Steeve Giguere , DVM, PhD, DACVIM, is Professor of Large Animal Internal Medicine and the Marguerite Hodgson Chair in Equine Studies at the College of Veterinary Medicine, University of Georgia, in Athens, Georgia. John F. Prescott , MA, VetMB, PhD, is Professor in the Department of Pathobiology at the University of Guelph in Guelph, Ontario. Patricia M. Dowling , DVM, MS, DACVIM, DACVCP, is Professor of Veterinary Clinical Pharmacology at the University of Saskatchewan in Saskatoon, Saskatchewan.

• Contributors ix Preface xiii Important Notice xv Abbreviations xvii Section I General Principles of Antimicrobial Therapy 1 1 Antimicrobial Drug Action and Interaction: An Introduction 3 Steeve Giguere 2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 11 Joseph E. Rubin 3 Antimicrobial Resistance and its Epidemiology 21 Patrick Boerlin and David G. White 4 Principles of Antimicrobial Drug Bioavailability and Disposition 41 J. Desmond Baggot and Steeve Giguere 5 The Pharmacodynamics of Antimicrobial Agents 79 Marilyn N. Martinez, Pierre-Louis Toutain, and John Turnidge 6 Principles of Antimicrobial Drug Selection and Use 105 Steeve Giguere 7 Antimicrobial Stewardship in Animals 117 J. Scott Weese, Stephen W. Page, and John F. Prescott Section II Classes of Antimicrobial Agents 133 8 Beta-lactam Antibiotics: Penam Penicillins 135 John F. Prescott 9 Beta-lactam Antibiotics: Cephalosporins 153 John F. Prescott 10 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 175 John F. Prescott 11 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 189 Patricia M. Dowling 12 Lincosamides, Pleuromutilins, and Streptogramins 199 Steeve Giguere 13 Macrolides, Azalides, and Ketolides 211 Steeve Giguere 14 Aminoglycosides and Aminocyclitols 233 Patricia M. Dowling 15 Tetracyclines 257 Jerome R.E. del Castillo 16 Chloramphenicol, Thiamphenicol, and Florfenicol 269 Patricia M. Dowling 17 Sulfonamides, Diaminopyrimidines, and Their Combinations 279 John F. Prescott 18 Fluoroquinolones 295 Steeve Giguere and Patricia M. Dowling 19 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 315 Patricia M. Dowling 20 Antifungal Chemotherapy 333 Steeve Giguere Section III Special Considerations 357 21 Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient 359 Steeve Giguere, Anthony C.G. Abrams-Ogg, and Stephen A. Kruth 22 Performance Uses of Antimicrobial Agents and Non-antimicrobial Alternatives 379 Thomas R. Shryock and Stephen W. Page 23 Antimicrobial Therapy of Selected Organ Systems 395 Patricia M. Dowling 24 Antimicrobial Therapy of Selected Bacterial Infections 421 Steeve Giguere 25 Antimicrobial Drug Residues in Foods of Animal Origin 431 Patricia M. Dowling 26 Regulation of Antimicrobial Use in Animals 443 Karolina Torneke and Christopher Boland Section iv A ntimicrobial Drug Use in Selected Animal Species 455 27 Antimicrobial Drug Use in Horses 457 Steeve Giguere and Tiago Afonso 28 Antimicrobial Drug Use in Dogs and Cats 473 Jane E. Sykes 29 Antimicrobial Drug Use in Cattle 495 Michael D. Apley and Johann F. Coetzee 30 Antimicrobial Drug Use in Mastitis 519 Sarah Wagner and Ron Erskine 31 Antimicrobial Drug Use in Sheep and Goats 529 Chris R. Clark 32 Antimicrobial Drug Use in New World Camelids 541 Christopher K. Cebra and Margaret L. Cebra 33 Antimicrobial Drug Use in Swine 553 David G.S. Burch 34 Antimicrobial Drug Use in Poultry 569 Charles L. Hofacre, Jenny A. Fricke, and Tom Inglis 35 Antimicrobial Drug Use in Companion Birds 589 Keven Flammer 36 Antimicrobial Drug Use in Rabbits, Rodents, and Ferrets 601 Colette L. Wheler 37 Antimicrobial Drug Use in Reptiles 623 Ramiro Isaza and Elliott R. Jacobson 38 Antimicrobial Drug Use in Zoological Animals 637 Ellen Wiedner and Robert P. Hunter 39 Antimicrobial Drug Use in Aquaculture 645 Renate Reimschuessel, Ron A. Miller, and Charles M. Gieseker Index 663

Steeve Giguere , DVM, PhD, DACVIM, is Professor of Large Animal Internal Medicine and the Marguerite Hodgson Chair in Equine Studies at the College of Veterinary Medicine, University of Georgia, in Athens, Georgia. John F. Prescott , MA, VetMB, PhD, is Professor in the Department of Pathobiology at the University of Guelph in Guelph, Ontario. Patricia M. Dowling , DVM, MS, DACVIM, DACVCP, is Professor of Veterinary Clinical Pharmacology at the University of Saskatchewan in Saskatoon, Saskatchewan.

