Adrenomedullin in Cardiovascular Disease

AvToshio Nishikimi

Häftad, Engelska, 2014

Del 19 i serien Basic Science for the Cardiologist

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Beskrivning

Adrenomedullin was discovered in 1993 in an extract of human pheochromocytoma while monitoring cAMP levels in rat platelets. Adrenomedullin has attracted considerable interest among cardiologists due to its impact on the cardiovascular system which includes a decrease in blood pressure in vivo; an impact on vascular smooth muscle cells; increases cAMP levels; indirectly reduces blood pressure and has role in the pathogenesis of arteriosclerosis.Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease.

Produktinformation

Utgivningsdatum:2014-12-02
Mått:155 x 235 x 13 mm
Vikt:359 g
Format:Häftad
Språk:Engelska
Serie:Basic Science for the Cardiologist
Antal sidor:219
Upplaga:2005
Förlag:Springer-Verlag New York Inc.
ISBN:9781489994295

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Hjärt- och kärlsjukdomar inom Medicin

Mer om författaren

Toshio Nishikimi, MD, PhD, is an Associate Professor in the Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.

Innehållsförteckning

Biochemistry of Adrenomedullin.- Adrenomedullin Receptor and Signal Transduction.- Adrenomedullin Gene.- Adrenomedullin Expression and Secretion.- Biological Action of Adrenomedullin.- Circulating Adrenomedullin.- Role of Adrenomedullin in Cardiovascular Diseases.- Adrenomedullin as an Adipokine.- Adrenomedullin Knockout Mouse and Transgenic Mouse.- Pleiotropic Effect of Adrenomedullin: Lessons from Pure Adrenomedullin Knockout Mouse.- Therapeutic Application of Adrenomedullin.- Therapeutic Potentials of Adrenomedullin for Heart Failure and Pulmonary Hypertension.

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