"Within minutes of receiving my review copy of The Oncogene FactsBook I discovered just how useful it could be... I could have found the information I needed in a matter of seconds. There is no doubt that every lab working on oncogenes or growth control should have a copy of this book for reference." --TRENDS IN BIOCHEMICAL SCIENCESPraise for the First Edition:"The introductory chapters on genes and the processes involved in cancer development are very good for undergraduate teaching." --MOLECULAR MEDICINE TODAY

• The Introductory Chapters:Introduction: Identification of Oncogenes.Oncogene Activation in Humans.Proliferation Control Pathways: Oncoprotein Function.Growth Factor-Related Proteins.SRC. RAS and RAF.Nuclear Oncoproteins.ETS. FOS and JUN. MYB. MYC. REL. ERBA.Tumour Suppressor Genes: RB1. P53.Other Major Tumour Suppressor Genes.APC. BRCA1. NF1. VHL. WT1.Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs).Apoptosis: Tumour Suppressor Genes and Apoptosis.DNA Repair.Angiogenesis and Metastasis: Angiogenesis.Angiogenic Promoters.Angiogenic Inhibitors.Metastasis: Correlations with Gene Expression.Cadherins.The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM).Integrins.CD44.Matrix Metalloproteinases (MMPS).Tissue Inhibitors of Metalloproteinases (TIMPs).Cysteine and Aspartic Proteinases and Heparanase.NME1 and NME2.The Multi-step Nature of Cancer: Cervical Carcinoma.Colorectal Carcinoma.Breast Carcinoma.Prostate Carcinoma.Renal Cell Carcinoma.Lung Carcinoma.Lymphomas.Chronic Myeloid Leukemia.Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies.Tumour Suppressor Gene Therapy.Cytokine Gene Therapy and Tumour Vaccination.Virally Directed Enzyme Prodrug Therapy (VDEPT).Antibody-directed Therapy.Tables:Oncogenes Transduced by Retroviruses.Oncogenes Activated by Retroviral Insertion.Oncogenes at Chromosomal Translocations.Tumour Suppressor Genes Detected in Human Tumours.Functions of Oncoproteins.Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes.The Oncogenes:ABL. AKT1 and AKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1 and ETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1 and FRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC. TAL1. THRA/ErbA-1 and THRA2/ErbA-2. TIAM1. TRK. VAV. WNT1. WNT2 and WNT3. YES1.Tumour Suppressor Genes:APC and MCC. BRCA1 and BRCA2. DCC. DPC4. E2F1. E-cadherin/CDH1. MSH2. MSH3. MSH6/GTBP and MLHL. NF1 and NF2. P53, PTC.The Retinoblastoma Gene (RB1). TGFBR1 and TGFBR2. VHL; WT1.Cyclin-dependent Kinase Inhibitors:INK4A/MTS1/MTS2/CDK41/CDKN2. INK4B/MTS2.INK4C and INK4D. KIP1. KIP2. WAF1.DNA Tumour Viruses:Human Papillomaviruses.Epstein-Barr Virus.Subject Index.

"Within minutes of receiving my review copy of The Oncogene FactsBook I discovered just how useful it could be... I could have found the information I needed in a matter of seconds. There is no doubt that every lab working on oncogenes or growth control should have a copy of this book for reference." --TRENDS IN BIOCHEMICAL SCIENCESPraise for the First Edition:"The introductory chapters on genes and the processes involved in cancer development are very good for undergraduate teaching." --MOLECULAR MEDICINE TODAY

• The Introductory Chapters:Introduction: Identification of Oncogenes.Oncogene Activation in Humans.Proliferation Control Pathways: Oncoprotein Function.Growth Factor-Related Proteins.SRC. RAS and RAF.Nuclear Oncoproteins.ETS. FOS and JUN. MYB. MYC. REL. ERBA.Tumour Suppressor Genes: RB1. P53.Other Major Tumour Suppressor Genes.APC. BRCA1. NF1. VHL. WT1.Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs).Apoptosis: Tumour Suppressor Genes and Apoptosis.DNA Repair.Angiogenesis and Metastasis: Angiogenesis.Angiogenic Promoters.Angiogenic Inhibitors.Metastasis: Correlations with Gene Expression.Cadherins.The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM).Integrins.CD44.Matrix Metalloproteinases (MMPS).Tissue Inhibitors of Metalloproteinases (TIMPs).Cysteine and Aspartic Proteinases and Heparanase.NME1 and NME2.The Multi-step Nature of Cancer: Cervical Carcinoma.Colorectal Carcinoma.Breast Carcinoma.Prostate Carcinoma.Renal Cell Carcinoma.Lung Carcinoma.Lymphomas.Chronic Myeloid Leukemia.Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies.Tumour Suppressor Gene Therapy.Cytokine Gene Therapy and Tumour Vaccination.Virally Directed Enzyme Prodrug Therapy (VDEPT).Antibody-directed Therapy.Tables:Oncogenes Transduced by Retroviruses.Oncogenes Activated by Retroviral Insertion.Oncogenes at Chromosomal Translocations.Tumour Suppressor Genes Detected in Human Tumours.Functions of Oncoproteins.Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes.The Oncogenes:ABL. AKT1 and AKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1 and ETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1 and FRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC. TAL1. THRA/ErbA-1 and THRA2/ErbA-2. TIAM1. TRK. VAV. WNT1. WNT2 and WNT3. YES1.Tumour Suppressor Genes:APC and MCC. BRCA1 and BRCA2. DCC. DPC4. E2F1. E-cadherin/CDH1. MSH2. MSH3. MSH6/GTBP and MLHL. NF1 and NF2. P53, PTC.The Retinoblastoma Gene (RB1). TGFBR1 and TGFBR2. VHL; WT1.Cyclin-dependent Kinase Inhibitors:INK4A/MTS1/MTS2/CDK41/CDKN2. INK4B/MTS2.INK4C and INK4D. KIP1. KIP2. WAF1.DNA Tumour Viruses:Human Papillomaviruses.Epstein-Barr Virus.Subject Index.