Fundamentals of Toxicologic Pathology

Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011. Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

From the first edition:"The editors have succeeded in producing a very readable, basic textbook of current toxicologic pathology...The book provides many high quality, well labeled reproductions of light and electron micrographs...This book will be an excellent resource for graduate students in toxicology, pathology, and environmental health studies. It provides a thorough organ system based overview of current knowledge and fundamental principles of toxicologic pathology, devoid of the detailed treatment of descriptive morphology and mechanisms provided in reference texts." --CHOICE "...a very valuable toxicopathological reference source..." --A.A. Seawright in AUSTRALIAN VETERINARY JOURNAL "...a valuable resource to practicioners, including diagnostic veteriarians. This edition focuses on providing information integrated from both toxicology and pathology dealing with the mechanisms of toxic injury and morphologic expression at subcellular, cellular and tissue levels. ...this is an excellent, eminently readable book to have as a study or reference book, covering the essential basics and providing a good overview for any toxicological pathologist, toxicologist or research scientist with an interest in the pathological changes seen in toxicological studies." -- Catherine Sutcliffe, Covance Laboratories Ltd, UK" --The British Toxicology Society Newsletter, Summer 2010 Issue 36

• 1. Principles of Toxicology 2. Manifestations of Toxic Cell Injury -- Cell Injury/Death and Chemical Carcinogenesis3. Clinical Pathology4. Nomenclature-- Terminology for Morphologic Alterations5. Techniques in Toxicologic Pathology6. Respiratory System7. Skin and Oral Mucosa8. Gastrointestinal Tract9. Liver10. Pancreas11. Kidney and Lower Urinary Tract12. Cardiovascular and Skeletal Muscle Systems13. Bones14. Nervous System15. Immune System16. Hematopoietic System17. Endocrine System18. Male Reproduction19. Female Reproduction20. Developmental Toxicology