Karol A. Mathews, DVM, DVSc, DACVECC, is Professor Emerita, Emergency and Critical Care Medicine at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Melissa Sinclair, DVM, DVSc, DACVAA, is Associate Professor in Anesthesiology at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Andrea M. Steele, MSc, RVT (VTS ECC), is an ICU Technician at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Tamara Grubb, DVM, PhD, DACVAA, is Associate Clinical Professor of Anesthesia and Analgesia at Washington State University's College of Veterinary Medicine in Pullman, Washington, USA.

"[This book] is designed to be a desktop manual and is written in a manner that provides readers quick and easy access to detailed information on the topics discussed.  The book is written by highly respected experts in the field, and the content flows smoothly through their different areas of knowledge and experience…. It is a valuable addition to our clinic’s reference library, and I will be suggesting it as a reference to students who rotate through our emergency service." JAVMA, MAR 15, 2019, VOL 254, NO. 6

• List of Contributors viiiPreface ix Acknowledgements x1 General Considerations for Pain Management upon Initial Presentation and during Hospital Stay Karol Mathews2 Physiology and Pathophysiology of Pain 8Tamara Grubb3 Physiologic and Pharmacologic Applications to Manage Neuropathic Pain 17Karol Mathews4 Physiology and Pharmacology: Clinical Application to Abdominal and Pelvic Visceral Pain 51Karol Mathews5 Physiology and Management of Cancer Pain 64Karol Mathews and Michelle Oblak6 Movement‐Evoked and Breakthrough Pain 68Karol Mathews7 Pain: Understanding It 70Karol Mathews8 Recognition, Assessment and Treatment of Pain in Dogs and Cat 81Karol Mathews9 Pharmacologic and Clinical Application of Sedatives 112Melissa Sinclair10 Pharmacologic and Clinical Application of Opioid Analgesics 119Melissa Sinclair11 Pharmacologic and Clinical Application of Non‐Steroidal Anti‐Inflammatory Analgesics 134Karol Mathews12 Pharmacologic and Clinical Principles of Adjunct Analgesia 144Karol Mathews and Tamara Grubb13 Pharmacologic and Clinical Application of General Anesthetics 165Melissa Sinclair14 Local Anesthetic Techniques  171Alexander Valverde15 Integrative Techniques for Pain Management 204Cornelia Mosley and Shauna Cantwell16 The Veterinary Technician/Nurse’s Role in Pain Management   217Andrea Steele17 Optimal Nursing Care for the Management of Pain 219Andrea Steele18 Preparation and Delivery of Analgesics 230Andrea Steele19 Cardiovascular Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 244Tamara Grubb20 Kidney Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 255Melissa Sinclair21 Liver Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 263Melissa Sinclair22 Managing the Aggressive Patient  270Andrea Steele and Tamara Grubb23 Analgesia and Anesthesia for Pregnant Cats and Dogs 279Karol Mathews and Melissa Sinclair24 Analgesia and Anesthesia for Nursing Cats and Dogs 294Karol Mathews, Tamara Grubb, Melissa Sinclair and Andrea Steele25 Physiologic and Pharmacologic Application of Analgesia and Anesthesia for the Pediatric Patient  308Karol Mathews, Tamara Grubb and Andrea Steele26 Analgesia and Anesthesia for the Geriatric Patient 328Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb27 Analgesia and Anesthesia for Head and Neck Injuries or Illness 336Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb28 Torso, Thorax and Thoracic Cavity: Illness and Injury  356Karol Mathews, Tamara Grubb and Andrea Steele29 Torso and Abdomen: Illness and Injuries 375Karol Mathews, Tamara Grubb and Andrea Steele30 Pelvic Cavity/Abdomen, Perineum and Torso: Illness and Injuries Urogenital System and Perineum 391Karol Mathews, Tamara Grubb and Andrea Steele31 Musculoskeletal Injuries and Illness 409Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb32 Vertebral Column (Vertebrae and Spinal Cord)  423Karol Mathews, Tamara Grubb and Andrea Steele33 Integument Injuries and Illness 439Karol Mathews, Tamara Grubb and Andrea Steele34 Environmental Injuries 454Karol Mathews, Tamara Grubb and Andrea SteeleIndex 465

Karol A. Mathews, DVM, DVSc, DACVECC, is Professor Emerita, Emergency and Critical Care Medicine at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Melissa Sinclair, DVM, DVSc, DACVAA, is Associate Professor in Anesthesiology at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Andrea M. Steele, MSc, RVT (VTS ECC), is an ICU Technician at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Tamara Grubb, DVM, PhD, DACVAA, is Associate Clinical Professor of Anesthesia and Analgesia at Washington State University's College of Veterinary Medicine in Pullman, Washington, USA.

