Edited byAdrian Vella MD is the Earl and Annette R. McDonough Professor of Medicine, and the Research Chair of the Division of Diabetes, Endocrinology & Metabolism in the Department of Medicine, Mayo Clinic College of Medicine, US

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• List of Contributors, viiPreface, xPart I Prediabetes and the Diagnosis of Diabetes1 “Is Prediabetes a Risk Factor or Is It a Disease?” 3Jacob Kohlenberg and Adrian Vella2 Early Diagnosis of Type 1 Diabetes – Useful or a Pyrrhic Victory? 17Paolo Pozzilli and Silvia Pieralice3 Reclassifying or Declassifying Diabetes? Can Clinical Characteristics Guide Classification andTreatment? 37Adrian Vella4 How Should Secondary Causes of Diabetes Be Excluded? 45Tomás P. Griffin, Aonghus O’Loughlin, and Sean F. Dinneen5 How to Screen Appropriately for Monogenic Diabetes 68Adrian VellaPart II Initial Evaluation and Management of Diabetes6 Managing Gestational Diabetes During and After Pregnancy 75Aoife M. Egan and Fidelma P. Dunne7 What Is the Role of Self‐Monitoring in Diabetes? Is There a Role for Postprandial Glucose Monitoring? How Does Continuous Glucose Monitoring Integrate into Clinical Practice? 87Rami Almokayyad and Robert Cuddihy8 Does HbA1c Remain the Most Important Therapeutic Target in Outpatient Management of Diabetes? 101Kristen Gonzales and Steve A. Smith9 Technology Issues: Continuous Glucose Monitoring, Insulin Pumps, and Closed Loop Control for Patients with Diabetes 115Ravinder Jeet Kaur, Shafaq R. Rizvi and Yogish C. Kudva10 Optimizing Diet in Patients with Diabetes 124Meera Shah11 Are Insulin Sensitizers Useful Additions to Insulin Therapy? 133John W. Richard, III and Philip Raskin12 Incretin‐Based Therapy for the Management of Type 2 Diabetes 146Kristin Gonzales and Adrian VellaPart III Diagnosis and Management of Cardiovascular Risk Factors and Cardiovascular Disease13 Screening Patients with Prediabetes and Diabetes for Cardiovascular Disease 163Sabreen Ahmed, Saritha Tirumalasetty and Vivian Fonseca14 Choosing Medications for Type 2 Diabetes – What Weighting Should Be Given to Cardiovascular Risk Reduction? 174Adrian Vella15 Choosing Medications for Weight Loss in Type 2 Diabetes Mellitus 187Shubhada Jagasia, Chase Dean Hendrickson and Alexander J. Williams16 Are Statins the Optimal Therapy for Cardiovascular Risk in Patients with Diabetes? What Newer Agents Are There for the Treatment for Dyslipidemia in Diabetes? Are Triglycerides an Important Risk Factor for Diabetes? 198Recie Davern and Timothy O’Brien17 New Agents for Treatment of Dyslipidemia 211Vinaya Simha18 The Role of Bariatric Surgery in Obese Patients with Diabetes: Primary or Rescue Therapy? 220Praveena Gandikota and Blandine Laferrère19 Treatment Strategies in Patients with Diabetes Mellitus and Ischemic Heart Disease 228Madeline K. Mahowald, Chiam Leker Locker, Mandeep Singh and Robert L. FryePart IV Management of Disease Complications20 Diabetes Management in Patients with Critical and Non-Critical Illness 241Kalpana Muthusamy, Kristin Grdinovac and John M. Miles21 Diagnosis and Management of Ophthalmic Complications of Diabetes 252Andrew J. Barkmeier and Konstantin Astafurov22 Upper Gastrointestinal Manifestations of Diabetes 269Michael CamilleriIndex 280

Edited byAdrian Vella MD is the Earl and Annette R. McDonough Professor of Medicine, and the Research Chair of the Division of Diabetes, Endocrinology & Metabolism in the Department of Medicine, Mayo Clinic College of Medicine, US

