Donald G. Barceloux, MD, Author: Dr. Barceloux is a Medical Toxicologist in the Department of Emergency Medicine at Pomona Valley Community Hospital. For over 20 years, he served as a Clinical Professor of Medicine at the Olive View/University of California, Los Angeles School of Medicine Department of Emergency Medicine. He received his A.B. in Biology, B.S. in General Engineering, and M.S. in Engineering Science from Stanford University, and his medical training at the University of California, Los Angeles. He is a Consultant in Medical Toxicology including the diagnosis and treatment of poisoning, health surveillance, biological monitoring, interpretation of risk assessment and toxicological data, and determination of the medical effects of exposures to chemicals and drugs. He co-authored the First Edition of Medical Toxicology: Diagnosis and Treatment of Human Poisoning as well as various other toxicology related publications on metals, solvents, alcohols, natural substances, drugs of abuse, and the treatment of poisonings. This volume is the third book in his Medical Toxicology series, which provides concise, detailed coverage on the medical toxicology of metals, radiation, and chemical carcinogens. The first two volumes were Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants, and Venomous Animals and Medical Toxicology of Drug Abuse: Synthetic Chemicals and Psychoactive Plants. His work in Medical Toxicology and Emergency Medicine has been recognized by fellowship in the American Academy of Clinical Toxicology, the American College of Medical Toxicology, and the American College of Emergency Medicine.Robert B. Palmer, PhD, Editor: Dr. Palmer is a board-certified clinical toxicologist in private practice with Toxicology Associates, PLLC and is an attending toxicologist at the Rocky Mountain Poison and Drug Service in Denver, CO. He holds academic appointments at the University of Colorado and University of Wyoming. Dr. Palmer previously served on the Board of Directors of the American Board of Applied Toxicology (ABAT) and the Board of Trustees of the Academy of Clinical Toxicology (AACT) including serving as AACT president. He is a frequent author and speaker on many aspects of clinical and forensic toxicology.

• Foreword xxiPreface xxiiiAcknowledgments xxvReview Panel xxviVolume 3 Carcinogens: Risk Factors, Pathophysiology, Susceptibility, and Clinical Abnormalities 1A Carcinogenesis 347 Carcinogenesis 5B Chemical Carcinogenicity 5748 General Principles 5949 Evaluating Carcinogenicity 7550 Carcinogen Classifications 15151 Risk Assessment 16952 Cancer Surveillance 203C Tumor Sites 21753 Respiratory Tract 21954 Gastrointestinal Tract 27355 Urinary Tract 33756 Male Reproductive Tract 36557 Female Reproductive Tract 39158 Central Nervous System 44159 Leukemia 48360 Lymphomas 53961 Skin 62962 Soft Tissue and Bone Sarcomas 66763 Thyroid 691Index 705

Donald G. Barceloux, MD, Author: Dr. Barceloux is a Medical Toxicologist in the Department of Emergency Medicine at Pomona Valley Community Hospital. For over 20 years, he served as a Clinical Professor of Medicine at the Olive View/University of California, Los Angeles School of Medicine Department of Emergency Medicine. He received his A.B. in Biology, B.S. in General Engineering, and M.S. in Engineering Science from Stanford University, and his medical training at the University of California, Los Angeles. He is a Consultant in Medical Toxicology including the diagnosis and treatment of poisoning, health surveillance, biological monitoring, interpretation of risk assessment and toxicological data, and determination of the medical effects of exposures to chemicals and drugs. He co-authored the First Edition of Medical Toxicology: Diagnosis and Treatment of Human Poisoning as well as various other toxicology related publications on metals, solvents, alcohols, natural substances, drugs of abuse, and the treatment of poisonings. This volume is the third book in his Medical Toxicology series, which provides concise, detailed coverage on the medical toxicology of metals, radiation, and chemical carcinogens. The first two volumes were Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants, and Venomous Animals and Medical Toxicology of Drug Abuse: Synthetic Chemicals and Psychoactive Plants. His work in Medical Toxicology and Emergency Medicine has been recognized by fellowship in the American Academy of Clinical Toxicology, the American College of Medical Toxicology, and the American College of Emergency Medicine.Robert B. Palmer, PhD, Editor: Dr. Palmer is a board-certified clinical toxicologist in private practice with Toxicology Associates, PLLC and is an attending toxicologist at the Rocky Mountain Poison and Drug Service in Denver, CO. He holds academic appointments at the University of Colorado and University of Wyoming. Dr. Palmer previously served on the Board of Directors of the American Board of Applied Toxicology (ABAT) and the Board of Trustees of the Academy of Clinical Toxicology (AACT) including serving as AACT president. He is a frequent author and speaker on many aspects of clinical and forensic toxicology.

