Drug Therapy for Infectious Diseases of the Dog and Cat

Valerie J. Wiebe, Pharm. D, FSVHP, Dip. ICVP, is the Director of Pharmacy at the University of California, Davis Veterinary Medical Teaching Hospital, where she has an appointment as Adjunct Associate Professor in the Department of Internal Medicine, in Davis, California, USA.  She also maintains an adjunct Clinical Professorship at the University of San Francisco, Department of Pharmacy, in San Francisco, California, USA.

“Overall, I found this book to be a useful clinical handbook well worth the price. It is recommended as a practical clinical reference for small animal practitioners with limited experience in the area of infectious disease or veterinary students interested in learning clinical information necessary to effectively treat dogs and cats with common infectious diseases.”  (Journal of the American Veterinary Medical Association, 15 December 2015)“A very useful tool to enrich whatever formulary may be lying in the consulting room.”  (Vet Nurses Today, 1 October 2015)"This book is quite unique in its systematic and logic structure and is a welcome addendum to current literature in this topic." (EJCAP 2016)"From diagnosis and dosages to risk factors and resources for further reading in professional veterinary publications, all the guidelines and details are written with clinical settings in mind, making this a top office pick." (Midwest Book Review 2016)

• Preface ixAcknowledgments xSection A: Pharmacology Guidelines1 Understanding Minimum Inhibitory Concentrations (MICs) 12 Static versus Cidal Antibiotics 13 In Vitro versus In Vivo Efficacy 24 Approaching Infectious Disease Cases 25 Why Antibiotics Fail 46 Adjusting Doses in Renal Failure 57 Pregnancy Risk Categories 68 Lactation Guidelines: Penetration of Drugs into Milk 79 Safe Writing Skills 710 Basic Math Skills 8Section B: Empiric Therapy Pending Diagnostic Results11 Arthritis, Osteomyelitis 912 Bacteremia and Sepsis 1013 Central Nervous System Infections (Meningitis) 1114 Endocarditis (Bacterial) 1215 Intra‐Abdominal Infections 1316 Neonatal Infections 1417 Infections Associated with Neutropenia 1518 Otitis Externa and Otitis Media 1519 Pancreatitis 1620 Peritonitis and Abscesses 1721 Pneumonia/Bronchitis 1822 Prostatitis 1923 Pyothorax Infections 2024 Sinus Infections 2025 Skin and Soft Tissue Infections 2126 Urinary Tract Infections 22Section C: Therapy of Established Infections27 Acanthamoeba 2528 Acinetobacter 2629 Actinomyces 2730 Adenovirus (Infectious Canine Hepatitis) 2831 Aelurostrongylus Abstrusus (Feline Lungworm) 2932 Anaerobic Species (Bacteroides and Provotella) 3033 Anaplasma Species 3034 Ancylostoma Species (Hookworms) 3135 Ascaris Species (Roundworms) 3236 Aspergillus Species 3337 Babesia Species 3538 Bartonella Species (Cat Scratch Disease) 3639 Blastomycosis 3740 Bordetella Bronchiseptica (Kennel Cough) 3841 Borrelia Burgdorferi (Lyme Disease) 3942 Brucella (Canine Brucellosis) 4043 Calicivirus 4244 Campylobacter Species 4345 Candida Species 4346 Canine Influenza Virus (CIV) 4447 Capillaria Aerophila (Lungworm) 4548 Cestode Species (Tapeworms) 4649 Cheyletiella Species (Walking Dandruff) 4750 Chlamydia Species 4851 Citrobacter Species 4952 Clostridium Difficile 5053 Clostridium Tetani/Botulinum 5154 Coccidiomycosis 5255 Corynebacterium Species 5356 Coxiellosis Species (Q Fever) 5457 Cryptococcus Species 5558 Cryptosporidium Species 5659 Ctenocephalides Species (Fleas) 5660 Cuterebra Species (Botfly Larvae) 5761 Cytauxzoon Felis 5962 Dematiaceous Fungi (Phaeohypomycosis, Chromoblastomycosis) 5963 Demodex Canis/Felis (Red Mange) 6064 Dermatophytosis 