"[This book] is designed to be a desktop manual and is written in a manner that provides readers quick and easy access to detailed information on the topics discussed.  The book is written by highly respected experts in the field, and the content flows smoothly through their different areas of knowledge and experience…. It is a valuable addition to our clinic’s reference library, and I will be suggesting it as a reference to students who rotate through our emergency service." JAVMA, MAR 15, 2019, VOL 254, NO. 6

• List of Contributors viiiPreface ix Acknowledgements x1 General Considerations for Pain Management upon Initial Presentation and during Hospital Stay Karol Mathews2 Physiology and Pathophysiology of Pain 8Tamara Grubb3 Physiologic and Pharmacologic Applications to Manage Neuropathic Pain 17Karol Mathews4 Physiology and Pharmacology: Clinical Application to Abdominal and Pelvic Visceral Pain 51Karol Mathews5 Physiology and Management of Cancer Pain 64Karol Mathews and Michelle Oblak6 Movement‐Evoked and Breakthrough Pain 68Karol Mathews7 Pain: Understanding It 70Karol Mathews8 Recognition, Assessment and Treatment of Pain in Dogs and Cat 81Karol Mathews9 Pharmacologic and Clinical Application of Sedatives 112Melissa Sinclair10 Pharmacologic and Clinical Application of Opioid Analgesics 119Melissa Sinclair11 Pharmacologic and Clinical Application of Non‐Steroidal Anti‐Inflammatory Analgesics 134Karol Mathews12 Pharmacologic and Clinical Principles of Adjunct Analgesia 144Karol Mathews and Tamara Grubb13 Pharmacologic and Clinical Application of General Anesthetics 165Melissa Sinclair14 Local Anesthetic Techniques  171Alexander Valverde15 Integrative Techniques for Pain Management 204Cornelia Mosley and Shauna Cantwell16 The Veterinary Technician/Nurse’s Role in Pain Management   217Andrea Steele17 Optimal Nursing Care for the Management of Pain 219Andrea Steele18 Preparation and Delivery of Analgesics 230Andrea Steele19 Cardiovascular Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 244Tamara Grubb20 Kidney Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 255Melissa Sinclair21 Liver Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 263Melissa Sinclair22 Managing the Aggressive Patient  270Andrea Steele and Tamara Grubb23 Analgesia and Anesthesia for Pregnant Cats and Dogs 279Karol Mathews and Melissa Sinclair24 Analgesia and Anesthesia for Nursing Cats and Dogs 294Karol Mathews, Tamara Grubb, Melissa Sinclair and Andrea Steele25 Physiologic and Pharmacologic Application of Analgesia and Anesthesia for the Pediatric Patient  308Karol Mathews, Tamara Grubb and Andrea Steele26 Analgesia and Anesthesia for the Geriatric Patient 328Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb27 Analgesia and Anesthesia for Head and Neck Injuries or Illness 336Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb28 Torso, Thorax and Thoracic Cavity: Illness and Injury  356Karol Mathews, Tamara Grubb and Andrea Steele29 Torso and Abdomen: Illness and Injuries 375Karol Mathews, Tamara Grubb and Andrea Steele30 Pelvic Cavity/Abdomen, Perineum and Torso: Illness and Injuries Urogenital System and Perineum 391Karol Mathews, Tamara Grubb and Andrea Steele31 Musculoskeletal Injuries and Illness 409Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb32 Vertebral Column (Vertebrae and Spinal Cord)  423Karol Mathews, Tamara Grubb and Andrea Steele33 Integument Injuries and Illness 439Karol Mathews, Tamara Grubb and Andrea Steele34 Environmental Injuries 454Karol Mathews, Tamara Grubb and Andrea SteeleIndex 465

Karol A. Mathews, DVM, DVSc, DACVECC, is Professor Emerita, Emergency and Critical Care Medicine at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Melissa Sinclair, DVM, DVSc, DACVAA, is Associate Professor in Anesthesiology at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Andrea M. Steele, MSc, RVT (VTS ECC), is an ICU Technician at the Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada. Tamara Grubb, DVM, PhD, DACVAA, is Associate Clinical Professor of Anesthesia and Analgesia at Washington State University's College of Veterinary Medicine in Pullman, Washington, USA.

