Textbook of Nephro-Endocrinology

Dr. Singh has led groundbreaking studies in anemia of kidney disease, including the CHOIR study, which was published in the New England Journal of Medicine, and well as being a member of the steering committees for the TREAT and DRIVE studies. More recently, he has taken on the role of leading the ASCEND Clinical development program - a phase 3 program for the development of a novel propyl hydroxylase inhibitor Daprodustat. The trial is aiming to recruit 7500 patients in over countries. He currently leads the office of Postgraduate Medical Education at the Brigham and Women's Hospital, and in this capacity leads several HMS CME courses. He is the author of over 160 original contributions and review articles, as well as author/editor of 11 books in internal medicine and nephrology. Dr. Singh is a Fellow of the Royal College of Physicians in London, and has an MBA from Boston University. Dr. Gordon H. Williams is an endocrinologist in Boston, Massachusetts and is affiliated with Brigham and Women's Hospital. He received his medical degree from Harvard Medical School and has been in practice for more than 30 years. He has published ~300 papers, is a well-respected and well-known expert, speaker and leader in the field of endocrinology.

"This well-written, relatively concise, and current book will find a home on the shelves of many nephrologists and endocrinologists. Because it is so readable, it should be useful for students, experts, and those in between. I know I will consult my copy on a frequent basis - an unusual event in this era of online material." --N Engl J Med, 2009"All in all, this is a solid book that provides substantial up-todate information on endocrine aspects of the kidney. I will be glad to pull it down from my shelf rather than one of the true heavyweights to which I would previously have gone for this kind of reading." --Kidney International, 2009"Written by multidisciplinary experts from several countries, this book is divided into 2 parts and 7 sections. A very useful volume. Each chapter is richly referenced." --Pediatric Endocrinology Reviews

• Part 1: The Kidney as an Endocrine OrganSection 1: Erythropoietin 1. Erythropoientin: An Historical Overview of Physiology, Molecular Biology And Gene Regulation 2.Erythropoiesis: The Role of Erythropoietin and Iron3.Extra-Hematopoietic Action of Erythropoietin4.Development of Recombinant Erythropoietin and Erythropoietin Analogues5.Erythropoietin Disease States & ResistanceSection 2: Vitamin D, PTH and Novel Regulators of Phosphate6. Vitamin D and the Kidney: Introduction and Historical Perspective7.Vitamin D: Molecular Biology and Gene Regulation8.Molecular Biology of Parathyroid Hormone 9.Endocrine Regulation of Phosphate Homeostasis Section 3: Renin-angiotensin 10.Introduction and Historical Overview11.Molecular Biology of Renin and Regulation of Its Gene12. Physiology and Regulation of the RAAS System13. The Renin Angiotensin Aldosterone System and the Kidney14. The Renin Angiotensin and the Heart 15. The Renin-Angrotensin blockade: Therapeutic Agents Part 2: The Kidney as a Hormonal targetSection 4: Anti-diuretic Hormone 16. Vasopressin in the Kidney: Historical Aspects17. Molecular Biology and Gene Regulation18. Vasopressin Antagonists in Physiology and Disease 19. Diabetes Insipidus and SIADH Section 5: The Atrial Natriuretic Peptides 20. ANP, BNP and CNP Physiology and Pharmacology of the Cardiorenal AxisSection 6: Aldosterone 21.Introduction and Historical Overview22.Aldosterone Receptors and Their Renal Effects: Molecular Biology and Gene Regulation23. Aldosterone and Its Cardiovascular Effects24. Aldosterone RegulationSection 7: Endocrine Disorders in Renal Failure25. Insulin resistance 26. Growth hormone 27. Sexual Dysfunction in Men and Women with Chronic Kidney Disease 28. Thyroid Status in Chronic Renal Failure Patients 29.Metabolic Acidosis of Chronic Kidney Disease 30.Pregnancy and the Kidney