• Foreword xxiPreface xxiiiAcknowledgments xxvReview Panel xxviVolume 3 Carcinogens: Risk Factors, Pathophysiology, Susceptibility, and Clinical Abnormalities 1A Carcinogenesis 347 Carcinogenesis 5B Chemical Carcinogenicity 5748 General Principles 5949 Evaluating Carcinogenicity 7550 Carcinogen Classifications 15151 Risk Assessment 16952 Cancer Surveillance 203C Tumor Sites 21753 Respiratory Tract 21954 Gastrointestinal Tract 27355 Urinary Tract 33756 Male Reproductive Tract 36557 Female Reproductive Tract 39158 Central Nervous System 44159 Leukemia 48360 Lymphomas 53961 Skin 62962 Soft Tissue and Bone Sarcomas 66763 Thyroid 691Index 705

Donald G. Barceloux, MD, Author: Dr. Barceloux is a Medical Toxicologist in the Department of Emergency Medicine at Pomona Valley Community Hospital. For over 20 years, he served as a Clinical Professor of Medicine at the Olive View/University of California, Los Angeles School of Medicine Department of Emergency Medicine. He received his A.B. in Biology, B.S. in General Engineering, and M.S. in Engineering Science from Stanford University, and his medical training at the University of California, Los Angeles. He is a Consultant in Medical Toxicology including the diagnosis and treatment of poisoning, health surveillance, biological monitoring, interpretation of risk assessment and toxicological data, and determination of the medical effects of exposures to chemicals and drugs. He co-authored the First Edition of Medical Toxicology: Diagnosis and Treatment of Human Poisoning as well as various other toxicology related publications on metals, solvents, alcohols, natural substances, drugs of abuse, and the treatment of poisonings. This volume is the third book in his Medical Toxicology series, which provides concise, detailed coverage on the medical toxicology of metals, radiation, and chemical carcinogens. The first two volumes were Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants, and Venomous Animals and Medical Toxicology of Drug Abuse: Synthetic Chemicals and Psychoactive Plants. His work in Medical Toxicology and Emergency Medicine has been recognized by fellowship in the American Academy of Clinical Toxicology, the American College of Medical Toxicology, and the American College of Emergency Medicine.Robert B. Palmer, PhD, Editor: Dr. Palmer is a board-certified clinical toxicologist in private practice with Toxicology Associates, PLLC and is an attending toxicologist at the Rocky Mountain Poison and Drug Service in Denver, CO. He holds academic appointments at the University of Colorado and University of Wyoming. Dr. Palmer previously served on the Board of Directors of the American Board of Applied Toxicology (ABAT) and the Board of Trustees of the Academy of Clinical Toxicology (AACT) including serving as AACT president. He is a frequent author and speaker on many aspects of clinical and forensic toxicology.

• Foreword xxiPreface xxiiiAcknowledgments xxvReview Panel xxviVolume 3 Carcinogens: Risk Factors, Pathophysiology, Susceptibility, and Clinical Abnormalities 1A Carcinogenesis 347 Carcinogenesis 5B Chemical Carcinogenicity 5748 General Principles 5949 Evaluating Carcinogenicity 7550 Carcinogen Classifications 15151 Risk Assessment 16952 Cancer Surveillance 203C Tumor Sites 21753 Respiratory Tract 21954 Gastrointestinal Tract 27355 Urinary Tract 33756 Male Reproductive Tract 36557 Female Reproductive Tract 39158 Central Nervous System 44159 Leukemia 48360 Lymphomas 53961 Skin 62962 Soft Tissue and Bone Sarcomas 66763 Thyroid 691Index 705