New Angiotherapy

From the Foreword by Judah Folkman, "In this very timely and informative book, Tai Ping Fan and Elise Kohn have assembled chapters authored by many of the leading scientists in the field of angiogenesis research. The molecular underpinnings of the angiogenic process in reproduction, development, repair and in disease, are clearly developed. Broad coverage is given to preclinical and clinical applications of angiogenesis inhibitors, and the book is a valuable source of references to the many aspects of the angiogenic process...The importance of quantifying effectiveness of antiangiogenic therapy is just one of many new directions in angiogenesis research both basic and clinical, which are highlighted by the authors. Future directions are also emphasized in the chapters on gene therapy, therapeutic angiogenesis for ischemic disease of the heart and limbs, and in new thinking about preventive antiangiogenic therapy." -Judah Folkman, July 2001 "This is an excellent collection of reviews in the field of angiogenesis therapy. This is an important area because growth factors are now in the clinical trials in the cardiovascular arena in an attempt to grow new vessels for ischemic disease. At the same time, antiangiogenesis is being evaluated to prevent tumor growth and neovascularization in the diabetic retina. Each chapter is well referenced and the index is very helpful in locating specific points in the book. This is an important addition to the medical literature. "-Doody's Health Sciences Book Review Journal, 96 score, 4 stars! "Fan and Kohn have assembled a group of international experts who have written up-to-date and detailed chapters on all aspects of the processes. The term 'therapeutic angiogenesis' encompasses the use of angiogenesis stimulation to overcome certain disease states. The material is quite detailed and aimed at investigators, but the book as a whole is an excellent reference for anyone interested in the field." - Oncology

• 1 Vasculogenesis and Angiogenesis.- 2 Angiogenesis-Regulating Cytokines.- 3 The Angiopoietins.- 4 Regulation of Vascular Morphogenesis by Extracellular Matrix Proteins.- 5 Integrin Receptors and the Regulation of Angiogenesis.- 6 Vasoactive Peptides in Angiogenesis.- 7 Angiogenesis in Wound Healing and Surgery.- 8 Angiogenesis and Vascular Endothelial Growth Factor (VEGF) in Reproduction.- 9 Rheumatoid Arthritis: A Target for Anti-Angiogenic Therapy?.- 10 Diagnostic and Prognostic Significance of Tumor Angiogenesis.- 11 Hyaluronan Oligosaccharides Promote Wound Repair: Its Size-Dependent Regulation of Angiogenesis.- 12 Role of Thymic Peptides in Wound Healing.- 13 Angiogenesis and Growth Factors in Ulcer Healing.- 14 Angiogenesis in Skeletal and Cardiac Muscle: Role of Mechanical Factors.- 15 Therapeutic Angiogenesis for the Treatment of Cardiovascular Disease.- 16 Therapeutic Angiogenesis for the Heart.- 17 Contact-Guided Angiogenesis and Tissue Engineering.- 18 Inhibitors of Matrix Metalloproteinases.- 19 Control of Angiogenesis by Microbial Products.- 20 Interaction of Angiogenic Growth Factors with Endothelial Cell Heparan Sulfate Proteoglycans: Implications for the Development of Angiostatic Compounds.- 21 2-Methoxyestradiol: A Novel Endogenous Chemotherapeutic and Anti-Angiogenic Agent.- 22 Receptor Tyrosine Kinases in Angiogenesis.- 23 Targeting Gene Therapy to the Tumor Vasculature.- 24 Antibody Targeting of Tumor Vasculature.- 25 Endothelial Monocyte-Activating Polypeptide II: A Novel Injury Signal?.- 26 CD105 Antibody for Targeting of Tumor Vascular Endothelial Cells.- 27 Design of Pharmacological and Diagnostic Strategies for Angiogenesis-Dependent Diseases.- 28 Design of Clinical Trials for Anti-Angiogenics.- 29 Angiogeneis Therapies: Concepts, Clinical Trials, and Considerations for New Drug Development.- 30 Angiostatin and Endostatin: Recent Advances in Their Biology, Pharmacokinetics, and Potential Clinical Applications.