Select Guide Rating

• List of Contributors, viiPreface, xPart I Prediabetes and the Diagnosis of Diabetes1 “Is Prediabetes a Risk Factor or Is It a Disease?” 3Jacob Kohlenberg and Adrian Vella2 Early Diagnosis of Type 1 Diabetes – Useful or a Pyrrhic Victory? 17Paolo Pozzilli and Silvia Pieralice3 Reclassifying or Declassifying Diabetes? Can Clinical Characteristics Guide Classification andTreatment? 37Adrian Vella4 How Should Secondary Causes of Diabetes Be Excluded? 45Tomás P. Griffin, Aonghus O’Loughlin, and Sean F. Dinneen5 How to Screen Appropriately for Monogenic Diabetes 68Adrian VellaPart II Initial Evaluation and Management of Diabetes6 Managing Gestational Diabetes During and After Pregnancy 75Aoife M. Egan and Fidelma P. Dunne7 What Is the Role of Self‐Monitoring in Diabetes? Is There a Role for Postprandial Glucose Monitoring? How Does Continuous Glucose Monitoring Integrate into Clinical Practice? 87Rami Almokayyad and Robert Cuddihy8 Does HbA1c Remain the Most Important Therapeutic Target in Outpatient Management of Diabetes? 101Kristen Gonzales and Steve A. Smith9 Technology Issues: Continuous Glucose Monitoring, Insulin Pumps, and Closed Loop Control for Patients with Diabetes 115Ravinder Jeet Kaur, Shafaq R. Rizvi and Yogish C. Kudva10 Optimizing Diet in Patients with Diabetes 124Meera Shah11 Are Insulin Sensitizers Useful Additions to Insulin Therapy? 133John W. Richard, III and Philip Raskin12 Incretin‐Based Therapy for the Management of Type 2 Diabetes 146Kristin Gonzales and Adrian VellaPart III Diagnosis and Management of Cardiovascular Risk Factors and Cardiovascular Disease13 Screening Patients with Prediabetes and Diabetes for Cardiovascular Disease 163Sabreen Ahmed, Saritha Tirumalasetty and Vivian Fonseca14 Choosing Medications for Type 2 Diabetes – What Weighting Should Be Given to Cardiovascular Risk Reduction? 174Adrian Vella15 Choosing Medications for Weight Loss in Type 2 Diabetes Mellitus 187Shubhada Jagasia, Chase Dean Hendrickson and Alexander J. Williams16 Are Statins the Optimal Therapy for Cardiovascular Risk in Patients with Diabetes? What Newer Agents Are There for the Treatment for Dyslipidemia in Diabetes? Are Triglycerides an Important Risk Factor for Diabetes? 198Recie Davern and Timothy O’Brien17 New Agents for Treatment of Dyslipidemia 211Vinaya Simha18 The Role of Bariatric Surgery in Obese Patients with Diabetes: Primary or Rescue Therapy? 220Praveena Gandikota and Blandine Laferrère19 Treatment Strategies in Patients with Diabetes Mellitus and Ischemic Heart Disease 228Madeline K. Mahowald, Chiam Leker Locker, Mandeep Singh and Robert L. FryePart IV Management of Disease Complications20 Diabetes Management in Patients with Critical and Non-Critical Illness 241Kalpana Muthusamy, Kristin Grdinovac and John M. Miles21 Diagnosis and Management of Ophthalmic Complications of Diabetes 252Andrew J. Barkmeier and Konstantin Astafurov22 Upper Gastrointestinal Manifestations of Diabetes 269Michael CamilleriIndex 280

Edited byAdrian Vella MD is the Earl and Annette R. McDonough Professor of Medicine, and the Research Chair of the Division of Diabetes, Endocrinology & Metabolism in the Department of Medicine, Mayo Clinic College of Medicine, US

Select Guide Rating

• List of Contributors, viiPreface, xPart I Prediabetes and the Diagnosis of Diabetes1 “Is Prediabetes a Risk Factor or Is It a Disease?” 3Jacob Kohlenberg and Adrian Vella2 Early Diagnosis of Type 1 Diabetes – Useful or a Pyrrhic Victory? 17Paolo Pozzilli and Silvia Pieralice3 Reclassifying or Declassifying Diabetes? Can Clinical Characteristics Guide Classification andTreatment? 37Adrian Vella4 How Should Secondary Causes of Diabetes Be Excluded? 45Tomás P. Griffin, Aonghus O’Loughlin, and Sean F. Dinneen5 How to Screen Appropriately for Monogenic Diabetes 68Adrian VellaPart II Initial Evaluation and Management of Diabetes6 Managing Gestational Diabetes During and After Pregnancy 75Aoife M. Egan and Fidelma P. Dunne7 What Is the Role of Self‐Monitoring in Diabetes? Is There a Role for Postprandial Glucose Monitoring? How Does Continuous Glucose Monitoring Integrate into Clinical Practice? 87Rami Almokayyad and Robert Cuddihy8 Does HbA1c Remain the Most Important Therapeutic Target in Outpatient Management of Diabetes? 101Kristen Gonzales and Steve A. Smith9 Technology Issues: Continuous Glucose Monitoring, Insulin Pumps, and Closed Loop Control for Patients with Diabetes 115Ravinder Jeet Kaur, Shafaq R. Rizvi and Yogish C. Kudva10 Optimizing Diet in Patients with Diabetes 124Meera Shah11 Are Insulin Sensitizers Useful Additions to Insulin Therapy? 133John W. Richard, III and Philip Raskin12 Incretin‐Based Therapy for the Management of Type 2 Diabetes 146Kristin Gonzales and Adrian VellaPart III Diagnosis and Management of Cardiovascular Risk Factors and Cardiovascular Disease13 Screening Patients with Prediabetes and Diabetes for Cardiovascular Disease 163Sabreen Ahmed, Saritha Tirumalasetty and Vivian Fonseca14 Choosing Medications for Type 2 Diabetes – What Weighting Should Be Given to Cardiovascular Risk Reduction? 174Adrian Vella15 Choosing Medications for Weight Loss in Type 2 Diabetes Mellitus 187Shubhada Jagasia, Chase Dean Hendrickson and Alexander J. Williams16 Are Statins the Optimal Therapy for Cardiovascular Risk in Patients with Diabetes? What Newer Agents Are There for the Treatment for Dyslipidemia in Diabetes? Are Triglycerides an Important Risk Factor for Diabetes? 198Recie Davern and Timothy O’Brien17 New Agents for Treatment of Dyslipidemia 211Vinaya Simha18 The Role of Bariatric Surgery in Obese Patients with Diabetes: Primary or Rescue Therapy? 220Praveena Gandikota and Blandine Laferrère19 Treatment Strategies in Patients with Diabetes Mellitus and Ischemic Heart Disease 228Madeline K. Mahowald, Chiam Leker Locker, Mandeep Singh and Robert L. FryePart IV Management of Disease Complications20 Diabetes Management in Patients with Critical and Non-Critical Illness 241Kalpana Muthusamy, Kristin Grdinovac and John M. Miles21 Diagnosis and Management of Ophthalmic Complications of Diabetes 252Andrew J. Barkmeier and Konstantin Astafurov22 Upper Gastrointestinal Manifestations of Diabetes 269Michael CamilleriIndex 280