• Contributors ix Preface xiii Important Notice xv Abbreviations xvii Section I General Principles of Antimicrobial Therapy 1 1 Antimicrobial Drug Action and Interaction: An Introduction 3 Steeve Giguere 2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 11 Joseph E. Rubin 3 Antimicrobial Resistance and its Epidemiology 21 Patrick Boerlin and David G. White 4 Principles of Antimicrobial Drug Bioavailability and Disposition 41 J. Desmond Baggot and Steeve Giguere 5 The Pharmacodynamics of Antimicrobial Agents 79 Marilyn N. Martinez, Pierre-Louis Toutain, and John Turnidge 6 Principles of Antimicrobial Drug Selection and Use 105 Steeve Giguere 7 Antimicrobial Stewardship in Animals 117 J. Scott Weese, Stephen W. Page, and John F. Prescott Section II Classes of Antimicrobial Agents 133 8 Beta-lactam Antibiotics: Penam Penicillins 135 John F. Prescott 9 Beta-lactam Antibiotics: Cephalosporins 153 John F. Prescott 10 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 175 John F. Prescott 11 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 189 Patricia M. Dowling 12 Lincosamides, Pleuromutilins, and Streptogramins 199 Steeve Giguere 13 Macrolides, Azalides, and Ketolides 211 Steeve Giguere 14 Aminoglycosides and Aminocyclitols 233 Patricia M. Dowling 15 Tetracyclines 257 Jerome R.E. del Castillo 16 Chloramphenicol, Thiamphenicol, and Florfenicol 269 Patricia M. Dowling 17 Sulfonamides, Diaminopyrimidines, and Their Combinations 279 John F. Prescott 18 Fluoroquinolones 295 Steeve Giguere and Patricia M. Dowling 19 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 315 Patricia M. Dowling 20 Antifungal Chemotherapy 333 Steeve Giguere Section III Special Considerations 357 21 Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient 359 Steeve Giguere, Anthony C.G. Abrams-Ogg, and Stephen A. Kruth 22 Performance Uses of Antimicrobial Agents and Non-antimicrobial Alternatives 379 Thomas R. Shryock and Stephen W. Page 23 Antimicrobial Therapy of Selected Organ Systems 395 Patricia M. Dowling 24 Antimicrobial Therapy of Selected Bacterial Infections 421 Steeve Giguere 25 Antimicrobial Drug Residues in Foods of Animal Origin 431 Patricia M. Dowling 26 Regulation of Antimicrobial Use in Animals 443 Karolina Torneke and Christopher Boland Section iv A ntimicrobial Drug Use in Selected Animal Species 455 27 Antimicrobial Drug Use in Horses 457 Steeve Giguere and Tiago Afonso 28 Antimicrobial Drug Use in Dogs and Cats 473 Jane E. Sykes 29 Antimicrobial Drug Use in Cattle 495 Michael D. Apley and Johann F. Coetzee 30 Antimicrobial Drug Use in Mastitis 519 Sarah Wagner and Ron Erskine 31 Antimicrobial Drug Use in Sheep and Goats 529 Chris R. Clark 32 Antimicrobial Drug Use in New World Camelids 541 Christopher K. Cebra and Margaret L. Cebra 33 Antimicrobial Drug Use in Swine 553 David G.S. Burch 34 Antimicrobial Drug Use in Poultry 569 Charles L. Hofacre, Jenny A. Fricke, and Tom Inglis 35 Antimicrobial Drug Use in Companion Birds 589 Keven Flammer 36 Antimicrobial Drug Use in Rabbits, Rodents, and Ferrets 601 Colette L. Wheler 37 Antimicrobial Drug Use in Reptiles 623 Ramiro Isaza and Elliott R. Jacobson 38 Antimicrobial Drug Use in Zoological Animals 637 Ellen Wiedner and Robert P. Hunter 39 Antimicrobial Drug Use in Aquaculture 645 Renate Reimschuessel, Ron A. Miller, and Charles M. Gieseker Index 663

Steeve Giguere , DVM, PhD, DACVIM, is Professor of Large Animal Internal Medicine and the Marguerite Hodgson Chair in Equine Studies at the College of Veterinary Medicine, University of Georgia, in Athens, Georgia. John F. Prescott , MA, VetMB, PhD, is Professor in the Department of Pathobiology at the University of Guelph in Guelph, Ontario. Patricia M. Dowling , DVM, MS, DACVIM, DACVCP, is Professor of Veterinary Clinical Pharmacology at the University of Saskatchewan in Saskatoon, Saskatchewan.

