Adrian has over 25 years of drug discovery and development experience in senior roles across a diverse range of disease areas in both large pharma and biotech environments and been heavily involved in the identification of multiple clinical candidates across a variety of disease areas. He is a co-inventor of RMC-4630, Revolution Medicines first development candidate selectively targeting SHP2 and RMC-5552, a bi-steric inhibitor which selectively targets mTORC1. Adrian has been instrumental in the design and development of four more recent RAS(ON) development candidates from the Revolution Medicines tri-complex inhibitor platform and is also a co-inventor of RMC-6236 (RAS MULTI inhibitor), RMC-6291(KRASG12C inhibitor), RMC-8839 (KRASG13C inhibitor) and RMC-9805(KRASG12D inhibitor). Adrian has authored over 25 publications in peer-reviewed journals, is a named inventor on over 45 issued and pending small molecule patent applications and has given multiple invited presentations at national and international conferences. Adrian received his Ph.D. in organic chemistry from the University of Sussex, U.K. and has a bachelor’s degree in applied chemistry from the University of Salford, U.K. Adrian is a member of the Royal Society of Chemistry, the SCI, the American Chemical Society and an invited member of the AACR Chemistry in Cancer Research (CICR) Steering Committee. Adrian is also a member of XPose Therapeutics and Curve Therapeutics scientific advisory boards and an honorary Prof. of Drug Discovery at the Sussex University Drug Discovery Center, UK.

• How the Ocean--Atmosphere System Is Driven. Transfer of Properties between Atmosphere and Ocean. Properties of a Fluid at Rest. Equations Satisfied by a Moving Fluid. Adjustment under Gravity in a Nonrotating System. Adjustment under Gravity of a Density-Stratified Fluid. Effect of Rotation. Gravity Waves in a Rotating Fluid. Forced Motion. Effects of Side Boundaries. The Tropics. Mid-Latitudes. Instabilities, Fronts, and the General Circulation. Units and Their SI Equivalents. Useful Values. Properties of Seawater. Properties of Moist Air. A List of Atlases and Data Sources. References. Index.