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    1. Naturvetenskap och teknik
    2. Matematik och naturvetenskap
    3. Kemi
    4. Organisk kemi

    Key Heterocycle Cores for Designing Multitargeting Molecules

    AvOm Silakari

    Häftad, Engelska, 2018

    1 573 kr

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    E-bok

    2 237 kr

    Beskrivning

    Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets.

    Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research.



    • Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules
    • Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents
    • Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases

    Produktinformation

    • Utgivningsdatum:2018-06-14
    • Mått:152 x 229 x 23 mm
    • Vikt:700 g
    • Format:Häftad
    • Språk:Engelska
    • Antal sidor:436
    • Förlag:Elsevier Science
    • ISBN:9780081020838

    Utforska kategorier

    • Organisk kemi inom Naturvetenskap och teknik

    Mer om författaren

    Dr. Om Silakari is an assistant professor in the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India. He received his Ph.D. degree from Dr. Hari Singh Gour University, India and has been teaching and researching in this area for over 10 years. His research areas include computer-assisted drug designing (CADD) of new anti-inflammatory, antidiabetic and anticancer targets, and the synthesis of new lead molecules. In addition to supervising multiple M. Pharm. and PhD students, he has authored two books and published over 60 papers in international journals. Dr Silakari is an active reviewer for many international journals, has been awarded funding for several research projects, and regularly delivers talks at both national and international conferences.

    Innehållsförteckning

    • 1. Multitargeting heterocycles – An improved and rational chemical probes for multifactorial diseases2. Benzimidazole: Journey from a single targeting to a multitargeting nucleus3. Acridines: A relatively lesser explored heterocycle for multifactorial diseases4. Flavone: An important scaffold for medicinal chemistry5. Thiazolidine-2,4-dione: a potential weapon for targeting multiple pathological conditions6. Oxindole: A nucleus enriched with multi-targeting potential against complex disorders7. Thiazine: A Versatile Heterocyclic Scaffold for Multifactorial Diseases8. Indole: As multi-target directed ligands in medicinal chemistry9. Triazoles: Multidimensional 5-membered nucleus for designing multitargeting agents 10. Benzoxazolinone: A scaffold with diverse pharmacological significance