• Contributors ix Preface xiii Important Notice xv Abbreviations xvii Section I General Principles of Antimicrobial Therapy 1 1 Antimicrobial Drug Action and Interaction: An Introduction 3 Steeve Giguere 2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 11 Joseph E. Rubin 3 Antimicrobial Resistance and its Epidemiology 21 Patrick Boerlin and David G. White 4 Principles of Antimicrobial Drug Bioavailability and Disposition 41 J. Desmond Baggot and Steeve Giguere 5 The Pharmacodynamics of Antimicrobial Agents 79 Marilyn N. Martinez, Pierre-Louis Toutain, and John Turnidge 6 Principles of Antimicrobial Drug Selection and Use 105 Steeve Giguere 7 Antimicrobial Stewardship in Animals 117 J. Scott Weese, Stephen W. Page, and John F. Prescott Section II Classes of Antimicrobial Agents 133 8 Beta-lactam Antibiotics: Penam Penicillins 135 John F. Prescott 9 Beta-lactam Antibiotics: Cephalosporins 153 John F. Prescott 10 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 175 John F. Prescott 11 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 189 Patricia M. Dowling 12 Lincosamides, Pleuromutilins, and Streptogramins 199 Steeve Giguere 13 Macrolides, Azalides, and Ketolides 211 Steeve Giguere 14 Aminoglycosides and Aminocyclitols 233 Patricia M. Dowling 15 Tetracyclines 257 Jerome R.E. del Castillo 16 Chloramphenicol, Thiamphenicol, and Florfenicol 269 Patricia M. Dowling 17 Sulfonamides, Diaminopyrimidines, and Their Combinations 279 John F. Prescott 18 Fluoroquinolones 295 Steeve Giguere and Patricia M. Dowling 19 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 315 Patricia M. Dowling 20 Antifungal Chemotherapy 333 Steeve Giguere Section III Special Considerations 357 21 Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient 359 Steeve Giguere, Anthony C.G. Abrams-Ogg, and Stephen A. Kruth 22 Performance Uses of Antimicrobial Agents and Non-antimicrobial Alternatives 379 Thomas R. Shryock and Stephen W. Page 23 Antimicrobial Therapy of Selected Organ Systems 395 Patricia M. Dowling 24 Antimicrobial Therapy of Selected Bacterial Infections 421 Steeve Giguere 25 Antimicrobial Drug Residues in Foods of Animal Origin 431 Patricia M. Dowling 26 Regulation of Antimicrobial Use in Animals 443 Karolina Torneke and Christopher Boland Section iv A ntimicrobial Drug Use in Selected Animal Species 455 27 Antimicrobial Drug Use in Horses 457 Steeve Giguere and Tiago Afonso 28 Antimicrobial Drug Use in Dogs and Cats 473 Jane E. Sykes 29 Antimicrobial Drug Use in Cattle 495 Michael D. Apley and Johann F. Coetzee 30 Antimicrobial Drug Use in Mastitis 519 Sarah Wagner and Ron Erskine 31 Antimicrobial Drug Use in Sheep and Goats 529 Chris R. Clark 32 Antimicrobial Drug Use in New World Camelids 541 Christopher K. Cebra and Margaret L. Cebra 33 Antimicrobial Drug Use in Swine 553 David G.S. Burch 34 Antimicrobial Drug Use in Poultry 569 Charles L. Hofacre, Jenny A. Fricke, and Tom Inglis 35 Antimicrobial Drug Use in Companion Birds 589 Keven Flammer 36 Antimicrobial Drug Use in Rabbits, Rodents, and Ferrets 601 Colette L. Wheler 37 Antimicrobial Drug Use in Reptiles 623 Ramiro Isaza and Elliott R. Jacobson 38 Antimicrobial Drug Use in Zoological Animals 637 Ellen Wiedner and Robert P. Hunter 39 Antimicrobial Drug Use in Aquaculture 645 Renate Reimschuessel, Ron A. Miller, and Charles M. Gieseker Index 663