Domino Reactions

Lutz F. Tietze studied chemistry at the universities of Freiburg and Kiel, Germany and obtained his doctorate under the supervision of Prof. B. Franck in 1968 in Kiel. He then worked as a research associate with Prof. G. Büchi at MIT, Cambridge, USA, as well as with Prof. A. Battersby in Cambridge, UK. Since 1978 he has been Professor and Head of the Institute of Organic and Biomolecular Chemistry at the Georg-August-University in Göttingen. His research focuses on the development of efficient and selective synthetic methods, combinatorial chemistry, the total synthesis of natural products and the design of new selective anticancer agents. Professor Tietze has received many prizes, including the award for his book on "Reactions and Syntheses" by the Fonds der Chemischen Industrie, the Grignard-Wittig Prize of the Société Française de Chimie, the Prix Charles Mentzer of the Société de Chimie Thérapeutique France and the highly prestigious Emil Fischer Medal of the German Chemical Society. He was speaker of a Sonderforschungsbereich (Collaborative Research Centre), member of the DFG Fachkollegium and obtained several guest professorships. Moreover, he is chairman of the German Zentralverband der Chemie (Steering Committee of the German Chemical Societies), is member of a center of excellence and has been awarded in 2012 with the position of a Distinguished Research Professor. He has over 460 papers, 34 patents and four books to his name.

• PrefaceIntroduction TRANSITION METAL-CATALYZED CARBONYLATIVE DOMINO REACTIONSIntroductionTransition Metal-Catalyzed Carbonylative Domino ReactionsOutlook METATHESIS REACTIONS IN DOMINO PROCESSESDomino Processes Featuring Solely Metathesis EventsDomino Processes Featuring Metathesis and Non-Metathesis EventsConclusion and Outlook C-H ACTIVATION REACTIONS IN DOMINO PROCESSESHeck Reactions/C-H ActivationsCarbopalladations and Aminopalladations of Alkynes/C-H ActivationsPalladium-Catalyzed/Norbornene-Mediated ortho C-H ActivationsDomino Reactions Involving Heteroatom-Directed C-H ActivationsConclusions DOMINO REACTIONS INITIATED BY NUCLEOPHILIC SUBSTITUTIONDomino SN/Michael Addition and Related ReactionsDomino Reactions Initiated by Nucleophilic Ring Opening of Aziridines, Epoxides and Activated CyclopropanesDomino SN/Brook Rearrangements RADICAL REACTIONS IN DOMINO PROCESSESIntroductionRadical/Cation Domino ProcessesRadical/Anionic Domino ProcessesDomino Radical/Radical ProcessRadical/Pericyclic Domino ProcessesAsymmetric Radical Domino ProcessesConclusion and Outlook PERICYCLIC REACTIONS IN DOMINO PROCESSESIntroductionCycloadditionsSigmatropic RearrangementsElectrocyclizationsMixed TransformationsConcluding Remarks MODERN DOMINO REACTIONS CONTAINING A MICHAEL ADDITION REACTIONIntroductionFormation of Acyclic ProductsFormation of CarbocyclesFormation of O-HeterocyclesFormation of N-HeterocyclesFormation of S-HeterocyclesFormation of Heterocycles Containing Nitrogen and Oxygen ALDOL REACTIONS IN DOMINO PROCESSESIntroductionDomino Processes with the Aldol Reaction as First StepDomino Processes with the Aldol Reaction as Subsequent StepConclusion and Outlook OXIDATIONS AND REDUCTIONS IN DOMINO PROCESSESIntroductionDomino Reactions Initiated by Oxidation or Reduction ReactionDomino Reactions Having Oxidation in Middle of the SequenceDomino Reactions Terminated by Oxidation or Reduction ReactionConclusion ORGANOCATALYSIS IN DOMINO PROCESSESIntroductionOne and Two-Component Domino ReactionsMulticomponent ReactionsConclusions METAL-CATALYZED ENANTIO- AND DIASTEREOSELECTIVE C-C BOND FORMING REACTIONS IN DOMINO PROCESSESDomino Reaction Initiated by C-C Bond FormationDomino Reaction Initiated by C-H Bond FormationDomino Reaction Initiated by C-N Bond FormationDomino Reaction Initiated by C-O Bond FormationDomino Reaction Initiated by C-B and C-Si Bond FormationConclusion and Outlook DOMINO PROCESSES UNDER MICROWAVA IRRADIATION, HIGH PRESSURE, AND IN WATERIntroductionMicrowave-Assisted Domino ReactionsAqueous Domino ReactionsHigh-Pressure-Promoted Domino ReactionsConclusion and Outlook DOMINO REACTIONS IN LIBRARY SYNTHESISIntroductionDomino Reactions in Natural-Product-Inspired Compound Collection SynthesesDomino Approaches Targeting Scaffold DiversitySolid-Phase Domino Syntheses of Compound CollectionsConclusion DOMINO REACTIONS IN THE TOTAL SYNTHESIS OF NATURAL PRODUCTSCationic Domino ReactionsAnionic Domino ReactionsRadical Domino ReactionsPericyclic Domino ReactionsTransition-Metal-Catalyzed Domino ReactionsDomino Reactions Initiated by Oxidation or ReductionConlcusion MULTICOMPONENT DOMINO PROCESS: RATIONAL DESIGN AND SERENDIPITYIntroductionBasic Considerations of MCRsSubstrate-Design Approach in the Development of Novel MCRsConclusion Index