 191Filippo Lodi, Assunta Carpinelli, Claudio Malizia, and Stefano Boschi20. Synthesis of l-[methyl-11C]Methionine ([11C]MET) 199Amy L. Vāvere and Scott E. Snyder21. Synthesis of (+)-α-[11C]Dihydrotetrabenazine ([11C]DTBZ) 213Michael R. Kilbourn22. Synthesis of [11C]Flumazenil([11C]FMZ) 221Roberto Canales-Candela, Patrick J. Riss, and Franklin I. Aigbirhio23. Synthesis of [11C]Hexadecanoic Acid ([11C]Palmitic Acid) 233Adam C. Runkle, Xia Shao, and Peter J. H. Scott24. Synthesis of O-methyl-11C]Metomidate ([11C]-MTO) 245István Boros and Franklin I. Aigbirhio25. Synthesis of [11C]Carfentanil ([11C]CFN) 257Louis Tluczek and Xia Shao26. Synthesis of [carbonyl-11C]Way-100635 265Jan D. Andersson, Sangram Nag, Raisa N. Krasikova, Victor W. Pike, and Christer Halldin27. Synthesis of [11C]Raclopride 275Xia Shao28. Synthesis of 3-Amino-4-[2-(N-Methyl-N-[11C]Methyl-Amino-Methyl)Phenylsulfanyl]-Benzonitrile ([11C]Dasb) 285Daniela Haeusler, Markus Mitterhauser, and Wolfgang Wadsak29. Synthesis of [11C] Acetate 297Filippo Lodi, Claudio Malizia, and Stefano Boschi30. Synthesis of N-(2-[11C]Methoxybenzyl)-N-(4-Phenoxypyridin-3-yl)Acetamide ([11C]PBR28) 305Qi-Huang Zheng, Min Wang, and Bruce H. MockPart III Other Radiopharmaceuticals 31331. Synthesis of [13N]Ammonia ([13N]NH3) 315Peter J. H. Scott32. Synthesis of [68GA]Gallium Dota-(TYR3)-Octreotide Acetate ([68GA]-Dotatoc) 321Harald Eidherr, Friedrich Girschele, Markus Mitterhauser, and Wolfgang WadsakAppendix 1 Supplier Information 335Index 339