Strategies and Tactics in Organic Synthesis

Professor Michael Harmata graduated from the University of Illinois-Chicago with honors and highest distinction in chemistry.In 1980, he began graduate studies in chemistry at the University of Illinois-Champaign/Urbana where he was awarded a University Teaching Fellowship. He worked with Professor Scott E. Denmark on the invention of the carbanion-accelerated Claisen rearrangement. In his second year of study, he was awarded an Eastman Kodak Research Fellowship.Upon graduation in 1985, he was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A. Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin chromophore.In 1986, Prof. Harmata began his independent career at the University of Missouri-Columbia. He became an Associate Professor in 1992 and a full professor in 1998. In 2000, he was named the Norman Rabjohn Distinguished Professor of Chemistry in recognition of his achievements in research and teaching. In 1998, he received a research fellowship from the Alexander von Humboldt Foundation and stayed for a year at the University of Göttingen where he was affiliated with the groups of Professors Reinhard Brückner and Lutz. F. Tietze. In 2000, he served as chair of the Gordon conference on Organic Reactions and Processes. In 2010, he was named the first Justus Liebig Professor of Chemistry at the Justus Liebig Üniversität in Giessen, Germany. In 2011, he was a JSPS fellow. He has been a visiting professor in Giessen and Strasbourg and has delivered over 180 invited lectures in the United States and Europe. He is a member of the American Chemical Society, Gesellschaft Deutscher Chemiker, International Society of Heterocyclic Chemistry, and the Alexander von Humboldt Association of America.

"This book is a chronicle of synthetic problems and strategies written by leading organic chemists, who give their own personal accounts of the practice of organic synthesis. It is part lab. notes and memoir and should be an interesting read for both organic chemistry students and practitioners alike." --J. AM. CHEM. SOC, Vol. 128, no. 10, 2006

• chapter 1 TOTAL SYNTHESIS OF RK-397TOTAL SYNTHESIS OF RK-397chapter 2 A FORMAL TOTAL SYNTHESIS OF THE MARINEDITERPENOID, DIISOCYANOADOCIANEchapter 3 TOTAL SYNTHESES OF ZOAPATANOLchapter 4 SYNTHESIS OF MOLECULAR TWEEZERS ANDCLIPS BY THE USE OF A MOLECULAR LEGO SET AND THEIR SUPRAMOLECULAR FUNCTIONSchapter 5 APPLICATION OF C-GLYCOSIDES IN THE TOTAL SYNTHESIS OF (-)-GAMBIEROLchapter 6 A BIOMIMETIC APPROACH TO THE OCAGLAMIDES EMPLOYING PHOTOGENERATION OF OXIDOPYRYLIUMSDERIVED FROM 3-HYDROXYFLAVONESchapter 7 SYNTHESIS STUDIES OF DOLABELLANES AND TRANSANNULAR PROCESSES LEADING TO RELATED DITERPENESchapter 8 DIPHENYLOXAZINONES: VERSATILE TEMPLATESFOR THE ASYMMETRIC SYNTHESIS OF ??-AMINO ACIDS, PEPTIDE ISOSTERES, AND NATURAL PRODUCTSchapter 9 RHODIUM-CATALYZED CYCLOISOMERIZATIONREACTIONS OF ALLENES IN DIVERSITY-ORIENTEDSYNTHESISchapter 10 HYDROGEN-BOND-MEDIATED ORGANIC SYNTHESIS IN THE SOLID STATE chapter 11 TOTAL SYNTHESES OF NATURAL PRODUCTSUSING THE COMBINED C??H ACTIVATION/COPE REARRANGEMENT AS THE KEY STEPchapter 12 THE TOTAL SYNTHESIS OF AMPHIBIANALKALOIDS USING THE INTRAMOLECULAR SCHMIDT REACTIONchapter 13 SEDUCED BY A SIREN’S CALL: EXPANDINGAPPLICATIONS FOR AROMATIC COMPOUNDS AND THE SYNTHESIS OF (+)-RISHIRILIDE B