Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

"Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly developing subject." --The Lancet

• 1. Immune regulation by B cells and antibodies: a view towards the clinicKai Hoehlig, Vasiliki Lampropoulou, Toralf Roch, Patricia Neves, Elisabeth Calderon-Gomez, Stephen M. Anderton, Ulrich Steinhoff, Simon Fillatreau2. Cumulative Environmental Changes, Antigen Exposure, and the Increase of AllergyTse Wen Chang and Ariel Y. Pan3. FceR1 signalling *tentative title*J. Rivera 4. TCR triggering mechanism *tentative title*Kai W. Wucherpfennig5. IL-17 *tentative title*Casey Weaver