Encyclopedia of Mass Spectrometry, Ten-Volume Set – serie

The focus of Volume 2 of the Encyclopedia of Mass Spectrometry is on peptides and proteins, separation techniques, preparation protocols, and the fundamental characteristics as ionic gas phase species that lie within the breadth of the field of mass spectrometry. This volume is divided into four sections; experimental approaches and protocols, sequence analysis, other structural analyses, and targeted applications. Frontier Research on biological, biochemical, and biomedical applications of MS Focus on Peptides and Proteins Suitable for new graduate students entering the field

Volume 6: Ionization Methods captures the story of molecular ionization and its phenomenal evolution that makes mass spectrometry the powerful method it is today. Chapters 1 and 2 cover fundamentals and various issues that are common to all ionization (e.g., accurate mass, isotope clusters, and derivatization).

Chapters 3-9 acknowledge that some ionization methods are appropriate for gas-phase molecules and others for molecules that are in the solid or liquid states. Chapters 3-6 cover gas-phase molecules, dividing the subject into: (1) ionization of gas-phase molecules by particles (e.g., EI), (2) ionization by photons, (3) ionization by ion-molecule and molecule-molecule reactions (e.g., APCI and DART), and ionization in Strong electric fields (i.e., Electrohydrodynamic and Field Ionization/Desorption).

"Ionization in a Strong Electric Field" illustrates the transition to ionization of molecules in the solid or liquid states, covered in Chapters 7-9: (1) spray methods for ionization (e.g., electrospray), (2) desorption ionization by particle bombardment (e.g., FAB), and (3) desorption by photons (e.g., MALDI). Electrospray and MALDI also lead to applications in biophysical chemistry, the theme of Chapter 10.

Chapter 11 reconsiders ionization from the view of choosing an ionization method. The range of subjects is from ionization of organic and biomolecules to the study of microorganisms.

Reviews range of ionization methods used in mass spectrometry today Includes tutorials describing the principles and instrumentation applied to each method Considers appropriate methods of ionization for analysis of various substances

Theory and Ion Chemistry concentrates on the fundamental aspects of a set of 13 carefully chosen topics covering the whole field of mass spectrometry. It covers both primary (basic) considerations, as well as advanced topics, the former aimed at newcomers to the field, the latter at the experienced practitioner who may not necessarily be an expert in the particular area. Article references will cover three areas: 1) original or pioneering work in the area 2) seminal contributions to the area, including examples illustrating a given application and 3) useful review articles. This volume is the first in the multi-volume work, providing unparalleled and comprehensive coverage of the full range of topics and techniques Suitable for new graduate students who are interested but not yet versed in the subject of mass spectrometry Techniques, methods and applications of mass spectrometry are described in considerable detail; including limitations, current problems, and areas in which the method does not succeed well

Volume 3 looks at classes of biomolecules including carbohydrates, nucleic acids, and lipids. In addition, special areas of application are included, such as pharmaceuticals, natural products, isotope ratio methods for biomolecules analysis, and clinical applications. The articles are arranged under general headings for continuity and ease of access, although several of these are of interest across the various disciplines. The articles are intended to teach and therefore strive to cover basics and sufficient additional detail to bring the reader up-to-date on a given subject. Some advanced topics are also covered, either in a special section of articles or in additional reading citations. Covers the major classes of biomolecules including carbohydrates, nucleic acids, and lipids Includes special areas of application, such as pharmaceuticals, natural products, isotope ratio methods for biomolecules analysis, and clinical applications Written for students entering the field of mass spectrometry

Volume 5: Elemental and Isotope Ratio Mass Spectrometry focuses on (1) the plethora of mostly atomic ionization techniques that have been coupled to MS for elemental analysis, the measurement of isotope ratios, and even the determination of inorganic compounds and (2) the precise measurement of isotope ratios of organic elements as small gas molecules by isotope ratio mass spectrometry (IRMS).

Reviews the wide range of ionization and isotope methods used in inorganic mass spectrometry today Features tutorials describing the key principles and instrumentation relevant to each method Evaluates practical applications for the analysis of environmental, biological, biomedical, nutritional, geological, nuclear, microelectronic and extra-terrestrial materials Includes more than 3400 references, 100 tables and 500 figures of which more than 200 are in color

Volume 4: Organic and Organometallic Compounds presents a cross section of applications in organic and organometallic chemistry in two parts. Chapters 1 to 6 are devoted to the fundamentals whereas chapters 7 and 8 cover applications to organic and organometallic compounds, either available as pure compounds or present in complex mixtures.

Chapter 1 describes the theory for organic mass spectrometry, building on and complementing material in Volume 1. The themes for Chapter 2 are the structures and properties of gas-phase ions of conventional, distonic, and non-covalent complexes. Chapter 3 covers methodology used in study of gas-phase ions. Chapters 4 and 5 turn to mechanisms of both unimolecular and bimolecular reactions of ions and include topics in stereochemistry and radical chemistry. Chapter 6 contains a number of articles on the formation and reactivity of metal ion complexes and organometallic cations and anions, drawing connections with molecular recognition, catalysis and organic synthesis.

Chapter 7 deals with the structure determination of organic compounds, including chiral compounds and natural products. In chapter 8 are contributions that provide illustrative examples of the determination of organic compounds present at low levels in complex samples that originate from various natural and biological sources. Included is an article on the determination of explosives.

Cross section of the field of Organic and Organometallic MS Covers fundamental Ion Chemistry as well as applications from simple to complicated systems Suitable for new graduate students entering the field