6165 Dipylidium Caninum (Flea Tapeworm) 6266 Dirofilaria Immitis (Heartworm) 6367 Distemper (Canine) 6468 Ehrlichia Species 6569 Entamoeba Histolytica 6670 Enterobacter Species 6771 Enterococcus 6872 Erysipelothrix Species 6973 Escherichia Coli (Enterotoxigenic/ Enterohemorrhagic) 7074 Eschericha Coli (Nonenterohemorrhagic) 7175 Feline Coronovirus (Feline Infectious Peritonitis: FIP) 7276 Feline Immunodeficiency Virus (FIV) 7377 Feline Leukemia Virus (FeLV) 7478 Feline Panleukopenia Virus 7579 Francisella Tularensis (Tularemia) 7580 Fusarium Species 7681 Giardia Species 7782 Helicobacter Species 7883 Hepatozoon Americanum/Canis (Hepatozoonosis) 7984 Herpes Virus (Canine) 8085 Histoplasma Capsulatum 8086 Hyalohyphomycosis (Paecilomyces/Scedosporium) 8187 Isospora Species 8288 Klebsiella Species 8389 Leishmaniosis 8490 Leptospira Species 8591 Lice 8692 Malassezia 8793 Microsporidia 8894 Mucor Species 8995 Mycobacterium Species 9096 Mycoplasma Species 9197 Myiasis (Maggots) 9298 Neospora Caninum 9299 Neorickettsia Helminthoeca 93100 Nocardia Species 94101 Otodectes Cynotis (Otodectic Mange) 95102 Papilloma Virus 96103 Paragonimus Species (Liver Flukes) 97104 Parvovirus 97105 Pasteurella Species 98106 Poxvirus 99107 Proteus Species 100108 Prototheca Species 101109 Pseudomonas Aeruginosa 102110 Pseudorabies (Aujeszky’s Disease) 103111 Rabies Virus 104112 Rhodococcus Equi 104113 Rickettsia Rickettsii (Rocky Mountain Spotted Fever) 105114 Salmonella Species 106115 Sarcoptes Scabiei (Sarcoptic Mange) 107116 Serratia Species 108117 Shigella Species 109118 Sporothrix Species 110119 Staphylococcus Species 111120 Streptococcus Species 112121 Strongyloides Species (Threadworms) 113122 Toxocara Canis/Cati 114123 Toxoplasma Gondii (Toxoplasmosis) 115124 Trichomonas Species 115125 Yersinia Pestis (Plaque) 116Section D: Antibiotics126 Amikacin 118127 Amoxicillin 120128 Ampicillin 122129 Azithromycin 124130 Cefadroxil 126131 Cefazolin 128132 Cefdinir 130133 Cefepime 132134 Cefotaxime 134135 Cefovecin 136136 Cefoxitin 138137 Cefpodoxime 140138 Ceftazidime 142139 Ceftiofur 143140 Cefuroxime 145141 Cephalexin 147142 Chloramphenicol 149143 Ciprofloxacin 151144 Clarithromycin 153145 Clavamox 155146 Clindamycin 157147 Dicloxacillin 159148 Doxycycline 161149 Enrofloxacin 163150 Erythromycin 166151 Florfenicol 168152 Gentamicin 170153 Imipenem and Cilastatin 172154 Linezolid 174155 Marbofloxacin 176156 Meropenem 178157 Metronidazole 180158 Minocycline 182159 Nitrofurantoin 185160 Orbifloxacin 187161 Oxytetracycline 189162 Penicillin 191163 Pradofloxacin 193164 Rifampin 195165 Potentiated Sulfas 197166 Timentin 200167 Tobramycin 202168 Tylosin 204169 Unasyn 206170 Vancomycin 208171 Zosyn 211Section E: Antifungal Agents172 Amphotericin B 221173 Caspofungin 224174 Clotrimazole 226175 Enilconazole 228176 Fluconazole 230177 Flucytosine 232178 Itraconazole 234179 Ketoconazole 237180 Posaconazole 239181 Terbinafine 241182 Voriconazole 243Section F: Antiparasitic Agents183 Albendazole 247184 Atovaquone 249185 Fenbendazole 251186 Fipronil 253187 Imidacloprid 255188 Imidocarb Dipropionate 257189 Ivermectin 259190 Lufenuron 262191 Meglumine Antimoniate 263192 Melarsomine 265193 Miltefosine 268194 Milbemycin Oxime 269195 Moxidectin 272196 Nitazoxanide 274197 Nitenpyram 276198 Ponazuril (Toltrazuril Sulfone) 278199 Praziquantel 280200 Primaquine Phosphate 282201 Pyrantel Pamoate 283202 Ronidazole 285203 Selamectin 287204 Spinosid 289205 Sulfadimethoxine 291206 Tinidazole 294Section G: Antiviral Agents207 Acyclovir 297208 Famciclovir 299209 Cidofovir 301210 Idoxuridine 302211 Oseltamivir 304212 Vidarabine 306213 Zidovudine 307Index 310