"[This book] is designed to be a desktop manual and is written in a manner that provides readers quick and easy access to detailed information on the topics discussed.  The book is written by highly respected experts in the field, and the content flows smoothly through their different areas of knowledge and experience…. It is a valuable addition to our clinic’s reference library, and I will be suggesting it as a reference to students who rotate through our emergency service." JAVMA, MAR 15, 2019, VOL 254, NO. 6

• List of Contributors viiiPreface ix Acknowledgements x1 General Considerations for Pain Management upon Initial Presentation and during Hospital Stay Karol Mathews2 Physiology and Pathophysiology of Pain 8Tamara Grubb3 Physiologic and Pharmacologic Applications to Manage Neuropathic Pain 17Karol Mathews4 Physiology and Pharmacology: Clinical Application to Abdominal and Pelvic Visceral Pain 51Karol Mathews5 Physiology and Management of Cancer Pain 64Karol Mathews and Michelle Oblak6 Movement‐Evoked and Breakthrough Pain 68Karol Mathews7 Pain: Understanding It 70Karol Mathews8 Recognition, Assessment and Treatment of Pain in Dogs and Cat 81Karol Mathews9 Pharmacologic and Clinical Application of Sedatives 112Melissa Sinclair10 Pharmacologic and Clinical Application of Opioid Analgesics 119Melissa Sinclair11 Pharmacologic and Clinical Application of Non‐Steroidal Anti‐Inflammatory Analgesics 134Karol Mathews12 Pharmacologic and Clinical Principles of Adjunct Analgesia 144Karol Mathews and Tamara Grubb13 Pharmacologic and Clinical Application of General Anesthetics 165Melissa Sinclair14 Local Anesthetic Techniques  171Alexander Valverde15 Integrative Techniques for Pain Management 204Cornelia Mosley and Shauna Cantwell16 The Veterinary Technician/Nurse’s Role in Pain Management   217Andrea Steele17 Optimal Nursing Care for the Management of Pain 219Andrea Steele18 Preparation and Delivery of Analgesics 230Andrea Steele19 Cardiovascular Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 244Tamara Grubb20 Kidney Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 255Melissa Sinclair21 Liver Disease as a Co‐Morbidity for Anesthesia and Analgesia of Non‐Related Emergencies 263Melissa Sinclair22 Managing the Aggressive Patient  270Andrea Steele and Tamara Grubb23 Analgesia and Anesthesia for Pregnant Cats and Dogs 279Karol Mathews and Melissa Sinclair24 Analgesia and Anesthesia for Nursing Cats and Dogs 294Karol Mathews, Tamara Grubb, Melissa Sinclair and Andrea Steele25 Physiologic and Pharmacologic Application of Analgesia and Anesthesia for the Pediatric Patient  308Karol Mathews, Tamara Grubb and Andrea Steele26 Analgesia and Anesthesia for the Geriatric Patient 328Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb27 Analgesia and Anesthesia for Head and Neck Injuries or Illness 336Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb28 Torso, Thorax and Thoracic Cavity: Illness and Injury  356Karol Mathews, Tamara Grubb and Andrea Steele29 Torso and Abdomen: Illness and Injuries 375Karol Mathews, Tamara Grubb and Andrea Steele30 Pelvic Cavity/Abdomen, Perineum and Torso: Illness and Injuries Urogenital System and Perineum 391Karol Mathews, Tamara Grubb and Andrea Steele31 Musculoskeletal Injuries and Illness 409Karol Mathews, Melissa Sinclair, Andrea Steele and Tamara Grubb32 Vertebral Column (Vertebrae and Spinal Cord)  423Karol Mathews, Tamara Grubb and Andrea Steele33 Integument Injuries and Illness 439Karol Mathews, Tamara Grubb and Andrea Steele34 Environmental Injuries 454Karol Mathews, Tamara Grubb and Andrea SteeleIndex 465